Gravitational-wave Detection With Matter-wave Interferometers Based On Standing Light Waves

We study the possibility of detecting gravitational-waves with matter-wave interferometers, where atom beams are split, deflected and recombined totally by standing light waves. Our calculation shows that the phase shift is dominated by terms proportional to the time derivative of the gravitational wave amplitude. Taking into account future improvements on current technologies, it is promising to build a matter-wave interferometer detector with desired sensitivity.Comment: 7 pages, 3 figures. To be published in General Relativity and Gravitatio

The MeerKAT Fornax Survey

We present the science case and observations plan of the MeerKAT Fornax Survey, an HI and radio continuum survey of the Fornax galaxy cluster to be carried out with the SKA precursor MeerKAT. Fornax is the second most massive cluster within 20 Mpc and the largest nearby cluster in the southern hemisphere. Its low X-ray luminosity makes it representative of the environment where most galaxies live and where substantial galaxy evolution takes place. Fornax's ongoing growth makes it an excellent laboratory for studying the assembly of clusters, the physics of gas accretion and stripping in galaxies falling in the cluster, and the connection between these processes and the neutral medium in the cosmic web. We will observe a region of 12 deg2 reaching a projected distance of 1.5 Mpc from the cluster centre. This will cover a wide range of environment density out to the outskirts of the cluster, where gas-rich in-falling groups are found. We will: study the HI morphology of resolved galaxies down to a column density of a few times 1e+19 cm−2 at a resolution of 1 kpc; measure the slope of the HI mass function down to M(HI) 5e+5 M(sun); and attempt to detect HI in the cosmic web reaching a column density of 1e+18 cm−2 at a resolution of 10 kpc

Structure, mass and stability of galactic disks

In this review I concentrate on three areas related to structure of disks in spiral galaxies. First I will review the work on structure, kinematics and dynamics of stellar disks. Next I will review the progress in the area of flaring of HI layers. These subjects are relevant for the presence of dark matter and lead to the conclusion that disk are in general not `maximal', have lower M/L ratios than previously suspected and are locally stable w.r.t. Toomre's Q criterion for local stability. I will end with a few words on `truncations' in stellar disks.Comment: Invited review at "Galaxies and their Masks" for Ken Freeman's 70-th birthday, Sossusvlei, Namibia, April 2010. A version with high-res. figures is available at http://www.astro.rug.nl/~vdkruit/jea3/homepage/Namibiachapter.pd

Comparative interactomics analysis of different ALS-associated proteins identifies converging molecular pathways

Amyotrophic lateral sclerosis (ALS) is a devastating neurological disease with no effective treatment available. An increasing number of genetic causes of ALS are being identified, but how these genetic defects lead to motor neuron degeneration and to which extent they affect common cellular pathways remains incompletely understood. To address these questions, we performed an interactomic analysis to identify binding partners of wild-type (WT) and ALS-associated mutant versions of ATXN2, C9orf72, FUS, OPTN, TDP-43 and UBQLN2 in neuronal cells. This analysis identified several known but also many novel binding partners of these proteins. Interactomes of WT and mutant ALS proteins were very similar except for OPTN and UBQLN2, in which mutations caused loss or gain of protein interactions. Several of the identified interactomes showed a high degree of overlap: shared binding partners of ATXN2, FUS and TDP-43 had roles in RNA metabolism; OPTN- and UBQLN2-interacting proteins were related to protein degradation and protein transport, and C9orf72 interactors function in mitochondria. To conf

Candidate CSPG4 mutations and induced pluripotent stem cell modeling implicate oligodendrocyte progenitor cell dysfunction in familial schizophrenia

