Síndrome de burnout, estresse ocupacional e qualidade de vida entre trabalhadores de enfermagem

Objective: To analyze the prevalence of burnout syndrome and its correlation with occupational stress and quality of life among nursing workers. Method: Cross-sectional study addressing 502 nursing professionals from a philanthropic general hospital in the South of Brazil. Data were collected using an instrument addressing sociodemographic, occupational, and lifestyle characteristics, the Maslach Burnout Inventory, the Demand-Control-Support Questionnaire and the World Health Organization Quality of Life – WHOQOL-Bref. Data were analyzed using descriptive and inferential statistics by using Spearman’s rank correlation coefficient. Results: The prevalence of burnout syndrome was 20.9% and its dimensions were related to high demand, low control over work, low social support at work, and negative perceptions of physical, psychological, and social quality of life and of the work environment.Conclusion: Burnout syndrome was related to high levels of stress and a negative perception of quality of life among nursing workers.Objetivo: Analizar la ocurrencia del síndrome de Burnout y su relación con el estrés laboral y la calidad de vida entre trabajadores de enfermería. Método: Se trata de un estudio transversal realizado entre 502 profesionales de enfermería de un hospital general filantrópico de la región sur de Brasil. Los datos se recogieron mediante instrumento con preguntas de caracterización sociodemográfica, ocupacional y de hábitos de vida, el Maslach Burnout Inventory, el Demand-Control-Support Questionnaire y l World Health Organization Quality of Life - Bref.WHOQOL-BREF. Los datos se analizaron por medio de estadística descriptiva e inferencial, en la que se utilizó el coeficiente de correlación de Spearman. Resultados: La ocurrencia del síndrome de burnout fue del 20,9% y sus dimensiones estaban relacionadas con la alta demanda, el bajo control sobre el trabajo, el poco apoyo social recibido en el trabajo, menores percepciones de la calidad de vida física, psicológica, de las relaciones sociales y del medio ambiente. Conclusión: El síndrome de Burnout estaba relacionado con altos niveles de estrés y a la percepción negativa de la calidad de vida de los trabajadores de enfermería.Objetivo: Analisar a ocorrência da síndrome de burnout e sua correlação com o estresse ocupacional e a qualidade de vida entre trabalhadores de enfermagem. Método: Estudo transversal realizado com 502 profissionais de enfermagem de um hospital geral filantrópico da Região Sul do Brasil. Os dados foram coletados por meio de um instrumento com questões de caracterização sociodemográfica, ocupacional e de hábitos de vida, o Maslach Burnout Inventory, o Demand-Control-Support Questionnaire e o World Health Organization Quality of Life - Bref. Os dados foram analisados por estatística descritiva e inferencial, em que utilizou-se o coeficiente de correlação de Spearman. Resultados: A ocorrência de síndrome de burnout foi de 20,9% e suas dimensões relacionaram-se a alta demanda, baixo controle sobre o trabalho, baixo apoio social recebido no trabalho, menores percepções da qualidade de vida física, psicológica, das relações sociais e do meio ambiente. Conclusão: A síndrome de burnout esteve correlacionada aos altos níveis de estresse e à percepção negativa de qualidade de vida dos trabalhadores de enfermagem

