4 research outputs found
ΠΠ¦ΠΠΠΠ ΠΠΠΠΠΠΠ‘ΠΠ―ΠΠ Π£Π ΠΠΠΠΠ ΠΠΠΠΠΠΠΠΠΠ, Π¦ΠΠ’ΠΠΠΠΠΠ, ΠΠΠ ΠΠΠ ΠΠ ΠΠΠ‘Π€Π£ΠΠΠ¦ΠΠ ΠΠΠΠΠ’ΠΠΠΠ― Π ΠΠΠΠΠΠΠ’ΠΠΠΠ ΠΠΠΠΠ‘Π’ΠΠΠ Π‘ Π‘ΠΠ‘Π’ΠΠ―ΠΠΠΠ ΠΠ ΠΠΠΠΠ-ΠΠΠ¨ΠΠΠΠ ΠΠ Π Π‘ΠΠ§ΠΠ’ΠΠΠΠ ΠΠ Π’ΠΠ ΠΠΠΠ¬ΠΠΠ ΠΠΠΠΠ Π’ΠΠΠΠΠ Π‘ ΠΠΠΠΠΠΠΠΠΠ¬ΠΠ«Π ΠΠΠΠ ΠΠΠΠΠ Π£ ΠΠΠ¦ ΠΠΠΠΠΠΠΠ ΠΠΠΠ ΠΠ‘Π’Π
Background. To estimate the correlation of adipokines, cytokines, endothelial dysfunction markers and hemostasis with state of target organs in young patients with hypertension and abdominal obesity.Materials and methods. The blood content of adipokines, cytokines, endothelial dysfunction markers and hemostasis in patients with hypertension, abdominal obesity and their combination was determined. Standard 12-lead ECG, two-dimensional echocardiography and duplex scanning of the brachiocephalic arteries were performed in all patients.Results. In young patients with combination of hypertension and abdominal obesity were determined the increased levels of leptin, interleukin-6, monocyte chemoattractant protein type 1, endothelin, angiotensin II and prothrombotic changes in hemostasis. Among this patients were revealed hypertrophy of the left ventricle myocardium and increased intima-media complex thickness compared to those in groups with isolated hypertension, isolated abdominal obesity and the control group. The greatest diagnostic significance for predicting myocardial hypertrophy of the left ventricle according to the ROC-analysis were endothelin level >3,49 pg/ml and interleukin-6 level >5,67 pg/ml.Π¦Π΅Π»Ρ. ΠΏΡΠΎΠ²Π΅ΡΡΠΈ ΠΎΡΠ΅Π½ΠΊΡ Π²Π·Π°ΠΈΠΌΠΎΡΠ²ΡΠ·ΠΈ ΡΡΠΎΠ²Π½Π΅ΠΉ Π°Π΄ΠΈΠΏΠΎΠΊΠΈΠ½ΠΎΠ², ΡΠΈΡΠΎΠΊΠΈΠ½ΠΎΠ², ΠΌΠ°ΡΠΊΠ΅ΡΠΎΠ² Π΄ΠΈΡΡΡΠ½ΠΊΡΠΈΠΈ ΡΠ½Π΄ΠΎΡΠ΅Π»ΠΈΡ ΠΈ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ Π³Π΅ΠΌΠΎΡΡΠ°Π·Π° Ρ ΡΠΎΡΡΠΎΡΠ½ΠΈΠ΅ΠΌ ΠΎΡΠ³Π°Π½ΠΎΠ²-ΠΌΠΈΡΠ΅Π½Π΅ΠΉ Ρ Π»ΠΈΡ ΠΌΠΎΠ»ΠΎΠ΄ΠΎΠ³ΠΎ Π²ΠΎΠ·ΡΠ°ΡΡΠ° Ρ Π°ΡΡΠ΅ΡΠΈΠ°Π»ΡΠ½ΠΎΠΉ Π³ΠΈΠΏΠ΅ΡΡΠ΅Π½Π·ΠΈΠ΅ΠΉ Π² ΡΠΎΡΠ΅ΡΠ°Π½ΠΈΠΈ Ρ Π°Π±Π΄ΠΎΠΌΠΈΠ½Π°Π»ΡΠ½ΡΠΌ ΠΎΠΆΠΈΡΠ΅Π½ΠΈΠ΅ΠΌ.ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΠ°ΡΠΈΠ΅Π½ΡΠ°ΠΌ Ρ ΠΈΠ·ΠΎΠ»ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ Π°ΡΡΠ΅ΡΠΈΠ°Π»ΡΠ½ΠΎΠΉ Π³ΠΈΠΏΠ΅ΡΡΠ΅Π½Π·ΠΈΠ΅ΠΉ ΠΈ ΠΈΠ·ΠΎΠ»ΠΈΡΠΎΠ²Π°Π½Π½ΡΠΌ Π°Π±Π΄ΠΎΠΌΠΈΠ½Π°Π»ΡΠ½ΡΠΌ ΠΎΠΆΠΈΡΠ΅Π½ΠΈΠ΅ΠΌ, Π° ΡΠ°ΠΊΠΆΠ΅ Ρ ΠΈΡ
