Soil Biocementation via Enzyme Induced Carbonate Precipitation (EICP) Method Employing Soybeans as a Source of Cheap Enzyme

In this work, the soil improvement technique via Enzyme Induced Carbonate Precipitation (EICP) was investigated by employing, as an alternative to expensive pure enzymes, enzymes extracted from agro-food wastes (tomato, apple, and soybean) such that the process is economically viable and fully embraces the concept of the circular economy. The feasibility of the process was evaluated by monitoring calcium carbonate precipitation in a sand sample. The effect of selected operative parameters was investigated during the injection into different grain size sand samples. The optimal operating conditions in terms of sand grain size, temperature, Urea/Calcium concentration were found. Results demonstrated the effectiveness of this alternative solution for EICP method in term of acquired material strength and the possibility to operate sand consolidation through an economically sustainable process

Understanding refugee durable solutions by international players: Does dialogue form a missing link?

This study evaluates durable solutions in relation to refugees from East Africa. It particularly focuses on the Great Lakes countries of Rwanda, Burundi, Democratic Republic of Congo and Uganda. The study is based on the conviction that these four countries have never had peaceful transfer of power which in essence has been a major contributing factor to political violence that has caused forced mass migration in the region to this day. The use of force or military suppression has been a norm since independence of these countries in the early 1960s. This suppression has continuously forced many people to flee their homes facing abuse of their human rights, dictatorship, persecution, indiscriminate arrests, ethnic wars and political violence. Based on a survey used to collect data and in-depth interviews with selected refugees from the Great Lakes region living in Cape Town, South Africa, this paper seeks to understand durable solutions through analysing the current refugee situation. It demonstrates that durable solutions can present both challenges and solutions. It also revisits the concept of durable solutions and seeks to re-evaluate whether these various solutions offer a chance for dialogue. With the aid of a legal perspective on the refugee situation in the region, the paper qualifies the concepts of dialogue as a mechanism for peace building as well as driver for voluntary repatriation.IBS

A Phase II NCCTG Study of Irinotecan and Docetaxel in Previously Treated Patients with Non-Small Cell Lung Cancer.

PURPOSE: This Phase II study was undertaken to define the efficacy and toxicity of the combination of docetaxel and irinotecan for the second-line treatment of non-small cell lung cancer (NSCLC). PATIENTS AND METHODS: Forty-six patients with measurable NSCLC who had relapsed after an initial response to chemotherapy or who had failed to respond to initial chemotherapy, received 130 mg/m2 of irinotecan IV over 90 minutes and 50 mg/m2 docetaxel IV over 60 minutes on Day 1 q3 weeks for 6 cycles. Dexamethasone and diphenhydramine pretreatment were given. Response to treatment was evaluated by response evaluation criteria in solid tumors RECIST criteria, and toxicity was graded according to the National Cancer Institute Common Toxicity Criteria (NCI CTC) version 2.0. RESULTS: The most common severe (NCI CTC Grade 3+) adverse events were neutropenia (67 percent), diarrhea (28 percent), fatigue (20 percent), nausea (17 percent), infection (15 percent), vomiting (13 percent), leucopenia (13 percent), abdominal pain (11 percent), and dyspnea (11 percent). Grade 5 toxic events were seen in 2 patients. One of these 2 cases was a possibly-treatment related event (intestinal fistula). The median number of treatment cycles received was 3. Twelve patients (26 percent) received all 6 cycles of treatment. Five patients (11 percent) had a confirmed response (complete response (CR), partial response (PR), or regression). Median follow-up for the five surviving patients is 26.5 months (range: 25.1-28.4). Forty-two patients have reported progressive disease and 41 patients have died. Median time-to-progression (TTP) and survival are 2.6 months and 7.5 months, respectively. CONCLUSION: This second-line treatment regimen of irinotecan and docetaxel in NSCLC patients has shown activity, but can not be recommended over single-agent regimens because of significant toxicity