8 research outputs found
Research of influence of geomechanical factors and development of methods of increasing rock outcrop stability of drift excavation
The questions of influence of geomechanical factors on rock outcrop stability in the working zone of excavations at their carrying out moment are examined. Methods, which allow increasing their steadiness, are numerate
Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTICβHF: baseline characteristics and comparison with contemporary clinical trials
Aims:
The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is tested in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure (GALACTICβHF) trial. Here we describe the baseline characteristics of participants in GALACTICβHF and how these compare with other contemporary trials.
Methods and Results:
Adults with established HFrEF, New York Heart Association functional class (NYHA)ββ₯βII, EF β€35%, elevated natriuretic peptides and either current hospitalization for HF or history of hospitalization/ emergency department visit for HF within a year were randomized to either placebo or omecamtiv mecarbil (pharmacokineticβguided dosing: 25, 37.5 or 50βmg bid). 8256 patients [male (79%), nonβwhite (22%), mean age 65βyears] were enrolled with a mean EF 27%, ischemic etiology in 54%, NYHA II 53% and III/IV 47%, and median NTβproBNP 1971βpg/mL. HF therapies at baseline were among the most effectively employed in contemporary HF trials. GALACTICβHF randomized patients representative of recent HF registries and trials with substantial numbers of patients also having characteristics understudied in previous trials including more from North America (n = 1386), enrolled as inpatients (n = 2084), systolic blood pressureβ<β100βmmHg (n = 1127), estimated glomerular filtration rate <β30βmL/min/1.73 m2 (n = 528), and treated with sacubitrilβvalsartan at baseline (n = 1594).
Conclusions:
GALACTICβHF enrolled a wellβtreated, highβrisk population from both inpatient and outpatient settings, which will provide a definitive evaluation of the efficacy and safety of this novel therapy, as well as informing its potential future implementation
Experimental substantiation of the parameters of metal underground leaching
The relevance of the research is caused by the need to expand the scope of technology with underground leaching of metals in blocks, as a condition of satisfying natural growing needs of industry for raw materials. The main aim of the research is to substantiate technical ability and economic feasibility of metal extraction from stockpiles, mainly polymetallic ores, non-conforming to traditional technologies for metal production, but suitable for application of innovative technologies of field development. Research methods: semi-industrial tests in underground mining and laboratory researches in percolators with data processing based on multiple regression and correlation analysis and implementation of algorithms for interpretation of the experimental results, analysis of best achievements according to practice, the patent data and publications. Results. The authors have determined