Monitoring the State of the Operator of the Ergatic System in UAV Control Tasks

An important aspect of the application of unmanned systems is the reliability and safety of controlling these devices. An innovative approach has been proposed to improve the efficiency of the pilot operator and the reliability of the automated control system. It includes the development of an algorithm for determining the pilot’s condition based on heart rate analysis. This algorithm helps to assess the condition of the pilot and his ability to control the drone. Another important element of the proposed approach is the algorithm for selecting the control mode of the automated control system for unmanned aerial vehicles, which takes into account information about the functional state of the pilot operator. This algorithm allows the system to automatically switch between different operating modes depending on the condition of the pilot, ensuring optimal control and minimizing the risks of human error. An integrated approach to improving the reliability of the unmanned aerial vehicle control system allows not only improving the work of the pilot operator, but also ensuring the safer and more efficient operation of automated systems

The Prevalence of High Carcinogenic Risk of HPV Genotypes among HIV-Positive and HIV-Negative MSM from Russia

Objective. Men who have sex with men (MSM) have a high risk of lifelong anal cancer caused by high-risk human papillomavirus (HR HPV) infections. The aim of this study was to investigate the prevalence of anal canal HR HPV infection among men who have sex with men (MSM) with and without HIV infection in Moscow (Russia). We evaluated associations of some HIV coinfections (HSV and CMV) and HPV distribution among MSM with and without HIV infection. Methods. Two groups of HIV-positive (n = 60) and HIV-negative (n = 60) MSM were evaluated in the study. Fourteen high-risk (HR) HPV types, HSV1/2, and CMV were investigated in men anal swabs. Results. HR HPVs were found with nearly the same frequency of 66.7% in both groups: HIV-positive and HIV-negative MSM. HIV-positive status was statistically associated with the presence of several (more than two) HPV types (p=0.044). The most prevalent HR HPV genotypes were HPV18, HPV16, HPV56, and HPV33 for HIV-positive MSM and HPV56, HPV51, HPV66, and HPV16 for HIV-negatives. We found a statistically significant association of five HR HPV types with HIV status of MSM: HPV16 (p=0.028), HPV18 (p=0.00006), HPV58 (p=0.003), HPV33 (p=0.019), and HPV39 (p=0.026). The frequency of HSV1 (1.7%) and HSV2 (10%) infections and CMV (3.3%) infection was evaluated in the group of HIV-positive MSM. The frequency of HSV1 (5%) and HSV2 (6.7%) infections and CMV (0%) infection was evaluated, as well, in the group of HIV-negative MSM. Conclusion. Multiple HPV genotypes were detected significantly more often than single HPV genotype in the group of HIV-positive MSM. According to our data, 25% of HIV-positive MSM have HPV39; this is the only one of the five types of HR HPV (16, 18, 58, 33, and 39) associated with this group of MSM that has not yet been included in the HPV vaccines available on the market

Drag on Cylinders Moving in Superfluid ³He-B as the Dimension Spans the Coherence Length

Vibrating probes when immersed in a fluid can provide powerful tools for characterising the surrounding medium. In superfluid 3He-B, a condensate of Cooper pairs, the dissipation arising from the scattering of quasiparticle excitations from a mechanical oscillator provides the basis of extremely sensitive thermometry and bolometry at sub-millikelvin temperatures. The unique properties of the Andreev reflection process in this condensate also assist by providing a significantly enhanced dissipation. While existing models for such damping on an oscillating cylinder have been verified experimentally, they are valid only for flows with scales much greater than the coherence length of 3He, which is of the order of a hundred nanometres. With our increasing proficiency in fabricating nanosized oscillators, which can be readily used in this superfluid, there is a pressing need for the development of new models that account for the modification of the flow around these smaller oscillators. Here we report preliminary results on measurements of the damping in superfluid 3He-B of a range of cylindrical nanosized oscillators with radii comparable to the coherence length and outline a model for calculating the associated drag

Dynamics of macrophage populations of the liver after subtotal hepatectomy in rats

Abstract Background In many clinical cases of extensive liver resection (e.g. due to malignancy), the residual portion is too small to maintain the body homeostasis. The resulting acute liver failure is associated with the compensatory growth inhibition, which is a typical manifestation of the ‘small for size’ liver syndrome. The study investigates possible causes of the delayed onset of hepatocyte proliferation after subtotal hepatectomy (80% liver resection) in rats. Results The data indicate that the growth inhibition correlates with delayed upregulation of the Tnf gene expression and low content of the corresponding Tnfα protein within the residual hepatic tissue. Considering the involvement of Tnf/Tnfα, the observed growth inhibition may be related to particular properties of liver macrophages – the resident Kupffer cells with CD68+CX1CR3−CD11b− phenotype. Conclusions The delayed onset of hepatocyte proliferation correlates with low levels of Tnfα in the residual hepatic tissue. The observed growth inhibition possibly reflects specific composition of macrophage population of the liver. It is entirely composed of embryonically-derived Kupffer cells, which express the ‘proregeneratory’ M2 macrophage-specific marker CD206 in the course of regeneration