5 research outputs found
Continuous Digital 12-Lead ST -Segment Monitoring in Acute Myocardial Infarction
In 1787 Aloysio Luigi Galvani (1737-1798),
at that time Professor of Anatomy at the
University of Bologna, demonstrated that
the muscles of the hind limbs of a frog
manifested "electromotive phenomena." A
partly dissected frog's leg with a metal
scalpel accidentally left in contact with an
exposed nerve showed muscle contractions
whenever a nearby electrostatic
apparatus was rotated. Ensuing experiments
led him to describe a method for
stimulating tissues electrically by simply
touching a muscle or nerve with two rods
of clissimilar metals bound together, believing
that it was due to electricity generated
within the tissues. Allesandro Volta
(1745-1827), Professor of Physics at the
University of Pavia, challenged Galvani's
interpretation by denying the existence of
animal electricity, believing that the stimulation
was due to electricity generated at
the points of contact of the two metals.
Thus arose a famous scientific controversy.
To meet Volta's objection Galvani develo
ped an experiment in which muscle contraction
was induced using living tissue instead of metal rods. He showed that if a
nerve was made to touch another tissue a
two points, one injured and the other
uninjured, the muscle supplied by the
nerve would contract. This was the first
unequivocal demonstration of the existence
of electricity in living tissue and also the
first description of the current of injury.
Since then many researchers were "galvanized"
by all kinds of electrical phenomena
in various animal models, some of
these related to the heart
Performance of an automated real-time ST-segment analysis program to detect coronary occlusion and reperfusion
A Dutch MYH7 founder mutation, p.(Asn1918Lys), is associated with early onset cardiomyopathy and congenital heart defects
Background Mutations in the myosin heavy chain 7 (MYH7) gene commonly cause cardiomyopathy but are less frequently associated with congenital heart defects. Methods In th
Non-invasive prediction of reperfusion and coronary artery patency by continuous ST segment monitoring in the GUSTO-I trial
In the GUSTO-I ECG ischaemia monitoring substudy, 1067 patients underwent continuous ST segment monitoring, using vector-derived 12-lead (406 patients), 12-lead (373 patients) and 3-lead Holter (288 patients) ECG recording systems. Simultaneous angiograms at 90 or 180 min following thrombolytic therapy were performed as a part of the prospective study in 302 patients. Infarct vessel patency was established as TIMI perfusion grades 2 or 3 and occlusion as TIMI perfusion grades 0 or 1. Coronary artery patency was predicted from ST trends up to the time of angiography. Predictive values at 90 and 180 min after the start of thrombolysis were 70% and 82% for patency and 58% and 64% for occlusion, respectively. In retrospect, accuracy appeared greatest (79-100%) in patients with extensive ST segment elevation (> or = 400 microV), if both speed of ST recovery and extent of ST segment elevation were taken into account. Although the three recording systems differed considerably in signal processing, no significant difference in accuracy was demonstrated among these systems. We conclude that continuous ECG monitoring may help select high risk patients without apparent reperfusion who may benefit from additional reperfusion therapy. As ST recovery may occur early after the start of thrombolytics and accuracy of the test is related to peak ST levels, the use of on-line ECG monitoring devices on emergency wards and cardiac care units is recommended