new patterns of technological processes of metal extraction from ores by underground leaching. It is proved that the comprehensive improvement of technological processes of development system with underground leaching allows the new technology to compete with the conventional one, especially in the cases where traditional technologies are limited by the capabilities of today's technologies for processing metal ores. Conclusions. The technology with metal underground leaching from rock ore is not a sufficiently used reserve for increasing metal production, first of all scarce and rare, including off-grade ores. The results of pilot tests of technological processes of underground leaching and theoretical calculations reveal sufficient correlation of practice and theory that indicates the possibility of controlling the course of obtaining metals with the adjustment of technology in the course of its development. Underground leaching of poor and off-balance ores will be developed as stocks in convenient regions of the Earth in the near future satisfying both economic and environmental components of mining humanization
Experimental substantiation of the parameters of metal underground leaching
The relevance of the research is caused by the need to expand the scope of technology with underground leaching of metals in blocks, as a condition of satisfying natural growing needs of industry for raw materials. The main aim of the research is to substantiate technical ability and economic feasibility of metal extraction from stockpiles, mainly polymetallic ores, non-conforming to traditional technologies for metal production, but suitable for application of innovative technologies of field development. Research methods: semi-industrial tests in underground mining and laboratory researches in percolators with data processing based on multiple regression and correlation analysis and implementation of algorithms for interpretation of the experimental results, analysis of best achievements according to practice, the patent data and publications. Results. The authors have determined new patterns of technological processes of metal extraction from ores by underground leaching. It is proved that the comprehensive improvement of technological processes of development system with underground leaching allows the new technology to compete with the conventional one, especially in the cases where traditional technologies are limited by the capabilities of today's technologies for processing metal ores. Conclusions. The technology with metal underground leaching from rock ore is not a sufficiently used reserve for increasing metal production, first of all scarce and rare, including off-grade ores. The results of pilot tests of technological processes of underground leaching and theoretical calculations reveal sufficient correlation of practice and theory that indicates the possibility of controlling the course of obtaining metals with the adjustment of technology in the course of its development. Underground leaching of poor and off-balance ores will be developed as stocks in convenient regions of the Earth in the near future satisfying both economic and environmental components of mining humanization
