Objectively assessed disease activity and drug persistence during ustekinumab treatment in a nationwide real-world Crohn's disease cohort

ObjectiveLong-term evidence on ustekinumab treatment response and persistence in patients with Crohn's disease in a real-world setting is scarce. We performed a retrospective nationwide chart review study of long-term clinical outcomes in Crohn's disease patients treated with ustekinumab.MethodsThe study was conducted in 17 Finnish hospitals and included adult Crohn's disease patients who received an initial intravenous dose of ustekinumab during 2017-2018. Disease activity data were collected at baseline, 16 weeks, and 1 year from health records.ResultsThe study included 155 patients. The disease was stricturing or penetrating in 69 and 59% had prior Crohn's disease-related surgeries, and 97% had a treatment history of at least one biologic agent. Of 93 patients with >= 1 year of follow-up, 77 (83%) were still on ustekinumab at 1 year. In patients with data available, from baseline to the 1-year follow-up the simple endoscopic score for Crohn's disease (SES-CD) decreased from 10 to 3 (P = 0.033), C-reactive protein from 7 to 5 mg/L, (P ConclusionsUstekinumab treatment in patients with highly refractory Crohn's disease resulted in high long-term treatment persistence and significantly reduced disease activity, assessed with objective markers for intestinal inflammatory activity.</div

EU FP7 INFSO-ICT-317669 METIS, D1.1 Scenarios, requirements and KPIs for 5G mobile and wireless system

This deliverable introduces generic scenarios based on fundamental challenges, and the specific problem description of test cases that will be relevant for beyond future radio access. Specific characteristics of each scenario and each test case include the key assumptions regarding requirements and key performance indicators. In order not to constrain the potential solutions, the requirements are specified from an end-user perspective. The deliverable will not only serve as the guideline for the technical work and system concept design in METIS, but also can serve in external research communities to help to harmonize the work towards the future radio access system including the new generation system of 5