GPU-Based Data Processing for 2-D Microwave Imaging on MAST

The Synthetic Aperture Microwave Imaging (SAMI) diagnostic is a Mega Amp Spherical Tokamak (MAST) diagnostic based at Culham Centre for Fusion Energy. The acceleration of the SAMI diagnostic data-processing code by a graphics processing unit is presented, demonstrating acceleration of up to 60 times compared to the original IDL (Interactive Data Language) data-processing code. SAMI will now be capable of intershot processing allowing pseudo-real-time control so that adjustments and optimizations can be made between shots. Additionally, for the first time the analysis of many shots will be possible

An Interspecific Nicotiana Hybrid as a Useful and Cost-Effective Platform for Production of Animal Vaccines

The use of transgenic plants to produce novel products has great biotechnological potential as the relatively inexpensive inputs of light, water, and nutrients are utilised in return for potentially valuable bioactive metabolites, diagnostic proteins and vaccines. Extensive research is ongoing in this area internationally with the aim of producing plant-made vaccines of importance for both animals and humans. Vaccine purification is generally regarded as being integral to the preparation of safe and effective vaccines for use in humans. However, the use of crude plant extracts for animal immunisation may enable plant-made vaccines to become a cost-effective and efficacious approach to safely immunise large numbers of farm animals against diseases such as avian influenza. Since the technology associated with genetic transformation and large-scale propagation is very well established in Nicotiana, the genus has attributes well-suited for the production of plant-made vaccines. However the presence of potentially toxic alkaloids in Nicotiana extracts impedes their use as crude vaccine preparations. In the current study we describe a Nicotiana tabacum and N. glauca hybrid that expresses the HA glycoprotein of influenza A in its leaves but does not synthesize alkaloids. We demonstrate that injection with crude leaf extracts from these interspecific hybrid plants is a safe and effective approach for immunising mice. Moreover, this antigen-producing alkaloid-free, transgenic interspecific hybrid is vigorous, with a high capacity for vegetative shoot regeneration after harvesting. These plants are easily propagated by vegetative cuttings and have the added benefit of not producing viable pollen, thus reducing potential problems associated with bio-containment. Hence, these Nicotiana hybrids provide an advantageous production platform for partially purified, plant-made vaccines which may be particularly well suited for use in veterinary immunization programs

Prognostic refinement of NSMP high-risk endometrial cancers using oestrogen receptor immunohistochemistry

Background: Risk-assessment of endometrial cancer (EC) is based on clinicopathological factors and molecular subgroup. It is unclear whether adding hormone receptor expression, L1CAM expression or CTNNB1 status yields prognostic refinement. Methods: Paraffin-embedded tumour samples of women with high-risk EC (HR-EC) from the PORTEC-3 trial (n = 424), and a Dutch prospective clinical cohort called MST (n = 256), were used. All cases were molecularly classified. Expression of L1CAM, ER and PR were analysed by whole-slide immunohistochemistry and CTNNB1 mutations were assessed with a next-generation sequencing. Kaplan-Meier method, log-rank tests and Cox's proportional hazard models were used for survival analysis. Results: In total, 648 HR-EC were included. No independent prognostic value of ER, PR, L1CAM, and CTNNB1 was found, while age, stage, and adjuvant chemotherapy had an independent impact on risk of recurrence. Subgroup-analysis showed that only in NSMP HR-EC, ER-positivity was independently associated with a reduced risk of recurrence (HR 0.33, 95%CI 0.15-0.75). Conclusions: We confirmed the prognostic impact of the molecular classification, age, stage, and adjuvant CTRT in a large cohort of high-risk EC. ER-positivity is a strong favourable prognostic factor in NSMP HR-EC and identifies a homogeneous subgroup of NSMP tumours. Assessment of ER status in high-risk NSMP EC is feasible in clinical practice and could improve risk stratification and treatment.Biological, physical and clinical aspects of cancer treatment with ionising radiatio

Clinical Behavior and Molecular Landscape of Stage I p53-Abnormal Low-Grade Endometrioid Endometrial Carcinomas