Experimental substantiation of the parameters of metal underground leaching
ΠΠΊΡΡΠ°Π»ΡΠ½ΠΎΡΡΡ ΡΠ°Π±ΠΎΡΡ ΠΎΠ±ΡΡΠ»ΠΎΠ²Π»Π΅Π½Π° Π½Π΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΠΎΡΡΡΡ ΡΠ°ΡΡΠΈΡΠ΅Π½ΠΈΡ ΠΎΠ±Π»Π°ΡΡΠΈ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΠΈ Ρ ΠΏΠΎΠ΄Π·Π΅ΠΌΠ½ΡΠΌ Π²ΡΡΠ΅Π»Π°ΡΠΈΠ²Π°Π½ΠΈΠ΅ΠΌ ΠΌΠ΅ΡΠ°Π»Π»ΠΎΠ² Π² Π±Π»ΠΎΠΊΠ°Ρ
, ΠΊΠ°ΠΊ ΡΡΠ»ΠΎΠ²ΠΈΡ ΡΠ΄ΠΎΠ²Π»Π΅ΡΠ²ΠΎΡΠ΅Π½ΠΈΡ Π·Π°ΠΊΠΎΠ½ΠΎΠΌΠ΅ΡΠ½ΠΎ Π²ΠΎΠ·ΡΠ°ΡΡΠ°ΡΡΠ΅ΠΉ ΠΏΠΎΡΡΠ΅Π±Π½ΠΎΡΡΠΈ ΠΏΡΠΎΠΌΡΡΠ»Π΅Π½Π½ΠΎΡΡΠΈ Π² ΡΡΡΡΠ΅. Π¦Π΅Π»Ρ ΡΠ°Π±ΠΎΡΡ: ΠΎΠ±ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΈΠ΅ ΡΠ΅Ρ
Π½ΠΈΡΠ΅ΡΠΊΠΎΠΉ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΠΈ ΠΈ ΡΠΊΠΎΠ½ΠΎΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠ΅Π»Π΅ΡΠΎΠΎΠ±ΡΠ°Π·Π½ΠΎΡΡΠΈ ΠΈΠ·Π²Π»Π΅ΡΠ΅Π½ΠΈΡ ΠΌΠ΅ΡΠ°Π»Π»ΠΎΠ² ΠΈΠ· Π·Π°ΠΏΠ°ΡΠΎΠ², ΠΏΡΠ΅ΠΈΠΌΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎ ΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΠ°Π»Π»ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΡΠ΄, Π½Π΅ΠΊΠΎΠ½Π΄ΠΈΡΠΈΠΎΠ½Π½ΡΡ
Π΄Π»Ρ ΡΡΠ°Π΄ΠΈΡΠΈΠΎΠ½Π½ΠΎΠΉ ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΡ ΠΌΠ΅ΡΠ°Π»Π»ΠΎΠ², Π½ΠΎ ΠΏΡΠΈΠ³ΠΎΠ΄Π½ΡΡ
Π΄Π»Ρ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΠΈΠ½Π½ΠΎΠ²Π°ΡΠΈΠΎΠ½Π½ΡΡ
ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΠΉ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΠΈ ΠΌΠ΅ΡΡΠΎΡΠΎΠΆΠ΄Π΅Π½ΠΈΠΉ. ΠΠ΅ΡΠΎΠ΄Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ: ΠΏΠΎΠ»ΡΠΏΡΠΎΠΌΡΡΠ»Π΅Π½Π½ΡΠ΅ ΠΈΡΠΏΡΡΠ°Π½ΠΈΡ Π½Π° ΡΡΠ΄Π½ΠΈΠΊΠ°Ρ
ΠΏΠΎΠ΄Π·Π΅ΠΌΠ½ΠΎΠΉ Π΄ΠΎΠ±ΡΡΠΈ ΠΈ Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΡΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π² ΠΏΠ΅ΡΠΊΠΎΠ»ΡΡΠΎΡΠ°Ρ
Ρ ΠΎΠ±ΡΠ°Π±ΠΎΡΠΊΠΎΠΉ Π΄Π°Π½Π½ΡΡ
Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΠΌΠ½ΠΎΠΆΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠ³ΠΎ ΡΠ΅Π³ΡΠ΅ΡΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ ΠΈ ΠΊΠΎΡΡΠ΅Π»ΡΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ Π°Π½Π°Π»ΠΈΠ·Π° Ρ ΡΠ΅Π°Π»ΠΈΠ·Π°ΡΠΈΠ΅ΠΉ Π°Π»Π³ΠΎΡΠΈΡΠΌΠΎΠ², ΠΈΠ½ΡΠ΅ΡΠΏΡΠ΅ΡΠ°ΡΠΈΡ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ² ΠΎΠΏΡΡΠΎΠ², Π΄ΠΎΡΡΠΈΠΆΠ΅Π½ΠΈΠΉ ΠΏΡΠ°ΠΊΡΠΈΠΊΠΈ, ΠΏΠ°ΡΠ΅Π½ΡΠ½ΡΡ
Π΄Π°Π½Π½ΡΡ
ΠΈ ΠΏΡΠ±Π»ΠΈΠΊΠ°ΡΠΈΠΉ. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. ΠΡΡΠ²Π»Π΅Π½Ρ Π½ΠΎΠ²ΡΠ΅ Π·Π°ΠΊΠΎΠ½ΠΎΠΌΠ΅ΡΠ½ΠΎΡΡΠΈ ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΡΠΎΡΠ΅ΡΡΠΎΠ² ΠΈΠ·Π²Π»Π΅ΡΠ΅Π½ΠΈΡ ΠΌΠ΅ΡΠ°Π»Π»ΠΎΠ² ΠΈΠ· ΡΡΠ΄ ΠΏΠΎΠ΄Π·Π΅ΠΌΠ½ΡΠΌ Π²ΡΡΠ΅Π»Π°ΡΠΈΠ²Π°Π½ΠΈΠ΅ΠΌ. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ½ΠΎΠ΅ ΡΠΎΠ²Π΅ΡΡΠ΅Π½ΡΡΠ²ΠΎΠ²Π°Π½ΠΈΠ΅ ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΡΠΎΡΠ΅ΡΡΠΎΠ² ΡΠΈΡΡΠ΅ΠΌΡ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΠΈ Ρ ΠΏΠΎΠ΄Π·Π΅ΠΌΠ½ΡΠΌ Π²ΡΡΠ΅Π»Π°ΡΠΈΠ²Π°Π½ΠΈΠ΅ΠΌ ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ Π½ΠΎΠ²ΠΎΠΉ ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΊΠΎΠ½ΠΊΡΡΠΈΡΠΎΠ²Π°ΡΡ Ρ ΡΡΠ°Π΄ΠΈΡΠΈΠΎΠ½Π½ΠΎΠΉ ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΠ΅ΠΉ, ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎ Π² ΡΠ΅Ρ
ΡΠ»ΡΡΠ°ΡΡ
