Pedestrian Flow Characteristics at Upstream and Downstream of Bottleneck for Unidirectional Flow under Normal Conditions

The study of pedestrian flow characteristics at upstream and downstream of bottlenecks is important from level of service and evacuation perspective. Many controlled laboratory experiments have been conducted to study pedestrians’ behavior at bottlenecks. However, it is unclear whether experiments can reproduce real crowd flow characteristics. In this paper, real field data was collected at normal conditions for unidirectional pedestrian movement at Mahakaleshwar, a Hindu temple at Ujjain, India during Mahashivaratri, a festival day on which a large number of pilgrims visited the temple. Along the corridor there is a width reduction at a U-turn which creates a bottleneck. It is necessary to study pedestrian flow characteristics at bottlenecks to ensure desired level of service at temple premises during heavy flow. The speed-density relationships of upstream and downstream sections were compared and it was found that flow behavior at both the sections of bottleneck severely differ from each other. Pedestrians in the upstream are either at free flow speed for very low density values or moving slowly for intermediate to high range of density values. From the speed-density relationship, it can be concluded that pedestrians at upstream had visual clues of congestion ahead at bottleneck (pedestrian could also see the downstream flow through barricades). Therefore, pedestrians wait at their position, stay in their comfort zone and do not push each other. Thus, even at intermediate local density, pedestrians have such low speeds. This violates the general assumption that pedestrians change their speed only at the shockwave boundary. The movement of pedestrians at upstream is governed by local density and information of congestion status ahead, whereas pedestrian movement at downstream is governed by factors like density, side friction and pedestrians’ willingness to compensate for the delay at bottleneck. This study is expected to have application in planning and operation of pedestrian facilities

Determination of pedestrian’s personal space in mass religious gatherings - A case study of Kumbh Mela

Personal space can be defined as the physical distance between two individuals in a social environment. It varies from person to person depending on culture and context and there are significant individual differences too. Studying personal space includes the ability to recognize the various zones of involvement and the activities, relationships, and emotions associated with each zone. This paper tries to formulate and define personal space in high density crowd situations in Kumbh Mela, one of the world’s largest mass religious gatherings. Video data of pilgrims taking part in the Panchkroshi Yatra, a religious walkathon which is a part of KumbhMela, is used for the analysis of factors affecting personal space. To identify the thresholds of personal space, walking speed of individuals, gender, presence of luggage and the number of males and females surrounding an individual have been considered. It is found that the average speed of the individual, the group size,and the gender ratio of group members have a significant effect on the personal space of an individual. Also, it is observed that the personal space follows an asymmetrical pattern rather than a symmetrical pattern

Analyzing and Predicting Low-Listenership Trends in a Large-Scale Mobile Health Program: A Preliminary Investigation

Mobile health programs are becoming an increasingly popular medium for dissemination of health information among beneficiaries in less privileged communities. Kilkari is one of the world's largest mobile health programs which delivers time sensitive audio-messages to pregnant women and new mothers. We have been collaborating with ARMMAN, a non-profit in India which operates the Kilkari program, to identify bottlenecks to improve the efficiency of the program. In particular, we provide an initial analysis of the trajectories of beneficiaries' interaction with the mHealth program and examine elements of the program that can be potentially enhanced to boost its success. We cluster the cohort into different buckets based on listenership so as to analyze listenership patterns for each group that could help boost program success. We also demonstrate preliminary results on using historical data in a time-series prediction to identify beneficiary dropouts and enable NGOs in devising timely interventions to strengthen beneficiary retention.Comment: Accepted to Data Science for Social Good Workshop, KDD 202

Relationship of serum uric acid, serum creatinine and serum cystatin C with maternal and fetal outcomes in rural Indian pregnant women

