Explicit Control of Step Timing during Split-Belt Walking

Humans have the great ability to adapt their walking to different situations imposing distinct motor demands. However, people suffering from neurological disorders often adopt asymmetric walking pattern, affecting their mobility. It has been proposed that people can adapt spatial and temporal gait features independently when exposed to new environmental conditions. For example, previous work indicates that subjects can adapt when they step (i.e., step timing) without changing where they step (i.e., step position). New environments can be recreated using a split-belt treadmill that moves their legs at different speeds. Interestingly, this independent adaptation of spatial and temporal gait features has only been observed when subjects voluntarily modify the adaptation of spatial walking features (e.g., step position). This raises the question of whether temporal gait features (e.g., step timing) can be also altered voluntarily without affecting the adaptation of spatial ones. To address this question, we contrasted the adaptation of spatial and temporal gait features when subjects walked on a split-belt treadmill under two conditions: 1) temporal feedback condition and 2) control condition. The temporal feedback group received visual feedback indicating when to step to prevent the adaptation of step timing during split-belt walking, while the control group walked without receiving any visual feedback. Kinematic and kinetic data was recorded during the entire duration of the experiment. We found that subjects in the temporal feedback group could modulate their step timing in order to maintain a stepping rhythm similar to tied walking. In addition to this, modifying subjects’ step times reduces the impact of the perturbation, and therefore reduces the spatial adaptation. Independently of the feedback, all subjects experienced the same belt speeds on the treadmill. We show that despite being exposed to the same conditions, subjects are actually able to adapt in a way that they feel less perturbed. This study shows promising result on the possibility of establishing a relationship between spatial and temporal gait features, and therefore being able to help develop rehabilitation processes. For patients who show asymmetries in only one domain, this could be particularly useful since it could allow to target specific motor outputs

Estrategias de marketing sensorial para el fortalecimiento de la imagen corporativa de la florería rosa de Guadalupe 2022

El marketing sensorial se basa en la utilización de estrategias que estimulen los sentidos y promuevan la creación de valor de una marca y sus atributos frente al cliente. En el presente estudio se persiguió el objetivo de Proponer estrategias de marketing sensorial para fortalecer la imagen corporativa de la florería Rosa de Guadalupe SAC, Monsefú, 2022. Para lograr la finalidad se elaboró una investigación de naturaleza cuantitativa de alcance descriptivo, con un diseño de contraste no experimental de alcance transversal, trabajando con una muestra de 50 clientes que realizan sus compras en la florería. Se concluyó que las estrategias de marketing sensorial son adecuadas para fortalecer la imagen corporativa de las organizaciones, dado que es una forma de crear lazos subjetivos de manera directa a través de los sentidos, lo cual le da a la empresa la posibilidad de generar relaciones mucho más duraderas que las creadas con las campañas de comunicación. Además, la organización no aplicaba estrategias de marketing sensorial, por lo que los sentidos no se aprovechaban de manera eficiente. Así se concluyó que el markerting sensorial en la organización es malo y se debe principalmente a los aromas que no pueden ser distinguidos por los clientes, el tacto influye de manera negativa pues los soportes de los arreglos causan sensación de malestar en los clientes, y por último el diseño de la tienda tanto interior como exterior, y el diseño de los arreglos son visualmente desagradables indican los encuestados.TesisGestión empresarial y emprendimient

Diseño del plan institucional de gestión ambiental (PIGA) para la institución educativa Fundación Gimnasio Pereira