, ΠΊΠΎΠ³Π΄Π° ΠΌΠ΅ΡΠΎΠ΄Ρ ΡΡΠ°Π΄ΠΈΡΠΈΠΎΠ½Π½ΠΎΠΉ ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΎΠ³ΡΠ°Π½ΠΈΡΠΈΠ²Π°ΡΡΡΡ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡΠΌΠΈ ΡΠ΅Π³ΠΎΠ΄Π½ΡΡΠ½ΠΈΡ
ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΠΉ ΠΏΠ΅ΡΠ΅ΡΠ°Π±ΠΎΡΠΊΠΈ ΠΌΠ΅ΡΠ°Π»Π»ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΡΠ΄. ΠΡΠ²ΠΎΠ΄Ρ. Π’Π΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΡ Ρ ΠΏΠΎΠ΄Π·Π΅ΠΌΠ½ΡΠΌ Π²ΡΡΠ΅Π»Π°ΡΠΈΠ²Π°Π½ΠΈΠ΅ΠΌ ΠΌΠ΅ΡΠ°Π»Π»ΠΎΠ² ΠΈΠ· ΡΠΊΠ°Π»ΡΠ½ΡΡ
ΡΡΠ΄ ΡΠ²Π»ΡΠ΅ΡΡΡ Π΅ΡΠ΅ Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΠΎ ΠΈΡΠΏΠΎΠ»ΡΠ·ΡΠ΅ΠΌΡΠΌ ΡΠ΅Π·Π΅ΡΠ²ΠΎΠΌ ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΡ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΡΡΠ²Π° ΠΌΠ΅ΡΠ°Π»Π»ΠΎΠ², Π² ΠΏΠ΅ΡΠ²ΡΡ ΠΎΡΠ΅ΡΠ΅Π΄Ρ Π΄Π΅ΡΠΈΡΠΈΡΠ½ΡΡ
ΠΈ ΡΠ΅Π΄ΠΊΠΈΡ
, Π² ΡΠΎΠΌ ΡΠΈΡΠ»Π΅ ΠΈΠ· Π½Π΅ΠΊΠΎΠ½Π΄ΠΈΡΠΈΠΎΠ½Π½ΡΡ
ΡΡΠ΄. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΏΠΎΠ»ΡΠΏΡΠΎΠΌΡΡΠ»Π΅Π½Π½ΡΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΡΠΎΡΠ΅ΡΡΠΎΠ² ΠΏΠΎΠ΄Π·Π΅ΠΌΠ½ΠΎΠ³ΠΎ Π²ΡΡΠ΅Π»Π°ΡΠΈΠ²Π°Π½ΠΈΡ ΠΈ ΡΠ΅ΠΎΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ°ΡΡΠ΅ΡΠΎΠ² ΠΎΠ±Π½Π°ΡΡΠΆΠΈΠ²Π°ΡΡ Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΡΡ ΠΊΠΎΡΡΠ΅Π»ΡΡΠΈΡ ΠΏΡΠ°ΠΊΡΠΈΠΊΠΈ ΠΈ ΡΠ΅ΠΎΡΠΈΠΈ, ΡΡΠΎ ΡΠ²ΠΈΠ΄Π΅ΡΠ΅Π»ΡΡΡΠ²ΡΠ΅Ρ ΠΎ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΠΈ ΡΠΏΡΠ°Π²Π»Π΅Π½ΠΈΡ Ρ
ΠΎΠ΄ΠΎΠΌ ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΡ ΠΌΠ΅ΡΠ°Π»Π»ΠΎΠ² Ρ ΠΊΠΎΡΡΠ΅ΠΊΡΠΈΡΠΎΠ²ΠΊΠΎΠΉ ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΠΈ Π² Ρ
ΠΎΠ΄Π΅ Π΅Π΅ ΠΎΡΠ²ΠΎΠ΅Π½ΠΈΡ. ΠΠΎΠ΄Π·Π΅ΠΌΠ½ΠΎΠ΅ Π²ΡΡΠ΅Π»Π°ΡΠΈΠ²Π°Π½ΠΈΠ΅ Π±Π΅Π΄Π½ΡΡ
ΠΈ Π·Π°Π±Π°Π»Π°Π½ΡΠΎΠ²ΡΡ
ΡΡΠ΄ ΠΏΠΎΠ»ΡΡΠΈΡ ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ ΠΏΠΎ ΠΌΠ΅ΡΠ΅ ΠΈΡΡΠ΅ΡΠΏΠ°Π½ΠΈΡ Π·Π°ΠΏΠ°ΡΠΎΠ² Π² ΡΠ΄ΠΎΠ±Π½ΡΡ
Π΄Π»Ρ ΡΠΊΡΠΏΠ»ΡΠ°ΡΠ°ΡΠΈΠΈ ΡΠ΅Π³ΠΈΠΎΠ½Π°Ρ
ΠΠ΅ΠΌΠ»ΠΈ Π² Π±Π»ΠΈΠΆΠ°ΠΉΡΠ΅ΠΉ ΠΈΡΡΠΎΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Π΅, ΠΊΠ°ΠΊ ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΡ, ΡΠ΄ΠΎΠ²Π»Π΅ΡΠ²ΠΎΡΡΡΡΠ°Ρ ΠΎΠ΄Π½ΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎ ΠΈ ΡΠΊΠΎΠ½ΠΎΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΈ ΡΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠ°ΠΌ Π³ΡΠΌΠ°Π½ΠΈΠ·Π°ΡΠΈΠΈ Π³ΠΎΡΠ½ΠΎΠ³ΠΎ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΡΡΠ²Π°.The relevance of the research is caused by the need to expand the scope of technology with underground leaching of metals in blocks, as a condition of satisfying natural growing needs of industry for raw materials. The main aim of the research is to substantiate technical ability and economic feasibility of metal extraction from stockpiles, mainly polymetallic ores, non-conforming to traditional technologies for metal production, but suitable for application of innovative technologies of field development. Research methods: semi-industrial tests in underground mining and laboratory researches in percolators with data processing based on multiple regression and correlation analysis and implementation of algorithms for interpretation of the experimental results, analysis of best achievements according to practice, the patent data and publications. Results. The authors have determined new patterns of technological processes