Photoallergic reaction to cyamemazine.

A 50-year-old man presented with a scaly erythema of the face, upper chest, forearms, and dorsum of the hands. He has been treated with cyamemazine for 6 months. Photopatch tests were performed and the patient was diagnosed with photoallergic reaction to cyamemazine. The drug was discontinued and a course of oral steroids was prescribed. The patient was advised to avoid light exposure. There has been no evidence of recurrence during a six-month follow-up period. Photoallergic reactions are much less frequent than phototoxic disorders. It is well known that several drugs including neuroleptics of the phenothiazine family may produce a skin eruption on light-exposed areas by dose-dependent (phototoxic) or photoallergic mechanisms. It is believed that photopatch testing, which is the clinical investigation of choice for suspected photoallergic reactions, is significantly underused in Europe and probably world-wide

High yielding synthesis of oxazole-4-carboxylates from dehydroamino acid derivatives : application as fluorescent markers for peptides

This work was funded by Foundation for Science and Technology (FCT) and FEDER through CQ-UM, National NMR Network (Bruker 400), research project PTDC/QUI/81238/2006 and PhD grant of G.P. SFRH/BD/38766/2007

Tunga Penetrans: Painful Lesions on the Feet—The First Imported Case from Guinea-Bissau

Tungiasis is an endemic disease in certain poor areas around the world. Imported infestations in travelers are becoming more frequent and can lead to considerable morbidity. We report a case of a 50 year-old-man who returned from a trip to Guinea-Bissau with an infection caused by Tunga penetrans

Tumors of skin appendages – A 10-year review

Introdução: Os tumores dos anexos cutâneos representam um grupo heterogéneo de neoplasias benignas e malignas com diferentes diferenciações morfológicas. Material e Métodos: Foi efectuado o estudo retrospectivo dos tumores dos anexos cutâneos diagnosticados na consulta externa do Serviço de Dermatologia do Centro Hospitalar do Porto, EPE-HSA entre 2000 a 2009. Resultados: Foram diagnosticados 404 tumores dos anexos cutâneos. Apenas 3% dos tumores eram malignos. A maioria apresentou uma diferenciação (62,6 %) folicular. Discussão: A revisão da literatura mostrou uma escassez de dados relativos a estudos retrospectivos dos tumores dos anexos cutâneos. Mais estudos são necessários para uma melhor caracterização epidemiológica destas entidades

Pellagra as the initial presentation of Crohn disease

Pellagra is a nutritional disease caused by the deficiency of niacin. We describe a case of pellagra as the initial presentation of Crohn disease, which has been rarely described in the literature