Síndrome de Burnout e o trabalho em turnos na equipe de enfermagem

Objetivo: analizar los factores asociados al síndrome de Burnout según el turno de trabajo del equipo de enfermería. Método: estudio transversal desarrollado con una muestra representativa de 502 trabajadores de enfermería, de una institución hospitalaria filantrópica. Los datos fueron recogidos con un instrumento de caracterización, el Maslach Burnout Inventory- Human Service Survey y el Demand-Control-Support Questionnaire. Se analizaron los datos con estadística descriptiva y regresión logística binaria múltiple. Resultados: los niveles del síndrome de Burnout fueron significativamente mayores entre los trabajadores de enfermería del turno diurno. Entre los participantes que trabajaban en el período diurno, los factores asociados a las dimensiones del síndrome de Burnout fueron: alta demanda, bajo control, bajo apoyo social, insatisfacción con el sueño y los recursos financieros, ser enfermero y sedentarismo. En el nocturno fueron bajo apoyo social, insatisfacción con el sueño y el tiempo libre, tener hijos, no tener religión, menor tiempo de trabajo en la institución y ser auxiliar y técnico de enfermería, estos factores aumentaron significativamente las probabilidades de altos niveles del síndrome. Conclusión: los factores psicosociales y del contexto laboral, sobre todo el bajo apoyo social, tuvieron asociación con las dimensiones del síndrome, entre los profesionales de enfermería en los dos turnos.Objetivo: analisar os fatores associados à síndrome de Burnout, segundo o turno de trabalho da equipe de enfermagem. Método: estudo transversal, desenvolvido com uma amostra representativa de 502 trabalhadores de enfermagem de uma instituição hospitalar filantrópica. Os dados foram coletados por meio de um instrumento de caracterização, o Maslach Burnout Inventory-Human Service Survey e o Demand-Control-Support Questionnaire. Analisaram-se os dados por estatística descritiva e regressão logística binária múltipla. Resultados: os níveis da síndrome de Burnout foram significativamente maiores entre os trabalhadores de enfermagem do turno diurno. Entre os participantes que trabalhavam no período diurno, os fatores associados às dimensões da síndrome de Burnout foram: alta demanda, baixo controle, baixo apoio social, insatisfação com o sono e recursos financeiros, ser enfermeiro e, ainda, sedentarismo. Já no noturno, baixo apoio social, insatisfação com o sono e lazer, ter filhos, não ter religião, menor tempo de trabalho na instituição e ser auxiliar e técnico de enfermagem aumentaram significativamente as chances de altos níveis da síndrome. Conclusão: os fatores psicossociais e do contexto laboral, sobretudo o baixo apoio social, tiveram associação com as dimensões da síndrome entre os profissionais de enfermagem de ambos os turnos.Objective: to analyze the factors associated with Burnout Syndrome among nursing workers according to work shift. Method: cross-sectional study addressing a representative sample of 502 nursing workers from a philanthropic hospital facility. Data were collected using a characterization instrument, the Maslach Burnout Inventory – Human Service Survey and the Demand-ControlSupport Questionnaire. Data were analyzed using descriptive statistics and multiple binary logistic regression. Results: levels of Burnout Syndrome were significantly higher among those working the day shift and associated factors included: high demand; low control; low social support; dissatisfaction with sleep and financial resources; being a nurse; and sedentariness. Professionals working the night shift, having low social support, being dissatisfied with sleep, having children, not having a religion, having worked for a short period in the institution, and being a nursing technician or aid were significantly more likely to experience high levels of the syndrome. Conclusion: psychosocial factors and factors from the work context, mainly low social support, were associated with the syndrome dimensions among nursing workers of both shifts

A way to evaluate the peculiarities of drug information centers in university hospitals

The aim of this work was to identify the characteristics of the drug information provided by the Drug Information Center (DIC) of a university hospital. A cross-sectional study was conducted, identifying the profile of information requests (IRs) from January 2008 to December 2009, before and after restructuring. Several parameters were evaluated. The results revealed that this DIC showed a mean of 5.5 IR/month in 2008 and 20.3 in 2009. The majority of IRs came from medical residents (22.7 %) in 2008 and from pharmacists (32.5 %) in 2009. The most recurrent types of IRs were administration route/mode (16.8 %) in 2008 and drug stability (13.1 %) in 2009. The results revealed the importance of the DIC in the hospital, and the restructuring experience could be of help to other DICs in Brazil.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTIC‐HF: baseline characteristics and comparison with contemporary clinical trials

Aims: The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is tested in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure (GALACTIC‐HF) trial. Here we describe the baseline characteristics of participants in GALACTIC‐HF and how these compare with other contemporary trials. Methods and Results: Adults with established HFrEF, New York Heart Association functional class (NYHA) ≥ II, EF ≤35%, elevated natriuretic peptides and either current hospitalization for HF or history of hospitalization/ emergency department visit for HF within a year were randomized to either placebo or omecamtiv mecarbil (pharmacokinetic‐guided dosing: 25, 37.5 or 50 mg bid). 8256 patients [male (79%), non‐white (22%), mean age 65 years] were enrolled with a mean EF 27%, ischemic etiology in 54%, NYHA II 53% and III/IV 47%, and median NT‐proBNP 1971 pg/mL. HF therapies at baseline were among the most effectively employed in contemporary HF trials. GALACTIC‐HF randomized patients representative of recent HF registries and trials with substantial numbers of patients also having characteristics understudied in previous trials including more from North America (n = 1386), enrolled as inpatients (n = 2084), systolic blood pressure < 100 mmHg (n = 1127), estimated glomerular filtration rate < 30 mL/min/1.73 m2 (n = 528), and treated with sacubitril‐valsartan at baseline (n = 1594). Conclusions: GALACTIC‐HF enrolled a well‐treated, high‐risk population from both inpatient and outpatient settings, which will provide a definitive evaluation of the efficacy and safety of this novel therapy, as well as informing its potential future implementation

