DEVELOPMENT AND EVALUATION OF OFLOXACIN FLOATING TABLETS USING NATURAL POLYMER: STERCULIA FOETIDA LINN. GUM

Objective: The aim of the present work was to develop a gastro retentive drug delivery system of Ofloxacin with the objective of retarding the drug release when the dosage form is exposed to gastrointestinal fluid.Methods: Floating tablets of Ofloxacin were developed using a natural gum like Sterculia foetida. The prepared tablets were evaluated in terms of their precompression parameters, physical characteristics, in vitro buoyancy, in vitro drug release and release order kinetics. The formulations were optimized for different concentrations of Sterculia foetida.Results: The results of in vitro release studies showed that optimized formulation (F4) could sustain drug release (97.86%) for 24 h and remain buoyant for 24 h. The optimized formulation was subjected to various release kinetic investigations and it was found that the mechanism of drug release was predominantly diffusion with a minor contribution from polymeric relaxation.Conclusion: Floating tablets of Ofloxacin were successfully formulated with the ability of providing controlled release and non-Fickian transport of the drug from tablets was confirmed.Keywords: Ofloxacin, Floating drug delivery system, Sterculia foetida, Buoyanc

Bryophyllum pinnatum leaf extracts prevent formation of renal calculi in lithiatic rats

Background: Bryophyllum pinnatum, commonly known as Pattharcaṭṭa, is used traditionally in ethnomedicinal practices for the treatment of kidney stone and urinary insufficiency. Aim: The present study evaluated the effect of Bryophyllum pinnatum on ethylene glycol (EG)-induced renal calculi in rats. Materials and Methods: Renal calculi were induced in rats by administration of 0.75% EG in drinking water and co-treated orally with standard drug, Cystone (750 mg/kg), or alcoholic and hydro-alcoholic extracts in doses of 100, 200 and 400 mg/kg for 28 days. Weekly body weights were recorded. On day 29, urolithiasis was confirmed by assessing the urinary parameters (urine volume, pH, uric acid, calcium, phosphorus, oxalate, magnesium and creatinine clearance), serum biochemical parameters (creatinine, uric acid, urea, calcium, phosphorus and magnesium), oxidative stress parameters and histology of kidney. Results: Treatment with extracts attenuated the EG-induced decrease in body weight and elevation in urinary parameters (uric acid, calcium, phosphorus and oxalate) and serum biochemical parameters (creatinine, uric acid, urea, calcium, phosphorus and magnesium). Extract treatment also reversed EG-induced decrease in urine volume, pH, magnesium and creatinine clearance, oxidative and histological damages in kidneys. Results were comparable to standard drug, Cystone. Results indicated that EG administration caused renal calculi formation which is prevented by treatment with extracts. The observed antilithiatic effect may be attributed to the presence of high content of phenolics, flavonoids and saponins in the extracts. Conclusion: Bryophyllum pinnatum leaves showed preventive effect against renal calculi formation and validates its ethnomedicinal use in urinary disorders. It further supports its therapeutic potential for the treatment of urinary calculi