Cellulose based biopolymer nanoscaffold: A possible biomedical applications

In this work, a combination of cellulose nanofiber (CNF), coffee beans powder (CBP), and reduced graphene oxide (rGO) are used to design a nanowound dressing sheet (Nano-WDS), by vacuum pressure, for their sustained application in wound healing. Nano-WDS was analysed for its mechanical, antimicrobial, biocompatibility, etc., The Nano-WDS had favourable results of the tensile strength (12.85 ± 0.10 MPa), elongation at break (09.45 ± 0.28 %), water absorption (31.14 ± 0.04 %), and thickness (00.76 ± 0.02 mm). The biocompatibility study of Nano-WDS was analysed using human keratinocyte cell line (HaCaT), which showed excellent cell growth. The antibacterial activity was reflected in the Nano-WDS against the E.coli and S.aureus bacteria. Cellulose comprises the glucose unit and reduced graphene oxides are combined to create macromolecular interaction. The surface activity of cellulose-formed nanowound dressing sheet demonstrates a wound tissue engineering application. Based on the result of the study was proved suitable for bioactive wound dressing applications. The research proves that these Nano-WDS could be successfully used for the production of wound healing materials. © 2023 Elsevier B.V.The award of TUBITAK 2232-International Fellowship for Outstanding Researcher (Project No: 118C350) to Dr. Rethinam Senthil is gratefully acknowledged.Türkiye Bilimsel ve Teknolojik Araştırma Kurumu, TÜBİTAK: 118C35