ΡΠΎΡΠ΅ΡΠ°Π½ΠΈΠ΅ΠΌ Π² ΠΊΡΠΎΠ²ΠΈ ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ»ΠΈ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅ Π°Π΄ΠΈΠΏΠΎΠΊΠΈΠ½ΠΎΠ², ΡΠΈΡΠΎΠΊΠΈΠ½ΠΎΠ², ΠΌΠ°ΡΠΊΠ΅ΡΠΎΠ² Π΄ΠΈΡΡΡΠ½ΠΊΡΠΈΠΈ ΡΠ½Π΄ΠΎΡΠ΅Π»ΠΈΡ ΠΈ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ Π³Π΅ΠΌΠΎΡΡΠ°Π·Π°. ΠΠ»Ρ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΠΉ ΠΎΡΠ³Π°Π½ΠΎΠ²-ΠΌΠΈΡΠ΅Π½Π΅ΠΉ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈΡΡ: ΡΡΠ°Π½Π΄Π°ΡΡΠ½Π°Ρ ΠΠΠ Π² 12-ΡΠΈ ΠΎΡΠ²Π΅Π΄Π΅Π½ΠΈΡΡ
, ΡΡ
ΠΎΠΊΠ°ΡΠ΄ΠΈΠΎΠ³ΡΠ°ΡΠΈΡ, Π΄ΡΠΏΠ»Π΅ΠΊΡΠ½ΠΎΠ΅ ΡΠΊΠ°Π½ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ Π±ΡΠ°Ρ
ΠΈΠΎΡΠ΅ΡΠ°Π»ΡΠ½ΡΡ
Π°ΡΡΠ΅ΡΠΈΠΉ.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΠ΅ ΡΡΠΎΠ²Π½Ρ Π»Π΅ΠΏΡΠΈΠ½Π°, ΠΈΠ½ΡΠ΅ΡΠ»Π΅ΠΉΠΊΠΈΠ½Π°-6 ΠΈ ΠΌΠΎΠ½ΠΎΡΠΈΡΠ°ΡΠ½ΠΎΠ³ΠΎ Ρ
Π΅ΠΌΠΎΠ°ΡΡΡΠ°ΠΊΡΠ°Π½ΡΠ½ΠΎΠ³ΠΎ ΠΏΡΠΎΡΠ΅ΠΈΠ½Π° 1 ΡΠΈΠΏΠ°, ΡΠ½Π΄ΠΎΡΠ΅Π»ΠΈΠ½Π° ΠΈ Π°Π½Π³ΠΈΠΎΡΠ΅Π½Π·ΠΈΠ½Π° II, Π° ΡΠ°ΠΊΠΆΠ΅ ΠΏΡΠΎΡΡΠΎΠΌΠ±ΠΎΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ Π³Π΅ΠΌΠΎΡΡΠ°Π·Π° Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΡΠΎΡΠ΅ΡΠ°Π½ΠΈΠ΅ΠΌ Π°ΡΡΠ΅ΡΠΈΠ°Π»ΡΠ½ΠΎΠΉ Π³ΠΈΠΏΠ΅ΡΡΠ΅Π½Π·ΠΈΠΈ ΠΈ Π°Π±Π΄ΠΎΠΌΠΈΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΎΠΆΠΈΡΠ΅Π½ΠΈΡ. Π‘ΡΠ΅Π΄ΠΈ ΠΈΡΡΠ»Π΅Π΄ΡΠ΅ΠΌΡΡ
ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² ΡΠ°ΡΠ΅ Π²ΡΡΠ²Π»ΡΠ»ΠΈΡΡ Π³ΠΈΠΏΠ΅ΡΡΡΠΎΡΠΈΡ ΠΌΠΈΠΎΠΊΠ°ΡΠ΄Π° Π»Π΅Π²ΠΎΠ³ΠΎ ΠΆΠ΅Π»ΡΠ΄ΠΎΡΠΊΠ° ΠΈ ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΠ΅ ΡΠΎΠ»ΡΠΈΠ½Ρ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ° ΠΈΠ½ΡΠΈΠΌΠ°-ΠΌΠ΅Π΄ΠΈΠ° ΠΏΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ Ρ ΡΠ°ΠΊΠΎΠ²ΡΠΌΠΈ Π² Π³ΡΡΠΏΠΏΠ°Ρ
Ρ ΠΈΠ·ΠΎΠ»ΠΈΡΠΎΠ²Π°Π½Π½ΡΠΌΠΈ Π°ΡΡΠ΅ΡΠΈΠ°Π»ΡΠ½ΠΎΠΉ Π³ΠΈΠΏΠ΅ΡΡΠ΅Π½Π·ΠΈΠ΅ΠΉ ΠΈ Π°Π±Π΄ΠΎΠΌΠΈΠ½Π°Π»ΡΠ½ΡΠΌ ΠΎΠΆΠΈΡΠ΅Π½ΠΈΠ΅ΠΌ, Π° ΡΠ°ΠΊΠΆΠ΅ ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½ΠΎΠΉ Π³ΡΡΠΏΠΏΠΎΠΉ. ΠΠ°ΠΈΠ±ΠΎΠ»ΡΡΠ΅ΠΉ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π·Π½Π°ΡΠΈΠΌΠΎΡΡΡΡ Π΄Π»Ρ ΠΏΡΠΎΠ³Π½ΠΎΠ·ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΡΠ°Π·Π²ΠΈΡΠΈΡ Π³ΠΈΠΏΠ΅ΡΡΡΠΎΡΠΈΠΈ ΠΌΠΈΠΎΠΊΠ°ΡΠ΄Π° Π»Π΅Π²ΠΎΠ³ΠΎ ΠΆΠ΅Π»ΡΠ΄ΠΎΡΠΊΠ° ΠΏΠΎ Π΄Π°Π½Π½ΡΠΌ ROC-Π°Π½Π°Π»ΠΈΠ·Π° ΠΎΠΊΠ°Π·Π°Π»ΠΈΡΡ ΡΡΠΎΠ²Π΅Π½Ρ ΡΠ½Π΄ΠΎΡΠ΅Π»ΠΈΠ½Π° >3,49 ΠΏΠ³/ΠΌΠ» ΠΈ ΡΡΠΎΠ²Π΅Π½Ρ ΠΈΠ½ΡΠ΅ΡΠ»Π΅ΠΉΠΊΠΈΠ½Π°-6 >5,67 ΠΏΠ³/ΠΌΠ»
Association between Carotid Wall Shear Rate and Arterial Stiffness in Patients with Hypertension and Atherosclerosis of Peripheral Arteries
