Adaptive RRI Selection Algorithms for Improved Cooperative Awareness in Decentralized NR-V2X

Decentralized vehicle-to-everything (V2X) networks (i.e., C-V2X Mode-4 and NR-V2X Mode-2) utilize sensing-based semi-persistent scheduling (SPS) where vehicles sense and reserve suitable radio resources for Basic Safety Message (BSM) transmissions at prespecified periodic intervals termed as Resource Reservation Interval (RRI). Vehicles rely on these received periodic BSMs to localize nearby (transmitting) vehicles and infrastructure, referred to as cooperative awareness. Cooperative awareness enables line of sight and non-line of sight localization, extending a vehicle's sensing and perception range. In this work, we first show that under high vehicle density scenarios, existing SPS (with prespecified RRIs) suffer from poor cooperative awareness, quantified as tracking error. Decentralized vehicle-to-everything (V2X) networks (i.e., C-V2X Mode-4 and NR-V2X Mode-2) utilize sensing-based semi-persistent scheduling (SPS) where vehicles sense and reserve suitable radio resources for Basic Safety Message (BSM) transmissions at prespecified periodic intervals termed as Resource Reservation Interval (RRI). Vehicles rely on these received periodic BSMs to localize nearby (transmitting) vehicles and infrastructure, referred to as cooperative awareness. Cooperative awareness enables line of sight and non-line of sight localization, extending a vehicle's sensing and perception range. In this work, we first show that under high vehicle density scenarios, existing SPS (with prespecified RRIs) suffer from poor cooperative awareness, quantified as tracking error

Recovery of Otoacoustic Emission Function in Luetic Endolymphatic Hydrops: A Possible Measure of Improvement in Cochlear Function

Syphilis is a preventable and curable multi-organ disease caused by Treponema pallidum that may also affect the inner ear. First reported in 1887 by Adam Politzer, luetic endolymphatic hydrops (LEH) is a treatable complication of syphilis which causes a potentially reversible sensorineural hearing loss. Symptoms of LEH include fluctuating hearing loss (often low frequency), tinnitus, and vertigo. Though audiometric parameters have been examined in patients with otosyphilis, few studies have examined the use of otoacoustic emissions (OAEs) as a tool to measure improvement in cochlear function. Here we report an improvement in hearing loss, speech discrimination, and OAEs following treatment of LEH

Role of efferent innervation on latency of cochlear potentials: a study with strychnine.

The role of the auditory efferent innervation is a subject of great current interest. Its function has been grossly defined as being inhibitory in nature. Detailed work as to its role and especially the role of the homolateral component of the Olivocochlear Bundle is under speculation and investigation by many workers. [...

Adaptive RRI Selection Algorithms for Improved Cooperative Awareness in Decentralized NR-V2X

Decentralized vehicle-to-everything (V2X) networks (i.e., C-V2X Mode-4 and NR-V2X Mode-2) utilize sensing-based semi-persistent scheduling (SPS) where vehicles sense and reserve suitable radio resources for Basic Safety Message (BSM) transmissions at prespecified periodic intervals termed as Resource Reservation Interval (RRI). Vehicles rely on these received periodic BSMs to localize nearby (transmitting) vehicles and infrastructure, referred to as cooperative awareness. Cooperative awareness enables line of sight and non-line of sight localization, extending a vehicle’s sensing and perception range. In this work, we first show that under high vehicle density scenarios, existing SPS (with prespecified RRIs) suffer from poor cooperative awareness, quantified as tracking error. Tracking error is defined as the difference between a vehicle’s true and estimated location as measured by its neighbors. To address the issues of static RRI SPS and improve cooperative awareness, we propose two novel RRI selection algorithms– namely, Channel-aware RRI (Ch-RRI) selection and Age of Information (AoI)-aware RRI (AoI-RRI) selection. Ch-RRI dynamically selects an RRI based on channel resource availability depending upon the (sparse or dense) vehicle densities, whereas AoI-RRI utilizes a novel information freshness metric, called Age of Information (AoI) to select a suitable RRI. Both adaptive RRI algorithms use SPS for selecting transmission opportunities for timely BSM transmissions at the chosen RRI. System-level simulations demonstrate that both proposed schemes outperform the SPS with fixed RRI in terms of improved cooperative awareness. Furthermore, AoI-RRI SPS outperforms Ch-RRI SPS in high densities, whereas Ch-RRI SPS is slightly better than AoI-RRI SPS in low densities