Background: Hypertensive disorders are the most common in pregnancy. Several studies showed a positive correlation between elevated maternal serum uric acid (UA), serum creatinine and adverse maternal and fetal outcomes, but only a few studies are available on serum cystatin C and maternal and fetal outcomes. The present study was undertaken to study the association of serum UA, creatinine and cystatin C with maternal and fetal outcomes.Methods: Out of 116 pregnant women 69 women had no hypertension and 47 had hypertension with or without proteinuria. Serum UA, creatinine and cystatin C was measured by modified Uricase method, modified kinetic Jaffe’s reaction and particle-enhanced immunonephelometric assay respectively. Multivariate logistic regression was performed to determine the independent effects of serum UA, creatinine and cystatin C on maternal and fetal outcomes using stata 13.1.Results: The adjusted odds ratio (OR) was 3.73 (95% CI: 1.18-11.75; P=0.024) for UA; 15.79 (95% CI: 3.04-81.94; P=0.001) for creatinine and 2.03 (95% CI: 0.70-5.87; P=0.192) for cystatin C in hypertensive disorders of pregnancy. All the three renal parameters were not significantly associated with birth weight, gestational age of delivery and mode of delivery after adjusting for the confounding factors.Conclusions: Serum creatinine and uric acid are independent risk factors for hypertensive disorders of pregnancy. High serum uric acid is associated with low birth weight and delivery by caesarian section whereas high serum creatinine with preterm delivery only before adjustment for confounding factors and not after adjustment. Serum cystatin C was not significantly associated with the maternal and fetal outcomes.

STABILITY INDICATING METHOD DEVELOPMENT AND VALIDATION FOR ESTIMATION OF DORIPENEM IN BULK AND IN SOLID DOSAGE FORM BY RP-HPLC

A robust and reliable high performance liquid chromatographic (HPLC) approach was developed and validated for the analysis of Doripenem in pharmaceutical dosage form. The method is characterised by its simplicity, selectivity, precision, and capacity to accurately determine the stability of Doripenem. The experimental setup included the use of a Hypersil BDS-C18 column (250 X 4.6 mm ID, 5 µm) as the stationary phase in a chromatographic system. The mobile phase consisted of a combination of methanol and potassium dihydrogen orthophosphate with a pH of 6.7, in a ratio of 20:80. The flow rate of the mobile phase was set at 1 ml/min. The detection of the eluents occurred at a wavelength of 290 nm. The observed retention time for Doripenem was 5.56 minutes. Doripenem underwent acid and alkali hydrolysis, oxidation, photochemical degradation, and heat degradation. The results obtained from the linear regression analysis of the calibration plot demonstrated a strong linear connection within the concentration range of 70 – 130 µg/ml, as shown by a correlation coefficient value of 0.9995. The methodology was assessed to determine its precision, accuracy, ruggedness, and robustness. The medication experiences deterioration when exposed to environments characterised by acidity, alkalinity, photochemical reactions, and thermal stress. The active medicinal component exhibited distinct retention periods for each of its degradation product peaks, indicating successful resolution. The approach's ability to successfully isolate the medication from its degradation products renders it suitable for use as a stability-indicating method

'Swim, swim and die at the beach’:family court and perpetrator induced trauma (CPIT) experiences of mothers in Brazil

Gender-based violence (GBV) and Domestic Violence (DV) are prevalentin Brazil. There are growing concerns globally regarding theweaponisation of the pseudo-concept ‘Parental Alienation’ (PA) inthe family courts against women. Additionally, a lack of understandingof mothers’ family court and health-related experiencesindicated a need to explore this topic further. A qualitative studywas conducted with thirteen mothers who are victims of DomesticViolence and have been accused of PA. Mothers reported a range ofharmful health experiences, delineated here under the conceptualframework of Court and Perpetrator Induced Trauma (CPIT). Sixthemes are presented, which encapsulate a range of harmfulactions, behaviours and circumstances (ABCs) that surround thesemothers and their responses to these ABCs. Multiple physical healthconditions were reported as associated with family court proceedings.This included maternity problems, musculoskeletal, autoimmune,and respiratory conditions and a broad range of mentalhealth implications including suicide and other trauma responses.Human rights violations, the weaponisation of ‘Parental Alienation’and inherently misogynistic and oppressive justice systems in Brazilwere also reported. Urgent measures and further research are nowneeded to investigate causal links between harm to health and thefamily courts and to strengthen human rights protection forwomen and child victims in Brazil and beyond

