Occurrence of Grammicolepis brachiusculus Poey, 1873 (Pisces: Grammicolepididae) in the Azores Archipelago

Three specimens of Grammicolepis brachiusculus were caught by the commercial bottom hand and longline fisheries off Terceira and Faial Islands, Azores Archipelago. This is the first record of the species for the region, and one of few ever caught in the NE Atlantic

ENERGY COST DURING WALKING AND RUNNING A SAME DISTANCE IS ASSOCIATED WITH VERTICAL OSCILLATION ON GRAVITY CENTER.

The purpose of this study was to evaluate which factors are involved in energetic cost of running and walking a same distance (2,000 meters). Eight healthy men were submitted to walking (5.5km/h) and running (11Km/h) tests, when oxygen consumption, for energy expenditure of exercise, was monitored, and images of volunteers were recorded for vertical oscillation of gravity center. Both, total oxygen consumption and estimated energetic cost were significantly higher during the running test (

Role of estrogen related receptor beta (ESRRB) in DFN35B hearing impairment and dental decay

BACKGROUND: Congenital forms of hearing impairment can be caused by mutations in the estrogen related receptor beta (ESRRB) gene. Our initial linkage studies suggested the ESRRB locus is linked to high caries experience in humans. METHODS: We tested for association between the ESRRB locus and dental caries in 1,731 subjects, if ESRRB was expressed in whole saliva, if ESRRB was associated with the microhardness of the dental enamel, and if ESRRB was expressed during enamel development of mice. RESULTS: Two families with recessive ESRRB mutations and DFNB35 hearing impairment showed more extensive dental destruction by caries. Expression levels of ESRRB in whole saliva samples showed differences depending on sex and dental caries experience. CONCLUSIONS: The common etiology of dental caries and hearing impairment provides a venue to assist in the identification of individuals at risk to either condition and provides options for the development of new caries prevention strategies, if the associated ESRRB genetic variants are correlated with efficacy.Fil: Weber, Megan L.. University of Pittsburgh; Estados UnidosFil: Hsin, Hong Yuan. University of Pittsburgh; Estados UnidosFil: Kalay, Ersan. Karadeniz Technical University; TurquíaFil: Brožková, Dana Š. Charles University; República Checa. University Hospital Motol; República ChecaFil: Shimizu, Takehiko. Nihon University. School of Dentistry; JapónFil: Bayram, Merve. Medipol Istanbul University; TurquíaFil: Deeley, Kathleen. University of Pittsburgh; Estados UnidosFil: Küchler, Erika C.. University of Pittsburgh; Estados UnidosFil: Forella, Jessalyn. University of Pittsburgh; Estados UnidosFil: Ruff, Timothy D.. University of Pittsburgh; Estados UnidosFil: Trombetta, Vanessa M.. University of Pittsburgh; Estados UnidosFil: Sencak, Regina C.. University of Pittsburgh; Estados UnidosFil: Hummel, Michael. University of Pittsburgh; Estados UnidosFil: Briseño Ruiz, Jessica. University of Pittsburgh; Estados UnidosFil: Revu, Shankar K.. University of Pittsburgh; Estados UnidosFil: Granjeiro, José M.. Universidade Federal Fluminense; BrasilFil: Antunes, Leonardo S.. Universidade Federal Fluminense; BrasilFil: Antunes, Livia A.. Universidade Federal Fluminense; BrasilFil: Abreu, Fernanda V.. Universidade Federal Fluminense; BrasilFil: Costabel, Marcelo C.. Universidade Federal do Rio de Janeiro; BrasilFil: Tannure, Patricia N.. Veiga de Almeida University; Brasil. Salgado de Oliveira University; BrasilFil: Koruyucu, Mine. Istanbul University; TurquíaFil: Patir, Asli. Medipol Istanbul University; TurquíaFil: Poletta, Fernando Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas ; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Mereb, Juan C.. Estudio Colaborativo Latino Americano de Malformaciones Congénitas; ArgentinaFil: Castilla, Eduardo Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas ; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Orioli, Iêda M.. Universidade Federal do Rio de Janeiro; BrasilFil: Marazita, Mary L.. University of Pittsburgh; Estados UnidosFil: Ouyang, Hongjiao. University of Pittsburgh; Estados UnidosFil: Jayaraman, Thottala. University of Pittsburgh; Estados UnidosFil: Seymen, Figen. Istanbul University; TurquíaFil: Vieira, Alexandre R.. University of Pittsburgh; Estados Unido

Geoepidemiology of American Cutaneous Leishmaniasis (ACL) in the South of Rondônia, Brazilian Amazon