Burnout Syndrome and shift work among the nursing staff

ABSTRACT Objective: to analyze the factors associated with Burnout Syndrome among nursing workers according to work shift. Method: cross-sectional study addressing a representative sample of 502 nursing workers from a philanthropic hospital facility. Data were collected using a characterization instrument, the Maslach Burnout Inventory - Human Service Survey and the Demand-Control-Support Questionnaire. Data were analyzed using descriptive statistics and multiple binary logistic regression. Results: levels of Burnout Syndrome were significantly higher among those working the day shift and associated factors included: high demand; low control; low social support; dissatisfaction with sleep and financial resources; being a nurse; and sedentariness. Professionals working the night shift, having low social support, being dissatisfied with sleep, having children, not having a religion, having worked for a short period in the institution, and being a nursing technician or aid were significantly more likely to experience high levels of the syndrome. Conclusion: psychosocial factors and factors from the work context, mainly low social support, were associated with the syndrome dimensions among nursing workers of both shifts

Qualitative determination of indole alkaloids of Tabernaemontana fuchsiaefolia (Apocynaceae)

This paper describes a fast and efficient procedure to separate and identify indole alkaloids from the ethanolic extract of Tabernaemontana fuchsiaefolia (Apocynaceae). The alkaloidal fractions obtained from ethanolic extracts of leaves and stem barks and root barks were fractioned and analyzed by Thin-Layer Chromatography (TLC) and by Gas Chromatography coupled to Mass Spectrometry (GC-MS). The following indole alkaloids were identified: ibogamine, coronaridine, ibogaine pseudoindoxyl, voacangine hydroxyindolenine, voacangine pseudoindoxyl, tabernanthine, catharanthine, voacangine, 19-oxovoacangine, 10-hydroxycoronaridine, affinisine, 16-epi-affinine, voachalotine, ibogaline, and conopharyngine

Burnout syndrome, occupational stress and quality of life among nursing workers

Objetivo: Analizar la ocurrenciadel síndrome de Burnout y su relación con el estrés laboral y la calidad de vida entre trabajadores de enfermería. Método: Se trata de un estudio transversal realizado entre 502 profesionales de enfermería de un hospital general filantrópico de la regiónsur de Brasil. Los datos se recogieron mediante instrumento con preguntasde caracterización sociodemográfica, ocupacional y de hábitos de vida,el Maslach Burnout Inventory, el Demand-Control-Support Questionnaire y l World Health Organization Quality ofLife -Bref.WHOQOL-BREF. Los datos se analizaron por medio de estadística descriptiva e inferencial, en la que se utilizó el coeficiente de correlación de Spearman. Resultados: La ocurrenciadel síndrome de burnout fue del 20,9% y sus dimensiones estaban relacionadas con la alta demanda, el bajo control sobre el trabajo, el poco apoyo social recibido en el trabajo, menores percepciones de la calidad de vida física, psicológica, de las relaciones sociales y del medio ambiente. Conclusión: El síndrome de Burnout estaba relacionado conaltos niveles de estrés y a la percepción negativa de la calidad de vida de los trabajadores de enfermería.RESUMO:Objetivo: Analisara ocorrência da síndrome de burnoute sua correlação com o estresse ocupacional e a qualidade de vida entre trabalhadoresdeenfermagem.Método: Estudotransversal realizado com 502 profissionais de enfermagem de um hospital geral filantrópico da Região Sul do Brasil.Os dados foram coletados por meio de um instrumento com questões de caracterização sociodemográfica, ocupacional e de hábitos de vida, o Maslach Burnout Inventory, o Demand-Control-Support Questionnaire e o World Health Organization Quality of Life -Bref. Os dados foram analisados por estatística descritiva e inferencial, em que utilizou-se o coeficiente de correlação de Spearman. Resultados: Aocorrência de síndrome de burnoutfoi de 20,9% e suas dimensões relacionaram-se a alta demanda, baixo controle sobre o trabalho, baixo apoio social recebido no trabalho, menores percepções da qualidade de vida física, psicológica, das relações sociais e do meio ambiente. Conclusão: Asíndrome de burnout esteve correlacionada aos altos níveis de estresse e à percepção negativa de qualidade de vida dos trabalhadores de enfermagem.ABSTRACT:Objective: To analyze the prevalence of burnout syndrome and its correlation with occupational stress and quality of life among nursing workers.Method: Cross-sectional study addressing 502 nursing professionals from a philanthropic general hospital in the South of Brazil.Data were collected using an instrument addressing sociodemographic, occupational, and lifestyle characteristics, the Maslach Burnout Inventory, the Demand-Control-Support Questionnaire and the World Health Organization Quality of Life –WHOQOL-Bref. Data were analyzed using descriptive and inferential statistics by using Spearman’s rank correlation coefficient. Results: The prevalence of burnout syndrome was 20.9% and itsdimensions wererelated to high demand, low control over work, low social support at work, and negativeperceptions of physical, psychological, and social quality of life and of the work environment.Conclusion: Burnout syndrome was related tohigh levels of stress andanegative perception of quality of life among nursing workers

