Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases

The production of peroxide and superoxide is an inevitable consequence of aerobic metabolism, and while these particular "reactive oxygen species" (ROSs) can exhibit a number of biological effects, they are not of themselves excessively reactive and thus they are not especially damaging at physiological concentrations. However, their reactions with poorly liganded iron species can lead to the catalytic production of the very reactive and dangerous hydroxyl radical, which is exceptionally damaging, and a major cause of chronic inflammation. We review the considerable and wide-ranging evidence for the involvement of this combination of (su)peroxide and poorly liganded iron in a large number of physiological and indeed pathological processes and inflammatory disorders, especially those involving the progressive degradation of cellular and organismal performance. These diseases share a great many similarities and thus might be considered to have a common cause (i.e. iron-catalysed free radical and especially hydroxyl radical generation). The studies reviewed include those focused on a series of cardiovascular, metabolic and neurological diseases, where iron can be found at the sites of plaques and lesions, as well as studies showing the significance of iron to aging and longevity. The effective chelation of iron by natural or synthetic ligands is thus of major physiological (and potentially therapeutic) importance. As systems properties, we need to recognise that physiological observables have multiple molecular causes, and studying them in isolation leads to inconsistent patterns of apparent causality when it is the simultaneous combination of multiple factors that is responsible. This explains, for instance, the decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference

Successful treatment of a severe cyanide salts intoxication using hydroxocobalamine and thiosulfate: Case report and hemodynamic study

Organized by the Belgian Society of Intensive Care and Emergency Medicineinfo:eu-repo/semantics/nonPublishe

Survival after severe cyanide salts poisoning

info:eu-repo/semantics/nonPublishe

Actualités en cancérologie pulmonaire

info:eu-repo/semantics/publishe

Tabagisme, carcinogenèse: dépistage et traitement précoce

info:eu-repo/semantics/publishe

Diagnostic et traitement du cancer bronchique au stade précoce :État de la question

SCOPUS: re.jinfo:eu-repo/semantics/publishe

Detection of bronchial preneoplastic lesions and early lung cancer with fluorescence bronchoscopy: A study about its ambulatory feasibility under local anaesthesis

Background: Autofluorescence bronchoscopy (AB) enhances the bronchoscopist's ability to diagnose bronchial preneoplastic lesions and early cancer. We undertook a study to assess its feasibility and performance under local anaesthesia on a real ambulatory mode. Methods: Thirty-four consecutive patients at very high risk for lung cancer were prospectively studied by AB under local anaesthesia, without any sedation. Lidocaine doses, time, oxygen saturation, peak expiratory flow (PEF) and the number of cough episodes were measured. Continuous assessment of the respiratory sensation was obtained with a visual analog scale. A total of 172 biopsies were performed in abnormal and normal areas. Results: The procedure was long-lasting (mean±SD: 26.6±6.0 min), required high total doses of Lidocaine (660±107 mg) without any significant side effect, and was associated with significant decreases in O2 saturation from 98.5±1.4 to 96.1±2.5% and in PEF from 380±96 to 310±78 l/min. However, the cough counts were moderate and the majority of patients reported no respiratory discomfort. 62 hyperplasia, metaplasia, dysplasia and carcinoma in situ (CIS) were detected and the relative sensitivity of AB+white-light bronchoscopy (WLB) versus WLB alone was 3.75 for intraepithelial lesions corresponding to moderate dysplasia or worse. Conclusions: AB, a procedure that increases our ability to recognize preneoplastic lesions and early lung cancer, can be performed under local anaesthesia, without systemic sedation in patients at very high risk for lung cancer. Copyright (C) 1999 Elsevier Science Ireland Ltd.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Characteristics and management of occult carcinomas of the lung: experience of autofluorescence bronchoscopy

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Familial essential thrombocythemia.

We report three siblings (2 F, 1 M) aged 9, 12, and 15 years with a thrombocytosis, above 650 X 10(9)/l for at least 18 months and a leukocyte alkaline phosphatase score below 37. The diagnosis of essential thrombocythemia was based upon the exclusion of a reactive thrombocytosis or another myeloproliferative disease. Cytogenetic examination of marrow cells was normal.Journal Articleinfo:eu-repo/semantics/publishe

Synchronous roentgenographically occult lung carcinoma in patients with resectable primary lung cancer

SCOPUS: ar.jinfo:eu-repo/semantics/publishe