Effect of Sertraline on biomarker alterations in patients of multidrug resistant tuberculosis with depression: a prospective clinical trial

Background: Lipid profile parameters may be used as biomarker for depression. Sertraline belongs to selective serotonin reuptake inhibitors (SSRIs), the most commonly used group to treat the depression in multidrug resistant tuberculosis patients.Methods: A prospective clinical trial was carried out in department of Psychiatry and department of Tuberculosis and Respiratory disease G.S.V.M. Medical College, Kanpur. Diagnosed MDR TB patients were screened for depression applying Hamilton Depression Rating Scale (HDRS) and these patients were referred to Psychiatrist for diagnosis of depression. Total 25 diagnosed patients of MDR TB with mild to moderate depression were selected. HDRS Score and morning blood sample of 5ml were collected to analyze biomarker for depression before intervention. Same test was repeated in 18 patients who completed the study at day 30 and 120 after administering Sertraline (50mg). Data were compiled and analyzed using SPSS 20.0 and paired t - test.Results: The mean decrease in HDRS score from base line at day 30 and 120 of administering Sertraline were 6.22 (±1.26) and 2.72 (±0.67) which were significant (p˂0.001). The mean increase in serum cholesterol at day 30 was 153.94 (±19.31) and at day 120 was 157.83 (±19.36) which were significant (p˂0.001). Rest of Tg, HDLc, LDLc and VLDL cholesterole levels were not increased significantly.Conclusions: As the depression symptoms improved by sertraline. The biomarkers of depression were also increased (within the normal range) from baseline but significant increase was observed in serum cholesterol only

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Not AvailableRandomization in run order is a technique commonly employed by the users of response surface designs to avoid biases in the estimates of the effects of interest which might result from a time trend. It is often desirable to execute the observations in an experimental design in such an order that the number of input factor level changes is kept small. Randomizing the run order of a response surface experiment does not always neutralize the effect of undesirable factors. In fact, with some very reasonable assumptions, an important proportion of random orders achieve the same degree of protection as that obtained by experimenting in the standard order. In addition, randomization can induce a large number of changes in factor levels and thus make experimentation expensive and difficult. Here, a methodology to obtain experimentation orders with the desired properties for response surface designs with any number of runs has been discussed.Not Availabl

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Not AvailableResponse surface designs are very commonly used in process and product optimization studies. It is used in situations where several input variables potentially influence some performance measure or quality characteristic of a process. But majority of such studies are based on symmetric rotatable designs. Rotatable designs that are asymmetric are useful in situations where it is desirable to maintain the rotatability but it is difficult or infeasible to have the same number of levels for all the factors. Randomization in run order is a technique commonly employed by the users of response surface designs to avoid biases in the estimates of the effects of interest which might result from a time trend. But, randomization can induce a large number of changes in factor levels and thus make experimentation expensive and difficult. Here, a method to obtain experimentation orders with the desired properties for asymmetric response surface designs has been discussed.Not Availabl

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Not AvailableNeighbour effects from adjacent units are very common in agricultural, clinical, horticultural and agro-forestry experiments. Inference from an experiment may be substantially affected by improper handling of neighbour effects from adjacent experimental units. Hence, for increasing the precision of an experiment where evidence of neighbour effects from adjacent units can be witnessed, it is advisable to incorporate neighbour effects into the model. Here, a block model with directional neighbour effects arising from the adjacent units on either sides has been considered. Further, a class of complete circular block design balanced for directional neighbour effects from the adjacent units up to distance k-1(where k is the block size) on either side has been obtained. The designs so obtained are totally balanced for estimating direct and neighbour effects of treatments.Not Availabl

Not Available

Not AvailableNeighbour effects from adjacent units are very common in agricultural, clinical, horticultural and agro-forestry experiments. Inference from an experiment may be substantially affected by improper handling of neighbour effects from adjacent experimental units. Hence, for increasing the precision of an experiment where evidence of neighbour effects from adjacent units can be witnessed, it is advisable to incorporate neighbour effects into the model. Here, a block model with directional neighbour effects arising from the adjacent units on either sides has been considered. Further, a class of complete circular block design balanced for directional neighbour effects from the adjacent units up to distance k-1(where k is the block size) on either side has been obtained. The designs so obtained are totally balanced for estimating direct and neighbour effects of treatments.Not Availabl

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Not AvailableThis book contains works related to the official language in the Institute, a brief description of the research done by the institute along with various articles and research papers related to agricultural statistics, computer applications in agriculture and agricultural bio-informatrics during the year 2014-15.Not Availabl

Not Available

Not AvailableThis book contains works related to the official language in the Institute, a brief description of the research done by the institute along with various articles and research papers related to agricultural statistics, computer applications in agriculture and agricultural bio-informatrics during the year 2013-14.Not Availabl

Not Available

Not AvailableThis book contains works related to the official language in the Institute, along with brief description of research done by the Institute along with various articles and research papers related to agricultural statistics, computer applications in agriculture and agricultural bio-informatrics during the year 2012-13.Not Availabl

Department of Pharmacology, G.S.V.M. Medical College, Kanpur, Uttar Pradesh, India

Background: Lipid profile parameters may be used as biomarker for depression. Sertraline belongs to selective serotonin reuptake inhibitors (SSRIs), the most commonly used group to treat the depression in multidrug resistant tuberculosis patients.Methods: A prospective clinical trial was carried out in department of Psychiatry and department of Tuberculosis and Respiratory disease G.S.V.M. Medical College, Kanpur. Diagnosed MDR TB patients were screened for depression applying Hamilton Depression Rating Scale (HDRS) and these patients were referred to Psychiatrist for diagnosis of depression. Total 25 diagnosed patients of MDR TB with mild to moderate depression were selected. HDRS Score and morning blood sample of 5ml were collected to analyze biomarker for depression before intervention. Same test was repeated in 18 patients who completed the study at day 30 and 120 after administering Sertraline (50mg). Data were compiled and analyzed using SPSS 20.0 and paired t - test.Results: The mean decrease in HDRS score from base line at day 30 and 120 of administering Sertraline were 6.22 (±1.26) and 2.72 (±0.67) which were significant (p˂0.001). The mean increase in serum cholesterol at day 30 was 153.94 (±19.31) and at day 120 was 157.83 (±19.36) which were significant (p˂0.001). Rest of Tg, HDLc, LDLc and VLDL cholesterole levels were not increased significantly.Conclusions: As the depression symptoms improved by sertraline. The biomarkers of depression were also increased (within the normal range) from baseline but significant increase was observed in serum cholesterol only

Susheel Kumar Sarkar

Not AvailableThis book contains works related to the official language in the Institute, a brief description of the research done by the institute along with various articles and research papers related to agricultural statistics, computer applications in agriculture and agricultural bio-informatrics.Not Availabl