Aim. To evaluate carotid wall shear rate (WSR) in association with local and regional vascular stiffness in patients with hypertension (HTN) and atherosclerosis of peripheral arteries and to study the pattern of change of WSR in patients with HTN with increasing severity of peripheral artery atherosclerosis. Materials and Methods. Study involved 133 patients with HTN, 65 men and 48 women, aged in average 57.9Β±10.8 years. All patients were divided into four groups in accordance with ultrasound morphologic classification of vessel wall. Duplex scanning of carotid and lower limb arteries was performed. Carotid-femoral (cfPWV) and carotid-radial (crPWV) pulse wave velocity (PWV) were measured. Local carotid stiffness was evaluated by carotid ultrasound. Results. WSR of patients with plaques without and with hemodynamic disturbance was 416Β±128βsβ1 and 405Β±117βsβ1, respectively, which was significantly less than the WSR in patients with intact peripheral arteries β 546Β±112βsβ1. Decreased carotid WSR was associated with increased crPVW, cfPWV, Petersonβs elastic modulus, decreased distensibility, and distensibility coefficient. Conclusion. In patients with HTN and atherosclerotic lesions of peripheral arteries, it is registered that the carotid WSR decreased with increasing severity of atherosclerosis. Decreased carotid WSR is associated with increased local carotid stiffness, regional vascular stiffness of muscular, and elastic vessels
Circulating Ageing Neutrophils as a Marker of Asymptomatic Polyvascular Atherosclerosis in Statin-NaΓ―ve Patients without Established Cardiovascular Disease
Background: Current data on the possible involvement of aging neutrophils in atherogenesis are limited. This study aimed to research the diagnostic value of aging neutrophils in their relation to subclinical atherosclerosis in statin-naΓ―ve patients without established atherosclerotic cardiovascular diseases (ASCVD). Methods: The study was carried out on 151 statin-naΓ―ve patients aged 40β64 years old without ASCVD. All patients underwent duplex scanning of the carotid arteries, lower limb arteries and abdominal aorta. Phenotyping and differentiation of neutrophil subpopulations were performed through flow cytometry (Navios 6/2, Beckman Coulter, USA). Results: The number of CD62LloCXCR4hi-neutrophils