Thermalization and Cooling of Plasmon-Exciton Polaritons: Towards Quantum Condensation

We present indications of thermalization and cooling of quasi-particles, a precursor for quantum condensation, in a plasmonic nanoparticle array. We investigate a periodic array of metallic nanorods covered by a polymer layer doped with an organic dye at room temperature. Surface lattice resonances of the array---hybridized plasmonic/photonic modes---couple strongly to excitons in the dye, and bosonic quasi-particles which we call plasmon-exciton-polaritons (PEPs) are formed. By increasing the PEP density through optical pumping, we observe thermalization and cooling of the strongly coupled PEP band in the light emission dispersion diagram. For increased pumping, we observe saturation of the strong coupling and emission in a new weakly coupled band, which again shows signatures of thermalization and cooling.Comment: 8 pages, 5 figures including supplemental material. The newest version includes new measurements and corrections to the interpretation of the result

Sense and sensitivity of double beta decay experiments

The search for neutrinoless double beta decay is a very active field in which the number of proposals for next-generation experiments has proliferated. In this paper we attempt to address both the sense and the sensitivity of such proposals. Sensitivity comes first, by means of proposing a simple and unambiguous statistical recipe to derive the sensitivity to a putative Majorana neutrino mass, m_bb. In order to make sense of how the different experimental approaches compare, we apply this recipe to a selection of proposals, comparing the resulting sensitivities. We also propose a "physics-motivated range" (PMR) of the nuclear matrix elements as a unifying criterium between the different nuclear models. The expected performance of the proposals is parametrized in terms of only four numbers: energy resolution, background rate (per unit time, isotope mass and energy), detection efficiency, and bb isotope mass. For each proposal, both a reference and an optimistic scenario for the experimental performance are studied. In the reference scenario we find that all the proposals will be able to partially explore the degenerate spectrum, without fully covering it, although four of them (KamLAND-Zen, CUORE, NEXT and EXO) will approach the 50 meV boundary. In the optimistic scenario, we find that CUORE and the xenon-based proposals (KamLAND-Zen, EXO and NEXT) will explore a significant fraction of the inverse hierarchy, with NEXT covering it almost fully. For the long term future, we argue that Xe-based experiments may provide the best case for a 1-ton scale experiment, given the potentially very low backgrounds achievable and the expected scalability to large isotope masses.Comment: 30 pages, 12 figures, 6 table

Strong coupling between weakly guided semiconductor nanowire modes and an organic dye

The light-matter coupling between electromagnetic modes guided by a semiconductor nanowire and excitonic states of molecules localized in its surrounding media is studied from both classical and quantum perspectives, with the aim of describing the strong-coupling regime. Weakly guided modes (bare photonic modes) are found through a classical analysis, identifying those lowest-order modes presenting large electromagnetic fields spreading outside the nanowire while preserving their robust guided behavior. Experimental fits of the dielectric permittivity of an organic dye that exhibits excitonic states are used for realistic scenarios. A quantum model properly confirms through an avoided mode crossing that the strong-coupling regime can be achieved for this configuration, leading to Rabi splitting values above 100 meV. In addition, it is shown that the coupling strength depends on the fraction of energy spread outside the nanowire, rather than on the mode field localization. These results open up a new avenue towards strong-coupling phenomenology involving propagating modes in nonabsorbing media

Evidence of internal rotation and a helical magnetic field in the jet of the quasar NRAO 150

The source NRAO 150 is a very prominent millimeter to radio emitting quasar at redshift z = 1.52 for which previous millimeter VLBI observations revealed a fast counterclockwise rotation of the innermost regions of the jet. Here we present new polarimetric multi-epoch VLBI-imaging observations of NRAO 150 performed at 8, 15, 22, 43, and 86 GHz with the Very Long Baseline Array (VLBA), and the Global Millimeter VLBI Array (GMVA) between 2006 and 2010. All new and previous observational evidence - i.e., spectral index maps, multi-epoch image cross-correlation, and low level of linear polarization degree in optically thin regions - are consistent with an interpretation of the source behavior where the jet is seen at an extremely small angle to the line of sight, and the high frequency emitting regions in NRAO 150 rotate at high speeds on the plane of the sky with respect to a reference point that does not need to be related to any particularly prominent jet feature. The observed polarization angle distribution at 22, 43, and 86 GHz during observing epochs with high polarization degree suggests that we have detected the toroidal component of the magnetic field threading the innermost jet plasma regions. This is also consistent with the lower degree of polarization detected at progressively poorer angular resolutions, where the integrated polarization intensity produced by the toroidal field is explained by polarization cancellation inside the observing beam. All this evidence is fully consistent with a kinematic scenario where the main kinematic and polarization properties of the 43 GHz emitting structure of NRAO 150 are explained by the internal rotation of such emission regions around the jet axis when the jet is seen almost face on. A simplified model developed to fit helical trajectories to the observed kinematics of the 43GHz features fully supports this hypothesis. This explains the kinematics of the innermost regions of the jet in NRAO 150 in terms of internal jet rotation