of metal extraction from ores by underground leaching. It is proved that the comprehensive improvement of technological processes of development system with underground leaching allows the new technology to compete with the conventional one, especially in the cases where traditional technologies are limited by the capabilities of today's technologies for processing metal ores. Conclusions. The technology with metal underground leaching from rock ore is not a sufficiently used reserve for increasing metal production, first of all scarce and rare, including off-grade ores. The results of pilot tests of technological processes of underground leaching and theoretical calculations reveal sufficient correlation of practice and theory that indicates the possibility of controlling the course of obtaining metals with the adjustment of technology in the course of its development. Underground leaching of poor and off-balance ores will be developed as stocks in convenient regions of the Earth in the near future satisfying both economic and environmental components of mining humanization
Cardiac myosin activation with omecamtiv mecarbil in systolic heart failure
BACKGROUND The selective cardiac myosin activator omecamtiv mecarbil has been shown to improve cardiac function in patients with heart failure with a reduced ejection fraction. Its effect on cardiovascular outcomes is unknown. METHODS We randomly assigned 8256 patients (inpatients and outpatients) with symptomatic chronic heart failure and an ejection fraction of 35% or less to receive omecamtiv mecarbil (using pharmacokinetic-guided doses of 25 mg, 37.5 mg, or 50 mg twice daily) or placebo, in addition to standard heart-failure therapy. The primary outcome was a composite of a first heart-failure event (hospitalization or urgent visit for heart failure) or death from cardiovascular causes. RESULTS During a median of 21.8 months, a primary-outcome event occurred in 1523 of 4120 patients (37.0%) in the omecamtiv mecarbil group and in 1607 of 4112 patients (39.1%) in the placebo group (hazard ratio, 0.92; 95% confidence interval [CI], 0.86 to 0.99; P = 0.03). A total of 808 patients (19.6%) and 798 patients (19.4%), respectively, died from cardiovascular causes (hazard ratio, 1.01; 95% CI, 0.92 to 1.11). There was no significant difference between groups in the change from baseline on the Kansas City Cardiomyopathy Questionnaire total symptom score. At week 24, the change from baseline for the median N-terminal pro-B-type natriuretic peptide level was 10% lower in the omecamtiv mecarbil group than in the placebo group; the median cardiac troponin I level was 4 ng per liter higher. The frequency of cardiac ischemic and ventricular arrhythmia events was similar in the two groups. CONCLUSIONS Among patients with heart failure and a reduced ejection, those who received omecamtiv mecarbil had a lower incidence of a composite of a heart-failure event or death from cardiovascular causes than those who received placebo. (Funded by Amgen and others; GALACTIC-HF ClinicalTrials.gov number, NCT02929329; EudraCT number, 2016 -002299-28.)