Adaptation du Voice Handicap Index à la voix chantée

The present study is the outcome of 5 former studies aiming at adapting the V.H.I. to singers. We propose in this last version a V.H.I. valid for all types of singers, dysodic or not. The reliability, validity and internal coherence were evaluated on a population of 192 classical singers and 27 non singers. The comparison of the mean scores at the test and the retest shows that the results at the retest are significantly inferior in both the functional scale (p= 0.013) and the global score (p= 0.006). The test/re-test stability is good (ICC: Functional scale (F): 0.869, Emotional scale (E): 0.846, Physical scale (P): 0.85, Global score (G): 0.878/ Spearman's rho F: 0.855, E: 0.834, P: 0.858, G: 0.886). The internal coherence of each sub scale is good (Cronbach's alpha: > 0.80). The correlation between the 3 subscales is quite high (FvsE: 0,613 /EvsP: 0,737/ FvsP: 0,693) which means that each scale measures a specific dimension but that they are still homogeneous. The test/re-test difference between the singers and the controls are not significant but the control group has a greater variability in their answers (Levene test: F: p<0.001; P: p= 0.009; G: p= 0.02). Three variables increase the results: being a solist (F: p= 0.046; E: p= 0.002; P: p= 0.056; G: p= 0.006), being an amateur (F: p< 0.001; E: p= 0.019; P: p< 0.001; G: p= 0.001), having a vocal complaint (F, E, P et G: p< 0.001). This version of the V.H.I. is reliable, valid and adapted to the population of classical singers

A Clinical Workstation Software for Voice Quality Assessment

info:eu-repo/semantics/publishe

Yeast at the forefront of research on ageing and age-related diseases

Ageing is a complex and multifactorial process driven by genetic, environmental and stochastic factors that lead to the progressive decline of biological systems. Mechanisms of ageing have been extensively investigated in various model organisms and systems generating fundamental advances. Notably, studies on yeast ageing models have made numerous and relevant contributions to the progress in the field. Different longevity factors and pathways identified in yeast have then been shown to regulate molecular ageing in invertebrate and mammalian models. Currently the best candidates for anti-ageing drugs such as spermidine and resveratrol or anti-ageing interventions such as caloric restriction were first identified and explored in yeast. Yeasts have also been instrumental as models to study the cellular and molecular effects of proteins associated with age-related diseases such as Parkinson's, Huntington's or Alzheimer's diseases. In this chapter, a review of the advances on ageing and age-related diseases research in yeast models will be made. Particular focus will be placed on key longevity factors, ageing hallmarks and interventions that slow ageing, both yeast-specific and those that seem to be conserved in multicellular organisms. Their impact on the pathogenesis of age-related diseases will be also discussed.(undefined