Perinatal outcome in abnormal placental villus proliferation and mesenchymal dysplasia

Placental mesenchymal dysplasia (PMD) is a rare vascular anomaly which is characterized by mesenchymal stem villous hyperplasia and placentomegaly. Since the modality of treatment changes it is necessary to distinguish PMD from molar pregnancy, placenta mosaicism, chorioangioma, twin pregnancy with co-existent molar pregnancy. On reviewing cases of abnormal placental villus proliferation having features of placental mesenchymal hyperplasia placentomegaly and cystic appearance of placenta in database of our hospital from 2015-2019, we reported 4 cases of abnormal placental villous proliferation. And performed systematic review of existing literature. Provisional   diagnosis of PMD was made as USG and placental morphology showed 30-60% of the placenta with cystic vesicles, placentomegaly with a normal growing fetus. PMD an uncommon vascular anomaly which resembles molar pregnancy but prognosis is different. The fetus was normal in majority of the cases. This clinical entity should be kept in mind to avoid unnecessary termination of pregnancy