Music Education for Inclusion: The Call to the Musicians Professional Community in Russia: The Legal Professions in France and Russia.

International audienceRussian state in the post-perestroika period has come to the need for the economy of knowledge and society of equal opportunity. However this movement had created some contradictions in the professional musical community in Russia. Different teachers are oriented on different values. This situation set at variance between value orientation of elite music community and social oriented music teachers, who give support to children with health problems and disability. Аltruistic teachers have got rather strong reasons for their conclusions based on the researches carried out in the frames of musical therapy. Classes of altruistic teachers make it possible to resolve a wide range of problems. Тhe list of main special children's problems, which music lessons may solve, is the following: coordination problems; small motor function movements problems; speech disturbances; delayed response. Then we can demonstrate how these problems are solved during violin classes. Learning playing the violin is considered a hard process. There are several requirements to collective musical performance: communication and emotional contact with peers; the ability to organize their activities; concentration, involvement in the process. Potential of music therapy includes: Emotional contact with the teacher; No side effects from therapy; Violin tone; Development of fine motor skills; Reducing of muscle tension; both a teacher and a student are penetrated with the spirit of elite culture and great achievements. However, the violin is extremely useful for special children. In fact, there are no qualified teachers to work with them. Thus, educational programs require the participation of experts: musicians; sociologists; psychologists; social workers; trainers of special education

DC vaccines loaded with glioma cells killed by photodynamic therapy induce Th17 anti-tumor immunity and provide a four-gene signature for glioma prognosis

AbstractGliomas, the most frequent type of primary tumor of the central nervous system in adults, results in significant morbidity and mortality. Despite the development of novel, complex, multidisciplinary, and targeted therapies, glioma therapy has not progressed much over the last decades. Therefore, there is an urgent need to develop novel patient-adjusted immunotherapies that actively stimulate antitumor T cells, generate long-term memory, and result in significant clinical benefits. This work aimed to investigate the efficacy and molecular mechanism of dendritic cell (DC) vaccines loaded with glioma cells undergoing immunogenic cell death (ICD) induced by photosens-based photodynamic therapy (PS-PDT) and to identify reliable prognostic gene signatures for predicting the overall survival of patients. Analysis of the transcriptional program of the ICD-based DC vaccine led to the identification of robust induction of Th17 signature when used as a vaccine. These DCs demonstrate retinoic acid receptor-related orphan receptor-γt dependent efficacy in an orthotopic mouse model. Moreover, comparative analysis of the transcriptome program of the ICD-based DC vaccine with transcriptome data from the TCGA-LGG dataset identified a four-gene signature (CFH, GALNT3, SMC4, VAV3) associated with overall survival of glioma patients. This model was validated on overall survival of CGGA-LGG, TCGA-GBM, and CGGA-GBM datasets to determine whether it has a similar prognostic value. To that end, the sensitivity and specificity of the prognostic model for predicting overall survival were evaluated by calculating the area under the curve of the time-dependent receiver operating characteristic curve. The values of area under the curve for TCGA-LGG, CGGA-LGG, TCGA-GBM, and CGGA-GBM for predicting five-year survival rates were, respectively, 0.75, 0.73, 0.9, and 0.69. These data open attractive prospects for improving glioma therapy by employing ICD and PS-PDT-based DC vaccines to induce Th17 immunity and to use this prognostic model to predict the overall survival of glioma patients.</jats:p

Early dispersal of domestic horses into the Great Plains and northern Rockies

International audienceThe horse is central to many Indigenous cultures across the American Southwest and the Great Plains. However, when and how horses were first integrated into Indigenous lifeways remain contentious, with extant models derived largely from colonial records. We conducted an interdisciplinary study of an assemblage of historic archaeological horse remains, integrating genomic, isotopic, radiocarbon, and paleopathological evidence. Archaeological and modern North American horses show strong Iberian genetic affinities, with later influx from British sources, but no Viking proximity. Horses rapidly spread from the south into the northern Rockies and central plains by the first half of the 17th century CE, likely through Indigenous exchange networks. They were deeply integrated into Indigenous societies before the arrival of 18th-century European observers, as reflected in herd management, ceremonial practices, and culture

Early dispersal of domestic horses into the Great Plains and northern Rockies

The horse is central to many Indigenous cultures across the American Southwest and the Great Plains. However, when and how horses were first integrated into Indigenous lifeways remain contentious, with extant models derived largely from colonial records. We conducted an interdisciplinary study of an assemblage of historic archaeological horse remains, integrating genomic, isotopic, radiocarbon, and paleopathological evidence. Archaeological and modern North American horses show strong Iberian genetic affinities, with later influx from British sources, but no Viking proximity. Horses rapidly spread from the south into the northern Rockies and central plains by the first half of the 17th century CE, likely through Indigenous exchange networks. They were deeply integrated into Indigenous societies before the arrival of 18th-century European observers, as reflected in herd management, ceremonial practices, and culture.</p