Cyclin-Dependent Kinase Inhibitor p21 Controls Adult Neural Stem Cell Expansion by Regulating Sox2 Gene Expression

In the adult brain, continual neurogenesis of olfactory neurons is sustained by the existence of neural stem cells (NSCs) in the subependymal niche. Elimination of the cyclin-dependent kinase inhibitor 1A (p21) leads to premature exhaustion of the subependymal NSC pool, suggesting a relationship between cell cycle control and long-term self-renewal, but the molecular mechanisms underlying NSC maintenance by p21 remain unexplored. Here we identify a function of p21 in the direct regulation of the expression of pluripotency factor Sox2, a key regulator of the specification and maintenance of neural progenitors. We observe that p21 directly binds a Sox2 enhancer and negatively regulates Sox2 expression in NSCs. Augmented levels of Sox2 in p21 null cells induce replicative stress and a DNA damage response that leads to cell growth arrest mediated by increased levels of p19(Arf) and p53. Our results show a regulation of NSC expansion driven by a p21/Sox2/p53 axis

Carbon Monoxide in the Cold Debris of Supernova 1987A

We report spectroscopic and imaging observations of rotational transitions of cold CO and SiO in the ejecta of SN1987A, the first such emission detected in a supernova remnant. In addition to line luminosities for the CO J=1-0, 2-1, 6-5, and 7-6 transitions, we present upper limits for all other transitions up to J=13-12, collectively measured from the Atacama Large Millimeter Array (ALMA), the Atacama Pathfinder EXperiment (APEX), and the Herschel Spectral and Photometric Imaging REceiver (SPIRE). Simple models show the lines are emitted from at least 0.01 solar masses of CO at a temperature > 14 K, confined within at most 35% of a spherical volume expanding at ~ 2000 km/s. Moreover, we locate the emission within 1'' of the central debris. These observations, along with a partial observation of SiO, confirm the presence of cold molecular gas within supernova remnants and provide insight into the physical conditions and chemical processes in the ejecta. Furthermore, we demonstrate the powerful new window into supernova ejecta offered by submillimeter observations.Comment: Accepted to the Astrophysical Journal Letters, 6 pages, 3 figure

DNMT3A mutations mediate the epigenetic reactivation of the leukemogenic factor MEIS1 in acute myeloid leukemia

Close to half of de novo acute myeloid leukemia (AML) cases do not exhibit any cytogenetic aberrations. In this regard, distortion of the DNA methylation setting and the presence of mutations in epigenetic modifier genes can also be molecular drivers of the disease. In recent years, somatic missense mutations of the DNA methyltransferase 3A (DNMT3A) have been reported in ~20% of AML patients; however, no obvious critical downstream gene has been identified that could explain the role of DNMT3A in the natural history of AML. Herein, using whole-genome bisulfite sequencing and DNA methylation microarrays, we have identified a key gene undergoing promoter hypomethylation-associated transcriptional reactivation in DNMT3 mutant patients, the leukemogenic HOX cofactor MEIS1. Our results indicate that, in the absence of mixed lineage leukemia fusions, an alternative pathway for engaging an oncogenic MEIS1-dependent transcriptional program can be mediated by DNMT3A mutations

Radial Velocity Studies of Close Binary Stars. XV

Radial-velocity measurements and sine-curve fits to the orbital radial velocity variations are presented for the last eight close binary systems analyzed the same way as in the previous papers of this series: QX And, DY Cet, MR Del, HI Dra, DD Mon, V868 Mon, ER Ori, and Y Sex. For another seven systems (TT Cet, AA Cet, CW Lyn, V563 Lyr, CW Sge, LV Vir and MW Vir) phase coverage is insufficient to provide reliable orbits but radial velocities of individual components were measured. Observations of a few complicated systems observed throughout the DDO close-binary program are also presented; among them an especially interesting is the multiple system V857 Her which - in addition to the contact binary - very probably contains one or more sub-dwarf components of much earlier spectral type. All suspected binaries which were found to be most probably pulsating stars are briefly discussed in terms of mean radial velocities and projected rotation velocities (v sin i) as well as spectral type estimates. In two of them, CU CVn and V752 Mon, the broadening functions show a clear presence of non-radial pulsations. The previously missing spectral types for the DDO I paper are given here in addition to such estimates for most of the program stars of this paper.Comment: submitted to A