Effect of antibodies to glutamate on age-related memory changes in C57Bl/6 mice

Chronic intranasal administration of antibodies to glutamate to aging C57Bl/6 mice improved passive avoidance conditioning, had no effect on horizontal and vertical locomotor activity, but slowed locomotion in the open-field test. Administration of antibodies to glutamate increased the content of dopamine and its metabolites in mouse hippocampus, but had no effect on the metabolism of neurotransmitter amino acids. In the frontal cortex, antibodies to glutamate did not affect neurotransmitter metabolism, but increased the level of both excitatory and inhibitory amino acids without changing their ratio

Antibodies to glutamate reversed the amnesic effects of proinflammatory S100A9 protein fibrils in aged C57Bl/6 mice

Chronic intranasal administration of fibrillar structures of proinflammatory S100A9 protein impaired passive avoidance learning in old C57Bl/6 mice. Combined treatment with S100A9 fibrils and antibodies to glutamate was followed by an increase in horizontal locomotor activity of animals in the open-field test and did not disturb spatial memory

Delayed behavioral and neurochemical effects of anti-glutamate antibodies in aging C57BL/6 mice

We analyzed delayed effect of intranasal administration of anti-glutamate antibodies on mnestic function and tissue concentrations of neurotransmitters in the hippocampus and prefrontal cortex in aging C57BL/6 mice. It was found that after 14-day administration of anti-glutamate antibodies, improvement of the passive avoidance conditioning persisted for 7 days after the treatment was discontinued. In 7 days after discontinuation of treatment, increased content of dopamine and its metabolites as well as aspartic acid and taurine was observed in the hippocampus of mice treated with anti-glutamate antibodies. In the prefrontal cortex, administration of anti-glutamate antibodies had no effect on the levels of neurotransmitters, but increased the concentration of glutamate

SURGICAL TREATMENT FOR OSTEOPOROTIC SPINAL FRACTURES IN THE THORACO-LUMBAR SPINE AND AN ESTIMATION OF EFFICACY IN THE FOLLOW-UP

85 patients with osteoporotic vertebral fractures of lower thoracic and lumbar spine were operated. Surgical options including posterior reconstruction, anterior reconstruction and combined anterior and posterior surgery, vertebroplasty. In the postoperative period the great attention was given to rehabilitation and correction lowered BMD depending on osteoporosis type. The long-term outcomes were followed in 69%. Good results were achieved in 76% of cases, satisfactory - in 20%, unsatisfactory results - in 4%. The differential approach to surgical treatment osteoporotic spinal fractures in the thoraco-lumbar spine allows to restore in short terms stability of spine and return activity to patients