Evaluation of screening practices for primary hyperaldosteronism by specialists and general practitioners: an observational, cross-sectional study

ABSTRACT Objective: Despite its recognized importance, primary hyperaldosteronism (PHA) remains an underdiagnosed condition in clinical practice. The objective of the present study was to evaluate PHA screening practices by general practitioners and specialists in endocrinology and cardiology. Subjects and methods: This cross-sectional, observational study invited physicians to respond voluntarily to an online survey. The survey collected the respondents’ sociodemographic data and answers to five hypothetical clinical cases meeting Endocrine Society criteria for PHA screening. Results: In all, 126 physicians responded to the online survey. Endocrinologists were the specialists who most often chose PHA screening, although the screening rates were overall low, ranging from 36.5% to 92.9%, depending on the case and the respondents’ specialty. The survey also assessed the reasons for not choosing PHA screening, which included limited availability of tests within the public health services, interference of antihypertensive medications on hormone levels, and failure to identify the screening indication. Being an endocrinologist was an independent predictor for choosing PHA screening for the patients in Cases #1 and #5 (p = 0.001 and p = 0.002, respectively). Conclusion: Endocrinologists were the specialists who most often chose PHA screening, although the screening rates were overall low among all specialists. These findings highlight a need for continuing medical education programs addressing PHA screening and making the diagnosis of PHA more present in the daily clinical practice of physicians treating patients with hypertension

A DEMANDA POR ALIMENTOS E O BEM-ESTAR DO CONSUMIDOR CAMPO-GRANDENSE

O padrão do consumo de alimentos de um indivíduo é resultado, basicamente, de seu poder aquisitivo. Pessoas com baixo poder aquisitivo tende a mostrar maior sensibilidade à variação de preços, onde uma elevação dos preços dos alimentos pode ocasionar alterações em seus hábitos alimentares. Sendo assim, este trabalho tem por objetivo verificar se alterações na renda dos consumidores e preços dos alimentos afetam os hábitos alimentares dos indivíduos de baixa renda. Nestes termos, para poder retratar bem os gastos das famílias tornam-se imprescindíveis revisões no índice de custo de vida e do bem-estar da população. Para tanto, este trabalho utilizará como ferramenta para o cálculo do índice do custo de vida os índices de Laspeyres, calculado por meio de fatores de ponderação determinados a partir de preços e de quantidades da época básica; índice de Paasche, o qual pondera os preços de insumos em duas épocas, inicial e atual , tomando como pesos às quantidades arbitradas para estes insumos na época atual e; índice de Fischer, que medido pela média geométrica dos índices de Laspeyres e Paasche.----------------------------------------------The pattern of the consumption of an individual's foods is resulted, basically, of his/her purchasing power. People with low purchasing power tend to show larger sensibility to the variation of prices, where an elevation of the prices of the foods can cause alterations in their eating habits. Being like this, this work has for objective to verify alterations in the consumers' income and prices of the foods affect the individuals' of low income eating habits. In these terms, to portray the expenses of the families well they become indispensable revisions in the cost of living index and of the well-being of the population. For so much, work will use as tool for the calculation of the index of the cost of living the indexes of Laspeyres, made calculations through certain consideration factors starting from prices and of amounts of the basic time; index of Paasche, which considers the prices of inputs in two times, initial and current, taking about weights to the amounts arbitrated for these inputs at that time current and; index of Fischer, that measured for the geometric mean of the indexes of Laspeyres and Paasche.: Consumo de alimentos, Bem-estar do consumidor, Índice de custo de vida, Consumption of foods, the consumer's Well-being, cost of living Index, Food Consumption/Nutrition/Food Safety,

