An application of skew frequency curves to river stages

Floods have occurred in the past and will occur again in the future. References to floods are incorporated in some of the early writings of man. Unfortunately though man has recorded the event, he has seldom recorded facts whereby it is possible to determine the volume of flow or the height to which the water rose. Where man has recorded the height to which water rose, much data such as channel conditions, vegetation coverage on the flood plain, etc., remains vague or unknown. It has been only in comparatively recent times with the advent of the steamboat that man has systematically recorded information regarding river stages and approached the problem in a logical manner. The period of record for most of the rivers of the united states, however, can be placed at well under one hundred years. One hundred years of record for a phenomena with causes as complex as those causing floods is meager compared to the vast volume of unrecorded events. The engineer, however, must take recorded fact and make has predictions. This paper is written concerning records of less than one hundred years and a method used to establish flood levels upon which engineering structures could be designed --Preface, page iii

Social encounter networks : characterizing Great Britain

A major goal of infectious disease epidemiology is to understand and predict the spread of infections within human populations, with the intention of better informing decisions regarding control and intervention. However, the development of fully mechanistic models of transmission requires a quantitative understanding of social interactions and collective properties of social networks. We performed a cross-sectional study of the social contacts on given days for more than 5000 respondents in England, Scotland and Wales, through postal and online survey methods. The survey was designed to elicit detailed and previously unreported measures of the immediate social network of participants relevant to infection spread. Here, we describe individual-level contact patterns, focusing on the range of heterogeneity observed and discuss the correlations between contact patterns and other socio-demographic factors. We find that the distribution of the number of contacts approximates a power-law distribution, but postulate that total contact time (which has a shorter-tailed distribution) is more epidemiologically relevant. We observe that children, public-sector and healthcare workers have the highest number of total contact hours and are therefore most likely to catch and transmit infectious disease. Our study also quantifies the transitive connections made between an individual's contacts (or clustering); this is a key structural characteristic of social networks with important implications for disease transmission and control efficacy. Respondents' networks exhibit high levels of clustering, which varies across social settings and increases with duration, frequency of contact and distance from home. Finally, we discuss the implications of these findings for the transmission and control of pathogens spread through close contact

Simultaneous effects on parvalbumin-positive interneuron and dopaminergic system development in a transgenic rat model for sporadic schizophrenia

To date, unequivocal neuroanatomical features have been demonstrated neither for sporadic nor for familial schizophrenia. Here, we investigated the neuroanatomical changes in a transgenic rat model for a subset of sporadic chronic mental illness (CMI), which modestly overexpresses human full-length, non-mutant Disrupted-in-Schizophrenia 1 (DISC1), and for which aberrant dopamine homeostasis consistent with some schizophrenia phenotypes has previously been reported. Neuroanatomical analysis revealed a reduced density of dopaminergic neurons in the substantia nigra and reduced dopaminergic fibres in the striatum. Parvalbumin-positive interneuron occurrence in the somatosensory cortex was shifted from layers II/III to V/VI, and the number of calbindin-positive interneurons was slightly decreased. Reduced corpus callosum thickness confirmed trend-level observations from in vivo MRI and voxel-wise tensor based morphometry. These neuroanatomical changes help explain functional phenotypes of this animal model, some of which resemble changes observed in human schizophrenia post mortem brain tissues. Our findings also demonstrate how a single molecular factor, DISC1 overexpression or misassembly, can account for a variety of seemingly unrelated morphological phenotypes and thus provides a possible unifying explanation for similar findings observed in sporadic schizophrenia patients. Our anatomical investigation of a defined model for sporadic mental illness enables a clearer definition of neuroanatomical changes associated with subsets of human sporadic schizophrenia

A resonance tunable and durable LSPR nano-particle sensor : AL2O3 capped silver nano-disks

Localized surface plasmon resonance (LSPR) biosensors are employed to detect target biomolecules which have particular resonance wavelengths. Accordingly, tunability of the LSPR wavelength is essential in designing LSPR devices. LSPR devices employing silver nano-particles present better efficiencies than those using other noble metals such as gold; however, silver nano-particles are easily oxidized when they come in contact with liquids, which is inevitable in biosensing applications. To attain both durability and tunabilty in a LSPR biosensor, this paper proposes alumina (AL2O3) capped silver nano-disks. It is shown that through controlling the thickness of the cap, the LSPR resonance frequency can be finely tuned over a wide range; and moreover, the cap protects silver nano-particles from oxidation and high temperature.<br /

Investigation of external refrigeration systems for long term cryogenic storage Final report

Data on external refrigeration systems for space storage of cryogens for long period

Investigation of external refrigeration systems for long-term cryogenic storage

Evaluation of cryogenic refrigeration systems for space application

Truly unentangled photon pairs without spectral filtering

We demonstrate that an integrated silicon microring resonator is capable of efficiently producing photon pairs that are completely unentangled; such pairs are a key component of heralded single photon sources. A dual-channel interferometric coupling scheme can be used to independently tune the quality factors associated with the pump and signal and idler modes, yielding a biphoton wavefunction with Schmidt number arbitrarily close to unity. This will permit the generation of heralded single photon states with unit purity.Comment: 5 pages, 3 figure