is known to be significantly higher in patients with subclinical atherosclerosis compared with patients without atherosclerosis (p = 0.006). An increase in the number of CD62LloCXCR4hi-neutrophils above cut-off values makes it possible to predict atherosclerosis in at least one vascular bed with sensitivity of 35.4β50.5% and specificity of 80.0β92.1%, in two vascular beds with sensitivity of 44.7β84.4% and specificity of 80.8β33.3%. Conclusion: In statin-naΓ―ve patients 40β64 years old without established ASCVD with subclinical atherosclerosis, there is an increase in circulating CD62LloCXCR4hi-neutrophils. It was also concluded that the increase in the number of circulating CD62LloCXCR4hi-neutrophils demonstrated moderate diagnostic efficiency (AUC 0.617β0.656) in relation to the detection of subclinical atherosclerosis, including polyvascular atherosclerosis
Evaluation of the hemostatic state, carbohydrate and lipid metabolism in young women with abdominal obesity and hypertension
Aim of this study was to determine the characteristics of the laboratory parameters of hemostasis, carbohydrate and lipid metabolism in women with metabolic syndrome, isolated abdominal obesity or with hypertension.Materials and methods. The study included 71 women aged 30 β 44 years and was conducted at laboratory study of hemostasis system, carbohydrate and lipid metabolism.Results. In women with abdominal obesity and arterial hypertension we found an increased levels of glucose, total cholesterol, LDL-C and triglycerides and a decrease in a concentration of HDL-C compared to healthy women. The study of hemostasis revealed prothrombotic changes in the form of activation of coagulation hemostasis and fibrinolysis system activity.Conclusions. The disorders of carbohydrate and lipid metabolism are very prevalent in young women with abdominal obesity and hypertension with every second woman meeting the criteria for the metabolic syndrome. The most pronounced signs of activation of blood coagulation markes was seen in women with abdominal obesity and hypertension. In women with the individual components of the metabolic syndrome there were no significant changes in carbohydrate and lipid metabolism, although we saw an early signs of activation of hemocoagulation