3 research outputs found
Carbon nanotube/dendrimer hybrids as electrodes for supercapacitors.
Carbon nanotubes (CNTs) were surface-modified
by a glycodendrimer with four glucose units (4-Gl).
Electrodes for supercapacitors based on CNT/4-Gl hybrids
were used for the first time in this work. The preparation
was conducted by casting eight alternating bilayers of two
types of modified multiwalled carbon nanotubes
(MWCNTs), MWCNT-COOH/4-Gl and MWCNT-NH2/4-
Gl, from aqueous dispersions (pH= 6). The electrodes showed
good cohesion, dimensional stability, and a homogeneous
nanoscale structure because the carbon nanotube/dendrimer
layers interact electrostatically. The supercapacitor was
stacked with a separator embedded with a 1-ethyl-3-
methylimidazolium bis(trifluoromethylsulfonyl)imide ionic
liquid electrolyte. The device with 20 wt% of dendrimer with
respect to CNT content in the electrodes achieved a remarkable
increase of 600 % in capacitance compared with the capacitance
without the dendrimer
1D coordination polymer based on copper(II)-containing tetrameric 1,2,3- triazole ligand from click chemistry : magnetic and catalytic properties.
A novel tetrameric tetra[O-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)]-pentaerythritol (TBTP) has been synthesized using click chemistry strategy. TBTP was characterized and used as ligand to form new Cu(II) complexes, forming 1-D coordination polymers. Two square planar complexes were characterized by single-crystal X-ray diffraction, presenting formula [Cu(TBTP)][Cu(NO3)4] (1) and [Cu(TBTP)](NO3)2 (2). In both structures, a cationic 1-D coordination polymer (CP) has been formed. The CP contain a 1:1 Cu(II)/TBTP ratio with four neutral triazole groups coordinating the Cu(II) center, forming a CuN bonds ranging 1.988(2)?2.001(2)??. The study of the magnetic properties of compounds 1 and 2 pointed to an antiferromagnetic behavior for both compounds, defined by inter- and intra-chain dipolar interactions among their metallic centers. In addition, the complex 1 was found to be an efficient catalyst for selective oxidation of aniline to azobenzene under mild reaction conditions
Improvement of antimalarial activity of a 3-alkylpiridine alkaloid analog by replacing the pyridine ring to a thiazole-containing heterocycle : mode of action, mutagenicity profile, and Caco-2 cell-based permeability.
The development of new antimalarial drugs is urgent to overcome the spread of resistance to the current treatment. Herein we synthesized the compound 3, a hit-to?lead optimization of a thiazole based on the most promising 3-alkylpyridine marine alkaloid analog. Compound 3 was tested against Plasmodium falciparum and has shown to be more potent than its precursor (IC50 values of 1.55 and 14.7??M, respectively), with higher selectivity index (74.7) for noncancerous human cell line. This compound was not mutagenic and showed genotoxicity only at concentrations four-fold higher than its IC50. Compound 3 was tested in vivo against Plasmodium berghei NK65 strain and inhibited the development of parasite at 50?mg/kg. In silico and UV?vis approaches determined that compound 3 acts impairing hemozoin crystallization and confocal microscopy experiments corroborate these findings as the compound was capable of diminishing food vacuole acidity. The assay of uptake using human intestinal Caco-2 cell line showed that compound 3 is absorbed similarly to chloroquine, a standard antimalarial agent. Therefore, we present here compound 3 as a potent new lead antimalarial compound