Trismus: An unusual presentation following road accident

Trismus due to trauma usually follows road accidents leading to massive faciomaxillary injury. In the literature there is no report of a foreign body causing trismus following a road accident, this rare case is an exception. We present a case of isolated presentation of trismus following a road accident. This case report stresses on the thorough evaluation of patients presenting with trismus following a road accident

Perineal burn contractures: An experience in tertiary hospital of a Himalayan state

Perineal burn contracture is a rare burn sequel. We conducted a retrospective analysis of cases with perineal burn contractures managed in a tertiary care centre of a Himalayan state. We found that all cases sustained burn injury from burning firewood and the time of presentation was two to six years after the burn injury. We analyzed our treatment method and have classified these contractures into two types

Perineal burn contractures: An experience in tertiary hospital of a Himalayan State

Perineal burn contracture is a rare burn sequel. We conducted a retrospective analysis of cases with perineal burn contractures managed in a tertiary care centre of a Himalayan state. We found that all cases sustained burn injury from burning firewood and the time of presentation was two to six years after the burn injury. We analyzed our treatment method and have classified these contractures into two types

Extravasational side effects of cytotoxic drugs: A preventable catastrophe

In addition to their therapeutic effects on malignant cells, cytotoxic agents have the potential of causing destruction of healthy, normal cells. Extravasation of the drug can produce extensive necrosis of the skin and subcutaneous tissue. Management of these extravasational effects differs from one centre to another and prevention is usually strongly emphasized. We analyzed our management of 12 patients referred to us over five years with extravasation of cytotoxic drugs and reviewed the literature for different approaches with regard to prophylaxis and management of extravasational effects

First-in-human phase I study of immunomodulatory E7046, an antagonist of PGE2-receptor E-type 4 (EP4), in patients with advanced cancers

Background E7046 is a highly selective, small-molecule antagonist of the E-type prostanoid receptor 4 (EP4) for prostaglandin E2, an immunosuppressive mediator of the tumor immune microenvironment. This first-in-human phase 1 study assessed the safety, tolerability, pharmacokinetics, pharmacodynamics, maximum tolerated dose (MTD) and recommended phase 2 dose of E7046.Methods This first-in-human study enrolled 30 patients with advanced tumors of cancer types associated with high levels of myeloid infiltrates. E7046 was administered orally once-daily in sequential escalating dose cohorts (125, 250, 500, and 750 mg) with ≥6 patients per cohort. Tumor assessments were performed every 6 weeks. Paired tumor biopsies and blood samples, before and on treatment, were collected for pharmacokinetic and pharmacodynamic characterization of the treatment.Results No dose-limiting toxicities were observed, and the MTD was not reached. E7046 had an elimination half-life (t1/2) of 12 hours, and drug exposure increased dose-dependently from 125 to 500 mg. Target modulation by E7046 was supported by changes in genes downstream of EP4 with concurrent enhanced antitumoral immune responses. A best response of stable disease (per irRECIST) was reported in 23% of patients treated with E7046 (n=30) (125 mg: n=2; 250 mg: n=2; 750 mg: n=3). Over half (4/7) of the patients with stable disease had treatment duration of 18 weeks or more, and three patients (3/15; 20%) achieved metabolic responses.Conclusions In this first-in-human study, E7046 administered orally once daily demonstrated manageable tolerability, immunomodulatory effects, and a best response of stable disease (≥18 weeks) in several heavily pretreated patients with advanced malignancies. The 250 and 500 mg doses are proposed for further development in the combination setting.Trial registration number NCT02540291