629 research outputs found
A novel signalling mechanism regulating telomere length in cardiomyocytes
Clinical management and treatment of human diseases are continuously improving, with a progressive elongation of life expectancy in Western countries. As a consequence of the elevation of the average age of the population, the incidence of ageing-related diseases will progressively in- crease in the next years. Among ageing-related diseases, cardiovascular diseases still represent the first of cause of death in the Western world
Acute Treatment with Renal Denervation in a Patient with Resistant Hypertension and Hemorrhagic Stroke
A 49-year-old man with refractory hypertension was admitted
to our hospital in a coma caused by hemorrhagic stroke. Severe
hypertension was observed during hospitalization despite a full
antihypertensive therapy. Considering the risk of enlargement of
the intracranial hematoma, the decision was made to perform renal
denervation (RDN). A significant blood pressure reduction was
obtained after RDN. The patient had a progressive improvement of
general conditions and came out of the coma after a few days. This
case underlines the safety and the feasibility of RDN in a critically
ill patient
An Inhomogeneous Model for Laser Welding of Industrial Interest
An innovative non-homogeneous dynamic model is presented for the recovery of temperature during the industrial laser welding process of Al-Si (Formula presented.) alloy plates. It considers that, metallurgically, during welding, the alloy melts with the presence of solid/liquid phases until total melt is achieved, and afterwards it resolidifies with the reverse process. Further, a polynomial substitute thermal capacity of the alloy is chosen based on experimental evidence so that the volumetric solid-state fraction is identifiable. Moreover, to the usual radiative/convective boundary conditions, the contribution due to the positioning of the plates on the workbench is considered (endowing the model with Cauchy–Stefan–Boltzmann boundary conditions). Having verified the well-posedness of the problem, a Galerkin-FEM approach is implemented to recover the temperature maps, obtained by modeling the laser heat sources with formulations depending on the laser sliding speed. The results achieved show good adherence to the experimental evidence, opening up interesting future scenarios for technology transfer
Paclitaxel in endovascular devices. Identikit of a “serial killer”?
Recent developments in the management of peripheral artery disease have been momentous, and a key advance has been the
introduction of drug-coated balloons, which capitalise on the mechanical effects of angioplasty balloons, and on the pharmacologic effects of anti-restenotic drugs [1,2]. Indeed, single reports from randomized trials and pooled estimates from meta-analyses have clearly showed that paclitaxel-coated balloons reduce the risk of restenosis and repeat revascularization, while improving patency, limb salvage, and freedom from claudication
Veneto's successful lesson for a world shocked by COVID-19: think globally and act locally
Severe acute respiratory syndrome coronavirus 2 (SARSCoV-
2) infection has wreaked havoc globally, with an ominous
morbidity and mortality impact.1,2 Indeed, croronavirus
disease 2019 (COVID-19) still represents a formidable challenge
for pathophysiology, prognostication, management, and
rehabilitation. This holds even truer given the conflicting
reports accrued so far for several purportedly effective
interventions.1,3,4 Although substantial steps have been accomplished
in terms of diagnostic yield, even recognizing early
infection is still quite challenging. Each country has addressed
COVID-19 in its own way, with variable results. Perusing data
on China’s experience with the virus brings forward several
questions in terms of completeness and truthfulness of reporting,
with substantial skepticism despite several authoritative
reports.5 For instance, to date, China has reported fewer
COVID-19-related deaths than many smaller countries where
COVID-19 spread much later (eg, The Netherlands). Countries
and healthcare systems that have acted with a global vision,
but also with a firm and proactive local hand, have seen the
best results in terms of deaths and system derangement. Conversely,
countries with a loose policy (either initially such as
the United Kingdom or throughout such as Sweden) have
already paid an enormous toll of life and pain, and hypothetically
will continue to do so
Percutaneous coronary intervention driven by combined use of intracoronary anatomy and physiology Towards a tailored therapy for coronary artery disease
Coronary angiography classically allows a bidimensional evaluation
of the vascular lumen, however with many limitations in the case of eccentric
lesions, irregular contour or tortuosity of the vessel.Moreover, it
does not enable to assess neither the features of the vessel wall, nor the
functional significance of a lesion [1]. Newer technologies are available
to overcome these limitations.We present a case of percutaneous coronary
revascularization optimized by combined use of two of the most
widely used techniques
Successful Coronary Stent Retrieval From a Pedal Artery
The purpose of this article is to report complications
from a coronary drug-eluting stent lost in the
peripheral circulation. We report the case of successful
retrieval of a sirolimus coronary stent from a pedal artery in
a young patient who underwent coronary angiography for
previous anterior myocardial infarction. Recognition of
stent embolization requires adequate removal of the device
to avoid unwelcome clinical sequelae.
Keywords Coronary stent Microsnare technique
Peripheral embolization Stent retrieva
An exploratory study of MoS2 as anode material for potassium batteries
Potassium-based batteries represent one of the emerging classes of post-lithium electrochemical energy storage systems in the international scene, due to both the abundance of raw materials and achievable cell potentials not far from those of lithium batteries. In this context, it is important to define electrodes and electrolytes that give reproducible performance and that can be used by different research groups as an internal standard when developing new materials. We propose molybdenum disulfide (MoS2) as a valid anode choice, being a commercial and easily processable material, the 2D layered structure of which is promising for large potassium ions reversible storage. It has been proven to work for hundreds of cycles, keeping a constant specific capacity around 100 mAh g−1 while also preserving its electrochemical interphase and morphology
Comparison between intermediate and severe coronary stenoses and clinical outcomes of an OCT-guided PCI strategy
We compared optical coherence tomography (OCT) features of intermediate and severe coronary stenoses in patients with stable angina and acute coronary syndrome (ACS), and tested the clinical impact of an OCT-based strategy for treating intermediate stenoses
- …