Cardiac autonomic responses during upper versus lower limb resistance exercise in healthy elderly men

Objective: To investigate the cardiac autonomic responses during upper versus lower limb discontinuous resistance exercise (RE) at different loads in healthy older men. Method: Ten volunteers (65±1.2 years) underwent the one-repetition maximum (1RM) test to determine the maximum load for the bench press and the leg press. Discontinuous RE was initiated at a load of 10%1RM with subsequent increases of 10% until 30%1RM, followed by increases of 5%1RM until exhaustion. Heart rate (HR) and R-R interval were recorded at rest and for 4 minutes at each load applied. Heart rate variability (HRV) was analyzed in 5-min segments at rest and at each load in the most stable 2-min signal. Results: Parasympathetic indices decreased significantly in both exercises from 30%1RM compared to rest (rMSSD: 20±2 to 11±3 and 29±5 to 12±2 ms; SD1: 15±2 to 8±1 and 23±4 to 7±1 ms, for upper and lower limb exercise respectively) and HR increased (69±4 to 90±4 bpm for upper and 66±2 to 89±1 bpm for lower). RMSM increased for upper limb exercise, but decreased for lower limb exercise (28±3 to 45±9 and 34±5 to 14±3 ms, respectively). In the frequency domain, the sympathetic (LF) and sympathovagal balance (LF/HF) indices were higher and the parasympathetic index (HF) was lower for upper limb exercise than for lower limb exercise from 35% of 1RM. Conclusions: Cardiac autonomic change occurred from 30% of 1RM regardless of RE limb. However, there was more pronounced sympathetic increase and vagal decrease for upper limb exercise than for lower limb exercise. These results provide a basis for more effective prescription of RE to promote health in this population

SPIRIT checklist.

Atherosclerotic Cardiovascular Disease (ASCVD) represents the leading cause of death worldwide, and individual screening should be based on behavioral, metabolic, and genetic profile derived from data collected in large population-based studies. Due to the polygenic nature of ASCVD, we aimed to assess the association of genomics with ASCVD risk and its impact on the occurrence of acute myocardial infarction, stroke, or peripheral artery thrombotic-ischemic events at population level. CardioVascular Genes (CV-GENES) is a nationwide, multicenter, 1:1 case-control study of 3,734 patients in Brazil. Inclusion criterion for cases is the first occurrence of one of the ASCVD events. Individuals without known ASCVD will be eligible as controls. A core lab will perform the genetic analyses through low-pass whole genome sequencing and whole exome sequencing. In order to estimate the independent association between genetic polymorphisms and ASCVD, a polygenic risk score (PRS) will be built through a hybrid approach including effect size of each Single Nucleotide Polymorphism (SNP), number of effect alleles observed, sample ploidy, total number of SNPs included in the PRS, and number of non-missing SNPs in the sample. In addition, the presence of pathogenic or likely pathogenic variants will be screened in 8 genes (ABCG5, ABCG8, APOB, APOE, LDLR, LDLRAP1, LIPA, PCSK9) associated with atherosclerosis. Multiple logistic regression will be applied to estimate adjusted odds ratios (OR) and 95% confidence intervals (CI), and population attributable risks will be calculated.Clinical trial registration: This study is registered in clinicaltrials.gov (NCT05515653).</div