Study of the biogas potential generated from residue: peanut shells

O aumento da produção agrícola gera um grande volume de resíduos, podendo levar a preocupações quanto à sua adequada destinação. O município de Herculândia, no oeste do estado de São Paulo, tem como principal atividade econômica a produção e processamento de amendoim. Nesse processo é gerado um grande volume de cascas. Seguindo a tendência da utilização de resíduos para fins energéticos, atendendo ao estabelecido pelos Objetivos de Desenvolvimento Sustentável (ODS), este trabalho teve como objetivo realizar um estudo sobre o potencial de geração de biogás a partir da casca do amendoim. Para tal, foi construído um protótipo de biodigestor de baixo custo que, em um período de 108 dias, produziu biogás e biofertilizante. Os resultados demostraram que houve produção de biogás a partir do resíduo; entretanto, o volume produzido não propiciou economia no custo de energia elétrica, quando comparado à produção de biogás oriunda de dejetos animais. No entanto, o trabalho demonstrou a importância de prover soluções ao descarte de resíduos da casca de amendoim, efetivamente mitigando futuros problemas ambientais e servindo como alternativa geradora de energia sustentável e de baixo custo, principalmente para pequenos produtores.The increase in agricultural production generates a large volume of waste, which may lead to concerns about its proper destination. The main economic activity in Herculândia City, Western region of São Paulo State, Brazil, is the production and processing of peanuts. In this process, a large volume of peanut shells is generated. Following the current movement of using waste for energy purposes, in compliance with what was established by the Sustainable Development Goals (SDGs), this work aimed to carry out a study on the biogas potential generated from peanut shells. To this end, a low-cost biodigester prototype was built, which, over a period of 108 days, produced biogas and biofertilizer. The results showed that there was production of biogas from peanut waste; however, the volume produced did not provide savings in electricity costs when compared to the production of biogas from animal waste. Nevertheless, the work demonstrated the importance of providing solutions to the disposal of peanut shells, effectively mitigating future environmental problems, and serving as an alternative for generating sustainable and low-cost energy, especially for small producers

Differential metabolic and biological profiles of Lychnophora ericoides mart. (Asteraceae) from different localities in the Brazilian "campos rupestres"

This paper reports HPLC-DAD-MS/MS and HPLC-ECD characterisation of secondary metabolite profiles of Lychnophora ericoides Mart. leaf extracts from different provenances and their cytotoxic and antioxidant properties. Leaf extracts from populations representing seven different locations were evaluated for antioxidant activity by the DPPH radical scavenging system and activity towards cellular growth in three tumor cell lines. The extracts were electrochemically analysed by HPLC-ECD and their main secondary metabolites were identified by HPLC-DAD-MS and HPLC-DAD-MS/MS. An amplified defensive secondary chemistry, together with maximal cytotoxic and antioxidant bioactivities, were found for plants collected at the interface between two types of forest. These findings furnish additional support for the hypothesis that plants occurring at the interface between two forests ecosystems might be stimulated to amplify their own production and storage of defensive secondary metabolites due to the greater number of environmental influences

Predictive Demand Service for Public Transit Using CNN/ Atendimento Preditivo de Demanda do Transporte Público Coletivo Usando CNN

Several cities in Brazil undergo a territorial expansion and inhabitants constantly, this process is called urbanization. An uncontrolled urbanization generates many difficulties, highlighting the mobility of public transport, since many citizens depend on this mobility, we have, for example, public transport in Goiânia, which directly affects the living conditions of passengers. For your foreknowledge, a model capable of mirroring the performance of your demand is essential, providing that the system meets users in an acceptable way. A two-dimensional CNN is a CNN model that has a hidden convolutional layer that operates on a 1D sequence, it is a convenient mechanism to simulate a univariate forecast of time series of the predictive service of Goiânia's public transport. The method is equivalent to an analysis of the focal parts that make up the public transport system and how to represent it in the 1D convolutional neural network. Actual data of the systems and their results were compared to those expected, showing the model's effectiveness. This work manifests a forecast of the demand for public transport in Goiânia, to make it susceptible to users of the system.