Cualquier institución pública o privada, debe garantizar unas buenas condiciones ambientales para todos sus actores y su ecosistema cercano a partir de planes administrativos de gestión que consoliden todas las estrategias ambientales como parte de un sistema unificado, donde se visualicen los problemas y potencialidades internos y se creen los programas para mitigarlos, controlarlos, disminuirlos o aprovecharlos. Una institución educativa es una parte fundamental en la formación de una sociedad ambiental, la cual tiene que garantizar desde acciones concretas como sus sistemas de gestión impactan positivamente al ambiente, desarrollando estrategias de gestion de residuos sólidos, de zonas verdes, de recursos naturales e implementar procesos pedagógicos de educación ambiental que consagren estas dimensiones en una sensibilidad cultural y social en toda su comunidad educativa (priorizando en los niños y jóvenes). Teniendo en cuenta lo atenrior, la intitucion educativa Fundacion Gimnasio Pereira, a travez de sus procesos de gesntion integral contemplan la gestion ambiental como uno de sus pilares undamentales, es por ello que el presente trabajo busca la formulacion de un Plan Institucional de Gestion Ambiental (PIGA) para establecer la base al reconocimiento interno y externo como un colegio verde.Any public or private institution must guarantee good environmental conditions for all its actors and its nearby ecosystem based on administrative management plans that consolidate all environmental strategies as part of a unified system, where internal problems and potential are visualized and create programs to mitigate, control, reduce or take advantage of them. An educational institution is a fundamental part in the formation of an environmental society, which has to guarantee from concrete actions such as its management systems positively impact the environment, developing solid waste management strategies, green areas, natural resources and implement Pedagogical processes of environmental education that enshrine these dimensions in a cultural and social sensitivity throughout the educational community (prioritizing children and youth). Taking into account the above, the educational institution Fundación Gimnasio Pereira, through its integral management processes, considers environmental management as one of its fundamental pillars, which is why this work seeks to formulate an Institutional Environmental Management Plan (PIGA) to establish the foundation for internal and external recognition as a green school.PregradoAdministrador(a) AmbientalTABLA DE CONTENIDO PLAN INSTITUCIONAL DE GESTIÓN AMBIENTAL (PIGA) PARA LA INSTITUCIÓN EDUCATIVA FUNDACIÓN GIMNASIO PEREIRA. ....................... 8 INTRODUCCIÓN.......................................................................................................... 8 DEFINICIÓN DEL PROBLEMA. ................................................................................. 8 EL PROBLEMA......................................................................................................... 8 RELACIÓN CAUSA Y EFECTO............................................................................... 8 DESCRIPCIÓN DEL PROBLEMA............................................................................ 9 JUSTIFICACIÓN......................................................................................................... 10 OBJETIVOS. ............................................................................................................... 13 OBJETIVO GENERAL:........................................................................................... 13 OBJETIVOS ESPECÍFICOS:................................................................................... 13 MARCO REFERENCIA. ............................................................................................. 13 MARCO CONTEXTUAL FUNDACION GIMNASIO PEREIRA............................ 13 MARCO CONCEPTUAL......................................................................................... 16 MARCO NORMATIVO:.......................................................................................... 