First radiative shock experiments on the SG-II laser

We report on the design and first results from experiments looking at the formation of radiative shocks on the Shenguang-II (SG-II) laser at the Shanghai Institute of Optics and Fine Mechanics in China. Laser-heating of a two-layer CH/CH-Br foil drives a $\sim$40 km/s shock inside a gas-cell filled with argon at an initial pressure of 1 bar. The use of gas-cell targets with large (several mm) lateral and axial extent allows the shock to propagate freely without any wall interactions, and permits a large field of view to image single and colliding counter-propagating shocks with time resolved, point-projection X-ray backlighting ($\sim20$ $\mu$m source size, 4.3 keV photon energy). Single shocks were imaged up to 100 ns after the onset of the laser drive allowing to probe the growth of spatial non-uniformities in the shock apex. These results are compared with experiments looking at counter-propagating shocks, showing a symmetric drive which leads to a collision and stagnation from $\sim$40 ns onward. We present a preliminary comparison with numerical simulations with the radiation hydrodynamics code ARWEN, which provides expected plasma parameters for the design of future experiments in this facility

Very Large-Scale Neighborhood Search: Overview and Case Studies on Coloring Problems

Two key issues in local search algorithms are the definition of a neighborhood and the way to examine it. In this chapter we consider techniques for examining very large neighborhoods, in particular, ways for exactly searching them. We first illustrate such techniques using three paradigmatic examples. In the largest part of the chapter, we focus on the development and experimental study of very largescale neighborhood search algorithms for two coloring problems. The first example concerns the well-known (vertex) graph coloring problem. Despite initial promising results on the use of very large-scale neighborhoods, our final conclusion was negative: the usage of the proposed very large-scale neighborhoods did not help to improve the performance of effective stochastic local search algorithms. The second example, the graph set T-coloring problem, yielded more positive results. In this case, a very large-scale neighborhood that was specially tailored for this problem and that can be efficiently searched, resulted to be an essential component of a new state-of-the-art algorithm for various instance classes

Serious Asthma Events with Fluticasone plus Salmeterol versus Fluticasone Alone

BACKGROUND: The safe and appropriate use of long-acting beta-agonists (LABAs) for the treatment of asthma has been widely debated. In two large clinical trials, investigators found a potential risk of serious asthma-related events associated with LABAs. This study was designed to evaluate the risk of administering the LABA salmeterol in combination with an inhaled glucocorticoid, fluticasone propionate. METHODS: In this multicenter, randomized, double-blind trial, adolescent and adult patients (age, ≥12 years) with persistent asthma were assigned to receive either fluticasone with salmeterol or fluticasone alone for 26 weeks. All the patients had a history of a severe asthma exacerbation in the year before randomization but not during the previous month. Patients were excluded from the trial if they had a history of life-threatening or unstable asthma. The primary safety end point was the first serious asthma-related event (death, endotracheal intubation, or hospitalization). Noninferiority of fluticasone-salmeterol to fluticasone alone was defined as an upper boundary of the 95% confidence interval for the risk of the primary safety end point of less than 2.0. The efficacy end point was the first severe asthma exacerbation. RESULTS: Of 11,679 patients who were enrolled, 67 had 74 serious asthma-related events, with 36 events in 34 patients in the fluticasone-salmeterol group and 38 events in 33 patients in the fluticasone-only group. The hazard ratio for a serious asthma-related event in the fluticasone-salmeterol group was 1.03 (95% confidence interval [CI], 0.64 to 1.66), and noninferiority was achieved (P=0.003). There were no asthma-related deaths; 2 patients in the fluticasone-only group underwent asthma-related intubation. The risk of a severe asthma exacerbation was 21% lower in the fluticasone-salmeterol group than in the fluticasone-only group (hazard ratio, 0.79; 95% CI, 0.70 to 0.89), with at least one severe asthma exacerbation occurring in 480 of 5834 patients (8%) in the fluticasone-salmeterol group, as compared with 597 of 5845 patients (10%) in the fluticasone-only group (P<0.001). CONCLUSIONS: Patients who received salmeterol in a fixed-dose combination with fluticasone did not have a significantly higher risk of serious asthma-related events than did those who received fluticasone alone. Patients receiving fluticasone-salmeterol had fewer severe asthma exacerbations than did those in the fluticasone-only group