O Efeito da Idade Relativa em Jovens Atletas de Paraatletismo: Análise do quartil de nascimento e do desempenho em eventos individuais de atletismo

El Efecto de la Edad Relativa (EER) es un fenómeno caracterizado por una sobrerrepresentación significativa de atletas nacidos en los primeros meses del año competitivo en la misma categoría deedad que se ha observado en categorías juveniles de atletismo. Sin embargo, hay una falta de investigación para investigar este fenómeno y su relación con el deporte para, y no está claro si este efectoestá presente en los jóvenes atletas. Por lo tanto, nuestro estudio examinó la existencia de EER en jóvenes atletaspara-atléticos (categorías U16, U18 y U20) y el rendimiento en eventos deportivos individuales según el cuartil denacimiento (Q1, Q2, Q3 yQ4). Las fechas de nacimiento se recogieron de 700 jóvenes atletas masculinos de deportes para que participaran en eventos deportivos individuales entre 2018 y 2019 en las categorías U16, U18 y U20. En resumen, se observó una distribución desigual de las fechas de nacimiento por cuartil cuando un mayor número de jóvenes para-atletas nació en el primer trimestre del año para U16 (χ²3= 18.785; p = .0003; Phi efecto = 0.45), U18 (χ²3= 6.846; p= .05; Phi efecto = 0.17), y U20 (χ²3= 10.156; p = .017; Phiefecto = 0.17). Sin embargo, cuando comparamos el desempeño de los atletas por evento (eventos de atletismo) y por separado por cuartil, no se encontró diferencia significativa (p> .05). En conclusión, nuestro estudio evidenció el papel influyente de laedad relativa en atletismo, pero parece que este fenómeno no está relacionado con el rendimiento en atletismo.The Relative Age Effect (RAE) is a phenomenon characterized by a significant over-representation ofathletes born in the first months of the competitive year in the same age category that has been observed in athletics juvenile categories. However, there is a lack of research to investigate this phenomenon and its relationship with para-sport, and it isnot clear whether this effect is present in young para-athletes. Thus, the present study aims to examine the existence of RAE in young para-athletics athletes (U16, U18, and U20 categories) and the performance in individual athletic events according to the birth quartile (Q1, Q2, Q3, and Q4). Birth dates were collected from 700 young male athletes from para-sport who participated in individual athletic eventsbetween 2018 and 2019 in the U16, U18, and U20 categories. In summary, unequal distribution of birth dates per quartile was observed where a greater number of young para-athletes was born in the Q1 of the year for U16 (χ²3= 18.785; p = .0003; Phi effect = .45), U18 (χ²3= 6.846; p= .05; Phi effect = .17), and U20 (χ²3= 10.156; p= .017; Phi effect =.17). However,when we compared the performance of the athletes by event (track and field events) and separately by quartile, no significant difference was found (p> .05). In conclusion, our study evidenced the influential role of relative age in track and field para-athletes, but it seems that this phenomenon is not related to performance in track and field eventsO Efeito da Idade Relativa (EIR) é um fenômeno caracterizado por uma significativa representação de atletas nascidos nos primeiros meses do ano competitivo na mesma faixa etária que tem sido observada em categorias juvenis de atletismo. No entanto, há ainda uma lacuna em termos de investigaçãopara analisar esse fenômeno e sua relação com o para-desporto. Assim, o obejtivo do presente estudo foi analisar a existência de EIR em atletas jovens de para-atletismo (categorias Sub-16, Sub-18 e Sub-20) e sua relação com o desempenho em eventos atléticos individuais de acordo com o quartil de nascimento (Q1, Q2, Q3 e Q4). As datas de nascimento foram recolhidas de 700 jovens atletas do sexo masculino de paradesporto que participaram de eventos de atletismo individuais entre 2018 e 2019 nas categorias Sub-16, Sub-18 e Sub-20. No geral, observou-se uma distribuição desigual das datas de nascimento por quartil, onde um maior número de jovens para-atletas nasceu no Q1 do ano para Sub-16 (χ²3= 18.785; p = .0003; Phi effect = .45), Sub-18 (χ²3= 6.846; p= .05; Phi effect = .17), e Sub-20 (χ²3= 10.156; p= .017; Phi effect = .17). Entretanto, quando comparamos o desempenho dos atletas por evento (provas de atletismo) e separadamente por quartil, não houve diferenças significativas (p> .05). Em conclusão, nosso estudo evidenciou o papel influente da idade relativa em paraatletas de atletismo, mas parece que esse fenômeno não está relacionadoao desempenho em eventos desta modalidade