American Cutaneous Leishmaniasis (ACL) is one of the parasites with specific characteristics in several regions of Brazil. In recent years, there have been variations in the increase in the number of cases of this disease in different regions of the country. In the state of Rondônia, ACL is considered one of the endemic diseases. Objective: This study described epidemiological aspects of ACL in a subspace of Rondônia, Western Amazon, in the period between 2012 and 2013. Method: This is a retrospective epidemiological study developed in 02 municipalities located in the south of Rondônia according to with model developed by Paraguassu-Chaves [3] comprising the municipalities of Vilhena and Chupinguaia. Results: The study revealed that 370 human cases of ACL were reported in the study period. The male gender predominated with (89.5%) of the total cases, the age range (20 to 39) years (36.6%) prevailed, low schooling (80%) had a maximum of complete elementary education (62.5%). The greatest number of cases came from the urban zone (66.9%), resulting from the adaptation of sandflies to the periurbanization of cities in the Amazon, as predicted by Paraguassu-Chaves [3]. Some of these variables presented significant differences when compared to production and distribution in the State of Rondônia. Prevalence of autochthonous cases was 81.7%. Regarding the clinical aspects, the cutaneous lesion (CL) predominated with 90.8% of the new cases. As expected, the cases confirmed by confirmation criteria indicate 89.5% clinical-laboratory confirmation in the studied subspace and 94% in the State of Rondônia. Of the cases confirmed by evolution of the case prevailed to cure with 77.5% and 12.5% ignored or recorded in the blank. The dropout still stands out negatively with 8.4%. Conclusion: The ACL presents a public health problem due to its high endemicity. It was identified some important epidemiological variables for the study in the Brazilian Amazon and that can condition and / or determine areas associated with possible risks of infection by the parasites

Assessing the association between hypoxia during craniofacial development and oral clefts

Objectives: To evaluate the association between hypoxia during embryo development and oral clefts in an animal model, and to evaluate the association between polymorphisms in the HIF-1A gene with oral clefts in human families. Material and Methods: The study with the animal model used zebrafish embryos at 8 hours post-fertilization submitted to 30% and 50% hypoxia for 24 hours. At 5 days post-fertilization, the larvae were fixed. The cartilage structures were stained to evaluate craniofacial phenotypes. The family-based association study included 148 Brazilian nuclear families with oral clefts. The association between the genetic polymorphisms rs2301113 and rs2057482 in HIF-1A with oral clefts was tested. We used real time PCR genotyping approach. ANOVA with Tukey's post-test was used to compare means. The transmission/disequilibrium test was used to analyze the distortion of the inheritance of alleles from parents to their affected offspring. Results: For the hypoxic animal model, the anterior portion of the ethmoid plate presented a gap in the anterior edge, forming a cleft. The hypoxia level was associated with the severity of the phenotype (p<0.0001). For the families, there was no under-transmitted allele among the affected progeny (p>0.05). Conclusion: Hypoxia is involved in the oral cleft etiology, however, polymorphisms in HIF-1A are not associated with oral clefts in humans

Pressure-support ventilation or T-piece spontaneous breathing trials for patients with chronic obstructive pulmonary disease : a randomized controlled trial

Background Little is known about the best strategy for weaning patients with chronic obstructive pulmonary disease (COPD) from mechanical ventilation. Spontaneous breathing trials (SBT) using a T-piece or pressure-support ventilation (PSV) have a central role in this process. Our aim was to compare T-piece and PSV SBTs according to the duration of mechanical ventilation (MV) in patients with COPD. Methods Patients with COPD who had at least 48 hours of invasive MV support were randomized to 30 minutes of T-piece or PSV at 10 cm H2O after being considered able to undergo a SBT. All patients were preemptively connected to non-invasive ventilation after extubation. Tracheostomized patients were excluded. The primary outcome was total invasive MV duration. Time to liberation from MV was assessed as secondary outcome. Results Between 2012 and 2016, 190 patients were randomized to T-piece (99) or PSV (91) groups. Extubation at first SBT was achieved in 78% of patients. The mean total MV duration was 10.82 ± 9.1 days for the T-piece group and 7.31 ± 4.9 days for the PSV group (p < 0.001); however, the pre-SBT duration also differed (7.35 ± 3.9 and 5.84 ± 3.3, respectively; p = 0.002). The time to liberation was 8.36 ± 11.04 days for the T-piece group and 4.06 ± 4.94 for the PSV group (univariate mean ratio = 2.06 [1.29±3.27], p = 0.003) for the subgroup of patients with difficult or prolonged weaning. The study group was independently associated with the time to liberation in this subgroup.Conclusions The SBT technique did not influence MV duration for patients with COPD. For the difficult/ prolonged weaning subgroup, the T-piece may be associated with a longer time to liberation, although this should be clarified by further studies

Análise do Uso de Tecnologias da Informação e Comunicação no Ensino Técnico em Agropecuária

Este artigo descreve os resultados de uma investigação que teve como objetivo realizar um levantamento de tecnologias digitais que pudessem contribuir para o processo de ensino e aprendizagem de disciplinas técnicas da área de agropecuária, dentro da filosofia do software livre. Para o desenvolvimento da pesquisa foram realizadas entrevistas com professores da área técnica, que discutiram as possibilidades pedagógicas das ferramentas que lhes foram apresentadas. Os resultados apontam uma disposição dos docentes para o uso das tecnologias no contexto educacional, porém ainda existe uma grande limitação de recursos disponíveis