PURPOSE: The clinical significance of the p53-abnormal (p53abn) molecular subtype in stage I low-grade endometrioid endometrial carcinoma (EEC) is debated. We aimed to review pathologic and molecular characteristics, and outcomes of stage I low-grade p53abn EEC in a large international cohort. EXPERIMENTAL DESIGN: Previously diagnosed stage I p53abn EC (POLE-wild-type, mismatch repair-proficient) low-grade EEC from Canadian retrospective cohorts and PORTEC-1&2 trials were included. Pathology review was performed by six expert gynecologic pathologists blinded to p53 status. IHC profiling, next-generation sequencing, and shallow whole-genome sequencing was performed. Kaplan-Meier method was used for survival analysis. RESULTS: We identified 55 stage I p53abn low-grade EEC among 3,387 cases (2.5%). On pathology review, 17 cases (31%) were not diagnosed as low-grade EEC by any pathologists, whereas 26 cases (47%) were diagnosed as low-grade EEC by at least three pathologists. The IHC and molecular profile of the latter cases were consistent with low-grade EEC morphology (ER/PR positivity, patchy p16 expression, PIK3CA and PTEN mutations) but they also showed features of p53abn EC (TP53 mutations, many copy-number alterations). These cases had a clinically relevant risk of disease recurrence (5-year recurrence-free survival 77%), with pelvic and/or distant recurrences observed in 12% of the patients. CONCLUSIONS: A subset of p53abn EC is morphologically low-grade EEC and exhibit genomic instability. Even for stage I disease, p53abn low-grade EEC are at substantial risk of disease recurrence. These findings highlight the clinical relevance of universal p53-testing, even in low-grade EEC, to identify women at increased risk of recurrence

Trusting Former Rebels: An Experimental Approach to Understanding Reintegration after Civil War

The stability of many post-conflict societies rests on the successful reintegration of former soldiers. We examine social capital of former soldiers in Northern Uganda, where the Lord's Resistance Army forcibly recruited tens of thousands of youth during a recent brutal conflict. We use a set of interlocked experiments to study behavior of ex-soldiers jointly with the behavior of receiving communities towards this group. Consistent with theories that highlight the importance of cooperation during war, we find that individual cooperativeness robustly increases with the length of time a person was with the LRA, especially among those who were abducted during early age. Furthermore, parents of former-soldiers are aware of the behavioral difference: they trust ex-soldiers more because they expect them to be more trustworthy. Last, we find no evidence of preference-based discrimination, suggesting that anger is attenuated when communities do not attribute responsibility for committed violence to returning soldiers. Together, the results reveal that the impact of child soldiering on social capital, in contrast to human capital, is not necessarily detrimental and, speculatively, may facilitate reintegration

Milieuhygienische kwaliteit van primaire en secundaire bouwmaterialen in relatie tot hergebruik en bodem- en oppervlaktewaterenbescherming

To support the General Administrative Order on Construction Materials (Soil and Surface Waters Protection) this document supplies information on: 1) the quantification of the standard values for the application of construction materials ; 2) the environmental quality (characterization) of construction materials ; ; 3) the consequenses for use and re-use of construction materials.Ter ondersteuning van het Bouwstoffenbesluit (Bodem en Oppervlaktewateren Bescherming) levert dit rapport de volgende informatie: 1) de bepaling van de normwaarden voor het gebruik van bouwmaterialen ; 2) de milieukwaliteit (karakterisering) van de bouwmaterialen ; 3) het resultaat voor het gebruik en het hergebruik van bouwmaterialen

[Environmental quality of primary and secondary building materials in relation to re-use, soil protection and surface waters protection. Appendix A, B en C]

Tevens RIZA rapportnr. 93.042.<br>Ter ondersteuning van het Bouwstoffenbesluit (Bodem en Oppervlaktewateren Bescherming) levert dit rapport de volgende informatie: 1) de bepaling van de normwaarden voor het gebruik van bouwmaterialen ; 2) de milieukwaliteit (karakterisering) van de bouwmaterialen ; 3) het resultaat voor het gebruik en het hergebruik van bouwmaterialen.This report supports the General Administrative Order on Building Materials (Soil- and Surface Waters Protection). The report supplies information on: - The quantification of the standard values for the application of building materials. - The environmental quality (characterization) of building materials. - The consequences for use and re-use of building materials.DGM/B

Milieuhygienische kwaliteit van primaire en secundaire bouwmaterialen in relatie tot hergebruik en bodem- en oppervlaktewaterenbescherming

Ter ondersteuning van het Bouwstoffenbesluit (Bodem en Oppervlaktewateren Bescherming) levert dit rapport de volgende informatie: 1) de bepaling van de normwaarden voor het gebruik van bouwmaterialen ; 2) de milieukwaliteit (karakterisering) van de bouwmaterialen ; 3) het resultaat voor het gebruik en het hergebruik van bouwmaterialen.To support the General Administrative Order on Construction Materials (Soil and Surface Waters Protection) this document supplies information on: 1) the quantification of the standard values for the application of construction materials ; 2) the environmental quality (characterization) of construction materials ; ; 3) the consequenses for use and re-use of construction materials.DGM/B