Comment prévenir les complications de la cirrhose?

SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Mid-gut exploration: video-capsule endoscopy cannot always determine the insertion route of device-assisted enteroscopy

SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Fibroscan (Transient Elastography) is the most reliable non-invasive method for the assessment of severe fibrosis and cirrhosis in alcoholic liver disease

info:eu-repo/semantics/nonPublishe

Transient elastography using Fibroscan is the most reliable noninvasive method for the diagnosis of advanced fibrosis and cirrhosis in alcoholic liver disease.

Fibroscan (FS) is a reliable noninvasive method for the diagnosis of advanced fibrosis and cirrhosis in chronic liver disease. However, there is no clear consensus with respect to the best FS cut-off values for use in alcoholic liver disease (ALD). The aims of this study were as follows: (a) to compare the performance of FS and different biochemical markers in ALD patients; (b) to assess the best FS cut-off values for the prediction of fibrosis stage in our ALD population; and (c) to assess the influence of aspartate aminotransferase (AST) values on FS.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Fluctuating cholestasis in a 45-years-old man with polycystic kidney disease.

info:eu-repo/semantics/publishe

Gastrointestinal polypoid lesions: A poorly known endoscopic feature of portal hypertension

Aim: To describe a poorly known endoscopic entity associated with portal hypertension, characterized by polypoid lesions either in the stomach or small intestine of patients with cirrhosis. Methods: Between 2003 and 2012, patients with cirrhosis and portal hypertension underwent endoscopic workup of portal hypertension in our endoscopy unit. The clinical expression, endoscopic features of these lesions, and their pathological characteristics are described. Results: A total of 1538 patients were included, among which 14 (0.9%) presented polypoid lesions; these patients had evidence of portal hypertension and had dilated capillaries in the lamina propria. Four patients presented with severe anaemia or melaena and required treatment. Propranolol was administered to three patients, and one patient needed a transjugular intrahepatic portosystemic shunt in order to control bleeding. For asymptomatic patients in whom polypoid lesions were resected, no recurrence of lesions was observed during follow-up gastroscopy (median 36 months, range 7-85 months). Conclusion: Portal hypertension-associated gastric or small intestine polypoid lesions may be associated with a significant risk of bleeding and are responsive to adequate treatment of portal hypertension.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Fibroscan: the most reliable non invasive method to assess severe fibrosis and cirrhosis in ALD

info:eu-repo/semantics/nonPublishe

The predictive value of FIB-4 versus FibroTest, APRI, FibroIndex and forns index to noninvasively estimate fibrosis in hepatitis C and nonhepatitis C liver diseases

SCOPUS: le.jFLWINinfo:eu-repo/semantics/publishe

Safety evaluation and imaging properties of gadolinium-based nanoparticles in nonhuman primates

In this article, we report the safety evaluation of gadolinium-based nanoparticles in nonhuman primates (NHP) in the context of magnetic resonance imaging (MRI) studies in atherosclerosis bearing animals and healthy controls. In healthy NHP, the pharmacokinetics and toxicity profiles demonstrated the absence of dose, time, and sex-effects, as well as a suitable tolerance of intravenous administration of the nanoparticles. We investigated their imaging properties for arterial plaque imaging in a standard diet or a high cholesterol diet NHP, and compared their characteristics with clinically applied Gd-chelate. This preliminary investigation reports the efficient and safe imaging of atherosclerotic plaques

Prognostic evaluation of patients with parenchymal cirrhosis. Proposal of a new simple score

Background/aims: The current shortage of organs makes it desirable to establish the prognosis of patients with cirrhosis in order to assess priority for liver transplantation. Methods: We compared the utility of two exogenous tests (aminopyrine breath test and lidocaine metabolization test), two clinical parameters (encephalopathy, ascites), 18 endogenous tests and five scores (Pugh, Merkel, Orrego, Adler, Pignon) for predicting 1-year mortality in patients with parenchymal cirrhosis. Retrospective (n = 49 out of 63 patients) and prospective (n = 38 out of 46 patients) series were included. Univariate, multivariate, receiver operator curves and survival curves were employed. Results: We found that endogenous tests were more discriminant than exogenous tests. The best parameters of the univariate analysis (encephalopathy, bilirubin, alkaline phosphatase, cholinesterase and bile acids) and their 25th and 75th percentiles were included in an additive new score which turned out to be superior to the five other scores. Prospectively, the sensitivity of our new score compared to the Pugh score was 82% versus 95% (NS) and the specificity was 89% versus 56% (p < 0.01). Conclusions: Our new simple score appears to be very powerful for predicting prognosis at 1 year for patients with cirrhosis and should be evaluated in other centers.SCOPUS: ar.jinfo:eu-repo/semantics/publishe