20 MARCO METODOLÓGICO:...................................................................................... 22 RESULTADOS .............................................................................................................. 26 RESULTADOS OBJETIVO N°1: DIAGNÓSTICO AMBIENTAL FUNDACIÓN GIMNASIO PEREIRA................................................................................................. 26 INTRODUCCIÓN AL DIAGNÓSTICO AMBIENTAL. .......................................... 26 ZONIFICACIÓN AMBIENTAL .............................................................................. 27 DIMENSIONES AMBIENTALES........................................................................... 28 RESIDUOS SÓLIDOS................................................................................................. 28 ZONAS VERDES..................................................................................................... 33 RECURSOS NATURALES...................................................................................... 37 EDUCACIÓN AMBIENTAL. .................................................................................. 42 PROBLEMAS Y POTENCIALIDADES AMBIENTALES...................................... 54 RESULTADOS OBJETIVO N°2: ANÁLISIS DEL DIAGNÓSTICO. ....................... 57 EVALUACIÓN DE IMPACTO AMBIENTAL Y JERARQUIZACIÓN DE PROBLEMAS Y POTENCIALIDADES...................................................................... 57 IDENTIFICACION DEL PERFIL DE CAPACIDAD INTERNA (PCI) Y EL PERFIL DE OPORTUNIDAD Y AMENAZA DEL MEDIO (POAM). ..................................... 60 PERFIL DE CAPACIDAD INTERNA (PCI):........................................................... 60 PERFIL DE OPORTUNIDADES Y AMENAZAS DEL MEDIO (POAM): ............. 61 ANÁLISIS E IDENTIFICACIÓN DE ESTRATEGIAS DE GESTIÓN AMBIENTAL.62 RESULTADOS OBJETIVO N°3: FORMULACIÓN DEL PLAN INSTITUCIONAL DE GESTIÓN AMBIENTAL (PIGA) DE LA FUNDACIÓN GIMNASIO PEREIRA. ........................................................................................................................................ 62 POLÍTICA AMBIENTAL............................................................................................ 62 DESCRIPCIÓN DEL PIGA...................................................................................... 62 MISIÓN AMBIENTAL............................................................................................ 62 VISIÓN AMBIENTAL............................................................................................. 63 OBJETIVO GENERAL............................................................................................ 63 OBJETIVOS ESPECÍFICOS. ................................................................................... 63 PLAN INSTITUCIONAL DE GESTIÓN AMBIENTAL. ........................................... 63 GUÍA DE LOS PROGRAMAS DE GESTIÓN AMBIENTAL INTERNA. .................. 63 PROGRAMA (#1) PARA LA GESTIÓN INTEGRAL DE RESIDUOS SÓLIDOS INTERNA. ............................................................................................................... 65 PROGRAMA (#2) PARA LA GESTIÓN Y APROVECHAMIENTO DE RESIDUOS SÓLIDOS. ................................................................................................................ 67 PROGRAMA (#3) PARA LA GESTIÓN INTEGRAL DE LAS ZONAS VERDES. 69 PROGRAMA (#4) PARA LA CREACIÓN DE CAMPAÑAS VISUALES DE EDUCACIÓN AMBIENTAL. .................................................................................. 71 PROGRAMA (#5) PARA LA ELABORACIÓN Y ACTUALIZACIÓN DEL PRAE 2022.......................................... 73 PROGRAMA (#6) PARA EL USO Y AHORRO EFICIENTE DE LOS RECURSOS NATURALES AGUA Y ENERGÍA......................................................................... 75 CONCLUSIONES Y RECOMENDACIONES GENERALES.................................... 77 BIBLIOGRAFÍA ........................................................................................................... 78 ANEXOS ........................................................................................................................ 8

