8 research outputs found

    High performance liquid chromatographic determination of sulpiride (Dogmatil®) in urine

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    SCOPUS: ar.jinfo:eu-repo/semantics/publishe

    Separation, identification and quantitative analysis of substituted benzamides in pharmaceutical dosage forms by high pressure liquid chromatography

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    Reverse phase high pressure liquid chromatography has been used to separate, identify and analyse five closely structurally related benzamides: procainamide, sultopride, tiapride, sulpiride and metoclopramide. The influence of various parameters on the separation (solvent composition, pH, type and concentration of the anion modifying the ionic strength of the buffer) has been examined. The results of this study suggest that the separation mode is similar to an ion pair partition chromatography in which the nature of the counter-ion is essential. The method has been applied successfully to the quantitative analysis of some of the above mentioned compounds in pharmaceutical dosage forms. © 1979.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

    High performance liquid chromatographic capacity factor and partition coefficient relationship in a benzamide series

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    High performance liquid chromatography was used to establish the relationship between capacity factor (log k') and partition coefficient (log P octanol/water) in a benzamides series. The Chromatographie parameter was correlated to log P values experimentally determined by the shake-flask method and to log P calculated from Rekker's molecular fragments approach. In both cases, for the 10 molecules studied, capacity factor on partition coefficient fit very closely a regression line. The linear model was tested for another molecule in the same series. When comparing the computed values and the experimental ones, it can be concluded that HPLC is a good tool in predicting partition coefficient in this series. © 1981.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

    HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY TECHNIQUES AND APPLICATIONS

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