O Efeito da Idade Relativa em Jovens Atletas de Paraatletismo: Análise do quartil de nascimento e do desempenho em eventos individuais de atletismo

The Relative Age Effect (RAE) is a phenomenon characterized by a significant over-representation of athletes born in the first months of the competitive year in the same age category that has been observed in athletics juvenile categories. However, there is a lack of research to investigate this phenomenon and its relationship with para-sport, and it is not clear whether this effect is present in young para-athletes. Thus, the present study aims to examine the existence of RAE in young para-athletics athletes (U16, U18, and U20 categories) and the performance in individual athletic events according to the birth quartile (Q1, Q2, Q3, and Q4). Birth dates were collected from 700 young male athletes from para-sport who participated in individual athletic events between 2018 and 2019 in the U16, U18, and U20 categories. In summary, unequal distribution of birth dates per quartile was observed where a greater number of young para-athletes was born in the Q1 of the year for U16 (χ²3 = 18.785; p = .0003; Phi effect = .45), U18 (χ²3 = 6.846; p = .05; Phi effect = .17), and U20 (χ²3 = 10.156; p = .017; Phi effect = .17). However when we compared the performance of the athletes by event (track and field events) and separately by quartile, no significant difference was found (p > .05). In conclusion, our study evidenced the influential role of relative age in track and field para-athletes, but it seems that this phenomenon is not related to performance in track and field events.El Efecto de la Edad Relativa (EER) es un fenómeno caracterizado por una sobrerrepresentación significativa de atletas nacidos en los primeros meses del año competitivo en la misma categoría de edad que se ha observado en categorías juveniles de atletismo. Sin embargo, hay una falta de investigación para investigar este fenómeno y su relación con el deporte para, y no está claro si este efecto está presente en los jóvenes atletas. Por lo tanto, nuestro estudio examinó la existencia de EER en jóvenes atletas para-atléticos (categorías U16, U18 y U20) y el rendimiento en eventos deportivos individuales según el cuartil de nacimiento (Q1, Q2, Q3 y Q4). Las fechas de nacimiento se recogieron de 700 jóvenes atletas masculinos de deportes para que participaran en eventos deportivos individuales entre 2018 y 2019 en las categorías U16, U18 y U20. En resumen, se observó una distribución desigual de las fechas de nacimiento por cuartil cuando un mayor número de jóvenes para-atletas nació en el primer trimestre del año para U16 (χ²3 = 18.785; p = .0003; Phi efecto = 0.45), U18 (χ²3 = 6.846; p = .05; Phi efecto = 0.17), y U20 (χ²3 = 10.156; p = .017; Phi efecto = 0.17). Sin embargo, cuando comparamos el desempeño de los atletas por evento (eventos de atletismo) y por separado por cuartil, no se encontró diferencia significativa (p > 0.05). En conclusión, nuestro estudio evidenció el papel influyente de la edad relativa en atletismo, pero parece que este fenómeno no está relacionado con el rendimiento en atletismo.O Efeito da Idade Relativa (EIR) é um fenômeno caracterizado por uma significativa representação de atletas nascidos nos primeiros meses do ano competitivo na mesma faixa etária que tem sido observada em categorias juvenis de atletismo. No entanto, há ainda uma lacuna em termos de investigação para analisar esse fenômeno e sua relação com o para-desporto. Assim, o obejtivo do presente estudo foi analisar a existência de EIR em atletas jovens de para-atletismo (categorias Sub-16, Sub-18 e Sub-20) e sua relação com o desempenho em eventos atléticos individuais de acordo com o quartil de nascimento (Q1, Q2, Q3 e Q4). As datas de nascimento foram recolhidas de 700 jovens atletas do sexo masculino de paradesporto que participaram de eventos de atletismo individuais entre 2018 e 2019 nas categorias Sub-16, Sub-18 e Sub-20. No geral, observou-se uma distribuição desigual das datas de nascimento por quartil, onde um maior número de jovens para-atletas nasceu no Q1 do ano para Sub-16 (χ²3 = 18.785; p = .0003; Phi effect = .45), Sub-18 (χ²3 = 6.846; p = .05; Phi effect = .17), e Sub-20 (χ²3 = 10.156; p = .017; Phi effect = .17). Entretanto, quando comparamos o desempenho dos atletas por evento (provas de atletismo) e separadamente por quartil, não houve diferenças significativas (p > .05). Em conclusão, nosso estudo evidenciou o papel influente da idade relativa em paraatletas de atletismo, mas parece que esse fenômeno não está relacionado ao desempenho em eventos desta modalidade