Schizophrenia is highly heritable, yet its underlying pathophysiology remains largely unknown. Among the most well-replicated findings in neurobiological studies of schizophrenia are deficits in myelination and white matter integrity; however, direct etiological genetic and cellular evidence has thus far been lacking. Here, we implement a family-based approach for genetic discovery in schizophrenia combined with functional analysis using induced pluripotent stem cells (iPSCs). We observed familial segregation of two rare missense mutations in Chondroitin Sulfate Proteoglycan 4 (CSPG4) (c.391G > A [p.A131T], MAF 7.79 × 10−5 and c.2702T > G [p.V901G], MAF 2.51 × 10−3). The CSPG4A131T mutation was absent from the Swedish Schizophrenia Exome Sequencing Study (2536 cases, 2543 controls), while the CSPG4V901G mutation was nominally enriched in cases (11 cases vs. 3 controls, P = 0.026, OR 3.77, 95% CI 1.05–13.52). CSPG4/NG2 is a hallmark protein of oligodendrocyte progenitor cells (OPCs). iPSC-derived OPCs from CSPG4A131T mutation carriers exhibited abnormal post-translational processing (P = 0.029), subcellular localization of mutant NG2 (P = 0.007), as well as aberrant cellular morphology (P = 3.0 × 10−8), viability (P = 8.9 × 10−7), and myelination potential (P = 0.038). Moreover, transfection of healthy non-carrier sibling OPCs confirmed a pathogenic effect on cell survival of both the CSPG4A131T (P = 0.006) and CSPG4V901G (P = 3.4 × 10−4) mutations. Finally, in vivo diffusion tensor imaging of CSPG4A131T mutation carriers demonstrated a reduction of brain white matter integrity compared to unaffected sibling and matched general population controls (P = 2.2 × 10−5). Together, our findings provide a convergence of genetic and functional evidence to implicate OPC dysfunction as a candidate pathophysiological mechanism of familial schizophrenia

GASP XXVI. HI gas in jellyfish galaxies : the case of JO201 and JO206

Please read abstract in the article.European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme grant agreement no. 679627 and no.833824, project name FORNAX and GASP, respectively. We acknowledge funding from the agreement ASI-INAF n.2017-14-H.0, as well as from the INAF main-stream funding programme. M. R’s research is supported by the SARAO HCD programme via the "New Scientific Frontiers with Precision Radio Interferometry" research group grant. M. R. acknowledges support from the Italian Ministry of Foreign A airs and International Cooperation (MAECI Grant Number ZA18GR02) and the South African Department of Science and Technology’s National Research Foundation (DST-NRF Grant Number 113121) as part of the ISARP RADIOSKY2020 Joint Research Scheme. B. V. and M. G. also acknowledge the Italian PRIN-Miur 2017 (PI A. Cimatti). Y. J. acknowledges financial support from CONICYT PAI (Concurso Nacional de Insercion en la Academia 2017), No. 79170132 and FONDECYT Iniciación 2018 No. 11180558. M. V. acknowledges support by the Netherlands Foundation for Scientific Research (NWO) through VICI grant 016.130.338.http://www.aanda.orgam2020Physic

The MeerKAT Fornax Survey. I. Survey description and first evidence of ram pressure in the Fornax galaxy cluster

The MeerKAT Fornax Survey maps the distribution and kinematics of atomic neutral hydrogen gas (HI) in the nearby Fornax galaxy cluster using the MeerKAT telescope. The 12 deg^2 survey footprint covers the central region of the cluster out to ~ Rvir and stretches out to ~ 2 Rvir towards south west to include the NGC 1316 galaxy group. The HI column density sensitivity (3 sigma over 25 km/s) ranges from 5e+19/cm^2 at a resolution of ~ 10" (~ 1 kpc at the 20 Mpc distance of Fornax) down to ~ 1e+18/cm^2 at ~ 1' (~ 6 kpc), and slightly below this level at the lowest resolution of ~ 100" (~ 10 kpc). The HI mass sensitivity (3 sigma over 50 km/s) is 6e+5 Msun. The HI velocity resolution is 1.4 km/s. In this paper we describe the survey design and HI data processing, and we present a sample of six galaxies with long, one-sided, star-less HI tails (of which only one was previously known) radially oriented within the cluster and with measurable internal velocity gradients. We argue that the joint properties of the HI tails represent the first unambiguous evidence of ram pressure shaping the distribution of HI in the Fornax cluster. The disturbed optical morphology of all host galaxies supports the idea that the tails consist of HI initially pulled out of the galaxies' stellar body by tidal forces. Ram pressure was then able to further displace the weakly bound HI and give the tails their present direction, length and velocity gradient.Comment: Astronomy & Astrophysics, accepted. Data available at the MeerKAT Fornax Survey website https://sites.google.com/inaf.it/meerkatfornaxsurve