252 research outputs found
Redox-sensitive changes in conformation and cellular localization of LAT and downstream TCR signaling lead to hyporesponsiveness of synovial fluid T cells in rheumatoid arthritis
Management of Skin Toxicity Related to the Use of Imatinib Mesylate (STI571, Glivec™) for Advanced Stage Gastrointestinal Stromal Tumours
Skin toxicity is a common side-effect of treatment with imatinib mesylate (STI571, Glivec™) in advanced gastrointestinal
stromal tumours (GIST) and chronic myeloid leukaemia. The optimal duration of treatment with imatinib mesylate in
GIST has not yet been established, as durable remissions have been observed in patients. It is, therefore, important to
develop strategies to deal with common side-effects of what may be a long-term treatment. Here we report the case of a
patient with advanced GIST who developed a cutaneous drug reaction secondary to imatinib mesylate and the various
management options that may be employed depending upon the severity of the toxicity. The case and literature are
discussed
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