Applicability of a flood forecasting system for Nebraska watersheds

Accurate and timely flood prediction can reduce the risk of flooding, bolster preparedness, and help build resilience. In this study, we have developed a flood forecasting system prototype and checked its potential for carrying out operational flood forecasting in the state of Nebraska. This system builds upon some of the core components of the Iowa Flood Information System (IFIS), which is a state-of-the-art platform widely recognized around the world. We implemented our platform on a pilot basin in Nebraska (Elkhorn River basin) by installing eight stream sensors and setting up the hydrologic model component of IFIS, i.e., the Hillslope Link Model (HLM). Due to their importance in the Midwest, we particularly emphasized the snow processes and developed an improved HLM model that can account for different aspects of snow (rain-snow-partitioning, snowmelt, and snow accumulation) through simple parameterizations. Results show that the more thorough treatment of snow processes in the hydrologic model, as proposed herein, leads to better flood peak simulations. In this paper, we discuss different steps involved in developing the flood forecasting system prototype, along with the associated challenges and opportunities. Supplementary materials attached below

Generalization of the post-collision interaction effect from gas-phase to solid-state systems demonstrated in thiophene and its polymers

We demonstrate experimentally and theoretically the presence of the post-collision interaction (PCI) effect in sulfur KL2,3L2,3 Auger electron spectra measured in the gas-phase thiophene and in solid-state organic polymers: polythiophene (PT) and poly(3-hexylthiophene-2,5-diyl), commonly known as P3HT. PCI manifests itself through a distortion and a blueshift of the normal Auger S KL2,3L2,3 spectrum when S 1s ionization occurs close to the ionization threshold. Our investigation shows that the PCI-induced shift of the Auger spectra is stronger in the solid-state polymers than in the gas-phase organic molecule. Theoretical modeling within the framework of the eikonal approximation provides good agreement with the experimental observations. In a solid medium, two effects influence the interaction between the photoelectron and the Auger electron. In detail, stronger PCI in the polymers is attributed to the photoelectron scattering in the solid, which overcompensates the polarization screening of electron charges which causes a reduction of the interaction. Our paper demonstrates the general nature of the PCI effect occurring in different media

X-ray induced ultrafast charge transfer in thiophene-based conjugated polymers controlled by core-hole clock spectroscopy

We explore ultrafast charge transfer (CT) resonantly induced by hard X-ray radiation in organic thiophene-based polymers at the sulfur K-edge. A combination of core-hole clock spectroscopy with real-time propagation time-dependent density functional theory simulations gives an insight into the electron dynamics underlying the CT process. Our method provides control over CT by a selective excitation of a specific resonance in the sulfur atom with monochromatic X-ray radiation. Our combined experimental and theoretical investigation establishes that the dominant mechanism of CT in polymer powders and films consists of electron delocalisation along the polymer chain occurring on the low-femtosecond time scale

X-ray induced ultrafast charge transfer in thiophene-based conjugated polymers controlled by core-hole clock spectroscopy

We explore ultrafast charge transfer (CT) resonantly induced by hard X-ray radiation in organicthiophene-based polymers at the sulfur K-edge. A combination of core-hole clock spectroscopy withreal-time propagation time-dependent density functional theory simulations gives an insight into theelectron dynamics underlying the CT process. Our method provides control over CT by a selectiveexcitation of a specific resonance in the sulfur atom with monochromatic X-ray radiation. Our combinedexperimental and theoretical investigation establishes that the dominant mechanism of CT in polymerpowders and films consists of electron delocalisation along the polymer chain occurring on the low-femtosecond time scale

Ultrafast Nuclear Dynamics in Double-Core Ionized Water Molecules

Double-core-hole (DCH) states in isolated water and heavy water molecules, resulting from the sequential absorption of two x-ray photons, have been investigated. A comparison of the subsequent Auger emission spectra from the two isotopes provides direct evidence of ultrafast nuclear motion during the 1.5 fs lifetime of these DCH states. Our numerical results align well with the experimental data, providing for various DCH states an in-depth study of the dynamics responsible of the observed isotope effect

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London

Epigenetic control of epithelial-mesenchymal transition

El proceso de transición epitelio-mesénquima (TEM) permite que una célula epitelial, de manera temporal, adquiera un fenotipo mesenquimal como respuesta a un estímulo interno o externo. Este proceso se caracteriza por la activación y represión de genes involucrados en diferentes vías de señalización asociadas con migración, invasión, apoptosis, entre otros. En este proceso, la epigenética cumple un papel fundamental, pues comprende cuatro mecanismos: metilación de ADN, modificación covalente de histonas, ARN no codificantes (ARNnc) y complejos remodeladores de la cromatina, que regulan la expresión de un gen sin alterar su secuencia. En esta revisión de tema los autores describen los principales mecanismos epigenéticos involucrados en la regulación de la expresión de genes que se activan y reprimen a lo largo del proceso TEM.Artículo completo1-22The mesenchymal epithelial transition (MET) process allows a temporary epithelial cell to acquire a mesenchymal phenotype in response to an internal or external stimulus. This process is characterized by the activation and repression of genes involved in different signaling pathways associated with migration, invasion and apoptosis, among others. In this process epigenetics plays a fundamental role. Epigenetics comprises four mechanisms: DNA methylation, covalent modification of histones, noncoding RNAs (RNACs) and chromatin remodeling complexes, which regulate the expression of a gene without altering its sequence. In this topic review, the authors describe the main epigenetic mechanisms involved in the regulation of the expression of genes that are activated and repressed throughout the TEM process