Imunofluorescência para diagnóstico de herpes oftálmico usando como modelo córneas de camundongos infectados

Herpes simplex virus type 1 (HSV-1) ophthalmic disease is the most common cause of corneal blindness in humans world-wide. Current culture techniques for HSV take several days and commercially available HSV laboratory based diagnostic techniques vary in sensitivity. Our study was conducted to evaluate the use of a quicker and simpler method to herpes ophthalmic diagnosis. Corneal smears were made by firm imprints of infected mouse eyes to glass slides, after smears were fixated with cold acetone, and an indirect immunofluorescence (IIF) method was performed using monoclonal antibodies in a murine model of ophthalmic herpes. Eye swabs from infected mice were inoculated in Vero cells for virus isolation. Cytology and histology of the eye were also performed, using hematoxylin-eosin routine. Mouse eyes were examined by slit-lamp biomicroscopy for evidence of herpetic disease at various times postinoculation. We made a comparative evaluation of sensitivity, specificity and speed of methods for laboratory detection of HSV. Our results indicate that this IIF method is quick, sensitive, specific and can be useful in the diagnosis of ophthalmic herpes as demonstrated in an animal model.A doença oftálmica do vírus herpes simplex do tipo 1 (HSV-1) é a causa mais comum de cegueira córnea em humanos mundialmente. Técnicas de cultura atuais para HSV levam vários dias e laboratórios de HSV comercialmente disponíveis estabelecem que as técnicas diagnósticas variam em sensibilidade. Nosso estudo foi conduzido para avaliar a aplicação prática de um método mais rápido e simples para diagnosticar o herpes oftálmico. Decalques córneos foram feitos por impressões firmes de olhos de camundongos a lâminas de vidro, depois os decalques foram fixados com acetona fria, e um método de imunofluorescência indireta (IIF) foi executado empregando anticorpos monoclonais no modelo murino de herpes oftálmico. Swabs de córnea foram inoculados em células Vero para o isolamento de vírus a partir de camundongos infectados. A citologia e a histologia do olho foi feita pela rotina de hematoxilina e eosina. Os olhos de camundongos foram examinados através de oftalmomicroscopia para evidência de doença herpética em vários tempos pós-inoculação. A avaliação comparativa da sensibilidade, especificidade e velocidade de métodos para detecção laboratorial de HSV foi feita. Nossos resultados indicam que este método de IIF é rápido, sensível, específico e pode ser útil no diagnóstico de herpes oftálmico como demonstrado no modelo animal

Professional Orientation for Students of Health Courses Study conducted at a Public University in Northern Brazil

This article deals with the results of a research that integrated part of the discipline of Professional Guidance, given in the eighth period of the Psychology course of the Federal University of Rondônia, having as subjects, students of the health courses of a university of western Amazonia. Its objectives include: knowing the type of professional orientation offered in this context, the type of orientation that the students point out as necessary, proposing actions in response to the students\u27 demands. In line with the problem investigated, and in light of the study\u27s main objectives, a descriptive research line was adopted with data collection through interview. Besides being one of the most used in educational research, it presents itself as the most adequate for the proposed objectives. This research has provided a greater theoretical and practical knowledge of the theme orientation and has led to innovative reflections on inciting questions, also opens up new possibilities for research and interest so that further study of this subject can be carried out, not only about the objectives proposed in this work, but also the inferences extracted with a more general character, that can formulate some suggestions of improvement of the analyzed situation