The contribution of childhood adversity to cortisol measures of early life stress amongst infants in rural India: findings from the early life stress sub-study of the SPRING cluster randomised controlled trial (SPRING-ELS)

Background: The majority of the world’s children live in low- and middle-income countries and face multiple obstacles to optimal wellbeing. The mechanisms by which adversities – social, cultural, psychological, environmental, economic – get ‘under the skin’ in the early days of life and become biologically embedded remain an important line of enquiry. We therefore examined the contribution of childhood adversity through pregnancy and the first year of life to hair and salivary cortisol measures of early life stress in the India SPRING home visits cluster RCT which aims to improve early childhood development. Methods: We assessed 22 adversities across four domains: socioeconomic, maternal stress, family-child relationship, and child and summed them to make a cumulative adversity score & quintiles, and four subscale scores. We cut 3 cm of hair from the posterior vertex and took three saliva samples from morning till late afternoon on each of two days (total six samples). We analysed both for cortisol concentration using ELISA techniques. We used multiple linear regression techniques to assess the relationship between cumulative adversity and log hair cortisol concentration and saliva diurnal slope and area under the curve. Results: We assessed 712 children for hair, and 752 children for saliva cortisol at 12 months of age. We found a strong positive relationship between adversity and hair cortisol; each additional adversity factor was associated with hair cortisol increases of 6.1% (95% CI 2.8, 9.4, p < 0.001) and the increase from adversity quintile one to five was 59.4%. Socioeconomic, relationship and child scales were independent predictors of hair cortisol (socioeconomic 6.4% (95% CI -0.4, 13.6); relationship 11.8% (95% CI 1.4, 23.2); child 7.9% (95% CI -0.5, 16.9). We did not find any association between any measures of adversity and either of the saliva cortisol outcomes. Discussion: This is the largest study of hair cortisol in young children, and the first in a low- and middle-income country setting. Whilst the short-term diurnal measures of cortisol did not appear to be linked with adversity, chronic exposure over several months appears to be strongly associated with cumulative adversity. These findings should spur further work to understand the specific ways in which adversity becomes biologically embedded, and how this can be tackled. They also lend support to ongoing action to tackle childhood adversity in communities around the world

Diagnostic accuracy of cyst fluid amphiregulin in pancreatic cysts

<p>Abstract</p> <p>Background</p> <p>Accurate tests to diagnose adenocarcinoma and high-grade dysplasia among mucinous pancreatic cysts are clinically needed. This study evaluated the diagnostic utility of amphiregulin (AREG) as a pancreatic cyst fluid biomarker to differentiate non-mucinous, benign mucinous, and malignant mucinous cysts.</p> <p>Methods</p> <p>A single-center retrospective study to evaluate AREG levels in pancreatic cyst fluid by ELISA from 33 patients with a histological gold standard was performed.</p> <p>Results</p> <p>Among the cyst fluid samples, the median (IQR) AREG levels for non-mucinous (n = 6), benign mucinous (n = 15), and cancerous cysts (n = 15) were 85 pg/ml (47-168), 63 pg/ml (30-847), and 986 pg/ml (417-3160), respectively. A significant difference between benign mucinous and malignant mucinous cysts was observed (<it>p </it>= 0.025). AREG levels greater than 300 pg/ml possessed a diagnostic accuracy for cancer or high-grade dysplasia of 78% (sensitivity 83%, specificity 73%).</p> <p>Conclusion</p> <p>Cyst fluid AREG levels are significantly higher in cancerous and high-grade dysplastic cysts compared to benign mucinous cysts. Thus AREG exhibits potential clinical utility in the evaluation of pancreatic cysts.</p