Effects of Unsteady Free Convective MHD Non-Newtonian Flow Through a Porous Medium Bounded by an Infinite Inclined Porous Plate

The problem of unsteady free convective MHD incompressible electrically conducting non-Newtonian fluid through porous medium bounded by on infinite inclined porous plate in the presence of constant suction and absorbing sinks is presented. Uniform magnetic field is applied normal to the plate. The equations governing the fluid flow have been solved using multi-parameter perturbation technique, subject to the relevant boundary conditions. It is noted that the velocity of the fluid and skin friction ore increased as permeability parameter and angle of inclination increases, whereas reverse phenomenon is observed in case of magnetic field strength and sink strength. Velocity and temperature are greater for mercury than that of electrolytic solution. Rate of heat transfer decreases with increase in the sink strength. The results ore discussed through graphs and tables

Cow Urine Mediated Green Synthesis of Nanomaterial and Their Applications: A State-of-the-art Review

Nowadays, green syntheses have received crucial attention as a reliable, developing and eco-benevolent protocol for synthesizing a broad range of nanomaterials (NMs) including metal/metal oxides NMs, bio-inspired materials and hybrid/composite NMs. As such, biogenic synthesis is regarded as a significant tool to mitigate the destructive impacts associated with the conventional approaches of synthesis for NMs generally utilized in industry and laboratory. In this review, we summed up the general protocols and mechanisms of green synthesis routes, especially for silver (Ag), silver oxide (Ag2O), cadmium (Cd), copper (Cu), copper ferrite (CuFe2O4), palladium (Pd), aceprophyline, cellulose and graphene nanomaterials/nanoparticles using cow urine. Importantly, we explored the main role of biological constituents which is existed in cow urine. These essential biomolecules act as reducing/stabilizing agents in solvent systems. The stability, phase formation and surface morphology of NMs using characterization techniques are also discussed. Finally, we covered the eclectic applications of such synthesized NMs in terms of anti-asthma, antimicrobial, antituberculosis, antioxidant, anticancer activity, catalytic activity and removal of pollutants dyes

A review on environmentally benevolent synthesis of CdS nanoparticle and their applications

The word ‘Nano’ received great attention of world, due to their fabulous and novel applications in numerous fields. Cadmium sulphide nanoparticles (CdS NPs) are unique in their properties due the size and shape, and are popular in the area of biosensor, bio-imaging, nano-medicine, molecular pathology, antimicrobial activities, photovoltaic cells, semiconductor, and drug delivery, etc. Due to its fascinating applications, it was synthesized using several methods and explored for its all possible applications. The most affordable, efficient, friendly and biocompatible way of creation of CdS NPs is biogenic synthesis using microorganisms such as bacteria, fungus, algae, enzymes, proteins and parts of plants. In biogenic synthesis of CdS, cadmium undergoes bio-reduction by the variety of natural products present in microorganism as well as in plants. In present review, inclusive study was piloted on the nano-synthesis, characterization and various applications of CdS NPs made using different plant sources and microorganism

Discovery of Pyrimidine- and Coumarin-Linked Hybrid Molecules as Inducers of JNK Phosphorylation through ROS Generation in Breast Cancer Cells

Human epidermal growth factor receptor 2 (HER2)-positive breast cancer exhibits early relapses, poor prognoses, and high recurrence rates. Herein, a JNK-targeting compound has been developed that may be of utility in HER2-positive mammary carcinoma. The design of a pyrimidine-and coumarin-linked structure targeting JNK was explored and the lead structure PC-12 [4-(3-((2-((4-chlorobenzyl)thio) pyrimidin-4-yl)oxy)propoxy)-6-fluoro-2H-chromen-2-one (5d)] was observed to selectively inhibit the proliferation of HER2-positive BC cells. The compound PC-12 exerted DNA damage and induced apoptosis in HER-2 positive BC cells more significantly compared to HER-2 negative BC cells. PC-12 induced PARP cleavage and down-regulated the expression of IAP-1, BCL-2, SURVIVIN, and CYCLIN D1 in BC cells. In silico and theoretical calculations showed that PC-12 could interact with JNK, and in vitro studies demonstrated that it enhanced JNK phosphorylation through ROS generation. Overall, these findings will assist the discovery of new compounds targeting JNK for use in HER2-positive BC cells