Inverse QSAR approach and Molecular docking studies to design novel methoxy substituted Chalcones and their Computational Anticancer activity evaluation

Abstract Quantitative structure activity-relationship (QSAR

Preparation and evaluation of modified herbal “Kumkum Powder” to reduce allergic reactions

Sindoor is the mark of a married women in Hinduism. Along the parting-line of a woman's hair (also called mang in Hindi or simandarekha in Sanskrit) or as a dot on the forehead. While in Hinduism, sindoor is the sign of married women. Single women use bindis in a variety of colours for special events, but they do not use sindoor in their hairline parting. Sindoor is the sign of married women in hinduism. A wide prevalence of socio-religious practices in the Asian subcontinent develops multiple skin diseases which may missed by dermatologist because of lack of awareness.So there is need to develop natural products. ‘Kumkum’ application can result in pigmented contact dermatitis and lichen planus pigmentosus. Sticker ‘bindis’ and ‘alta’ induce contact leukoderma. Irritant and allergic contact dermatitis occurs due to synthetic dyes. Synthetically prepared sindoor unsafe levels of lead which may cause irritation to the skin herbal sindoor has active natural pigments which deliver intense colour that does not that find fade as the day wear on. The herbal sindoor  stays for long period without any irritation