Inter-network regions of the Sun at millimetre wavelengths

The continuum intensity at wavelengths around 1 mm provides an excellent way to probe the solar chromosphere. Future high-resolution millimetre arrays, such as the Atacama Large Millimeter Array (ALMA), will thus produce valuable input for the ongoing controversy on the thermal structure and the dynamics of this layer. Synthetic brightness temperature maps are calculated on basis of three-dimensional radiation (magneto-)hydrodynamic (MHD) simulations. While the millimetre continuum at 0.3mm originates mainly from the upper photosphere, the longer wavelengths considered here map the low and middle chromosphere. The effective formation height increases generally with wavelength and also from disk-centre towards the solar limb. The average intensity contribution functions are usually rather broad and in some cases they are even double-peaked as there are contributions from hot shock waves and cool post-shock regions in the model chromosphere. Taking into account the deviations from ionisation equilibrium for hydrogen gives a less strong variation of the electron density and with it of the optical depth. The result is a narrower formation height range. The average brightness temperature increases with wavelength and towards the limb. The relative contrast depends on wavelength in the same way as the average intensity but decreases towards the limb. The dependence of the brightness temperature distribution on wavelength and disk-position can be explained with the differences in formation height and the variation of temperature fluctuations with height in the model atmospheres.Comment: 15 pages, 10 figures, accepted for publication in A&A (15.05.07

The solar chromosphere at high resolution with IBIS. II. Acoustic shocks in the quiet internetwork and the role of magnetic fields

(Abridged) Aims: We characterize the dynamics of the quiet inter-network chromosphere by studying the occurrence of acoustic shocks and their relation with the concomitant photospheric structure and dynamics. Methods: We analyze a comprehensive data set that includes high resolution chromospheric and photospheric spectra obtained with the IBIS imaging spectrometer in two quiet-Sun regions. This is complemented by high-resolution sequences of MDI magnetograms of the same targets. From the chromospheric spectra we identify the spatio-temporal occurrence of the acoustic shocks. We compare it with the photospheric dynamics by means of both Fourier and wavelet analysis, and study the influence of magnetic structures. Results: Mid-chromospheric shocks occur as a response to underlying powerful photospheric motions at periodicities nearing the acoustic cut-off, consistent with 1-D hydrodynamical modeling. However, their spatial distribution within the supergranular cells is highly dependent on the local magnetic topology, both at the network and internetwork scale. Large portions of the internetwork regions undergo very few shocks, as "shadowed" by the horizontal component of the magnetic field. The latter is betrayed by the presence of chromospheric fibrils, observed in the core of the CaII line as slanted structures with distinct dynamical properties. The shadow mechanism appears to operate also on the very small scales of inter-network magnetic elements, and provides for a very pervasive influence of the magnetic field even in the quietest region analyzed.Comment: 18 pages, 16 figures (includes 1 Appendix). Accepted by A&A (16 October 2008). Minor changes from v1 after referee's comments. Higher quality figures available at http://www.arcetri.astro.it/~gcauzzi/papers_astroph/ibis.shocks.accepted.pd

Optimisation of biomass, exopolysaccharide and intracellular polysaccharide production from the mycelium of an identified Ganoderma lucidum strain QRS 5120 using response surface methodology

Wild-cultivated medicinal mushroom Ganoderma lucidum was morphologically identified and sequenced using phylogenetic software. In submerged-liquid fermentation (SLF), biomass, exopolysaccharide (EPS) and intracellular polysaccharide (IPS) production of the identified G. lucidum was optimised based on initial pH, starting glucose concentration and agitation rate parameters using response surface methodology (RSM). Molecularly, the G. lucidum strain QRS 5120 generated 637 base pairs, which was commensurate with related Ganoderma species. In RSM, by applying central composite design (CCD), a polynomial model was fitted to the experimental data and was found to be significant in all parameters investigated. The strongest effect (p lt 0.0001) was observed for initial pH for biomass, EPS and IPS production, while agitation showed a significant value (p lt 0.005) for biomass. By applying the optimized conditions, the model was validated and generated 5.12 g/L of biomass (initial pH 4.01, 32.09 g/L of glucose and 102 rpm), 2.49 g/L EPS (initial pH 4, 24.25 g/L of glucose and 110 rpm) and 1.52 g/L of IPS (and initial pH 4, 40.43 g/L of glucose, 103 rpm) in 500 mL shake flask fermentation. The optimized parameters can be upscaled for efficient biomass, EPS and IPS production using G. lucidum

Experimental analysis of longitudinal shear between the web and flanges of T-beams made of fibre-reinforced concrete

[EN] The longitudinal shear between the web and flanges of T-beams is an Ultimate Limit State contemplated by technical codes. For this reason, the longitudinal shear must be compared with the longitudinal shear resistance of the flange. Longitudinal shear strength can be increased by including steel fibres in the concrete mass. This article shows the experimental results of 13 T-beams mounted on two supports subjected to two central loads. Four of these beams were made with conventional concrete and nine with fibre-reinforced concrete. The direct instrumentation results are discussed and the failure process is described. Longitudinal shear cracking load is studied on the basis of both a theoretical approach and experimental results. An analysis is performed to evaluate each specimen's longitudinal shear, not only in the ultimate state, but also throughout the loading process evolution, based on load and strain records. This process involves determining each beam's effective width. The experimental data confirm an increase in longitudinal shear strength caused by adding steel fibres to concrete.Pereiro-Barceló, J.; López-Juárez, JA.; Ivorra Chorro, S.; Bonet Senach, JL. (2019). Experimental analysis of longitudinal shear between the web and flanges of T-beams made of fibre-reinforced concrete. Engineering Structures. 196:23-42. https://doi.org/10.1016/j.engstruct.2019.109280S234219

Residual capacity assessment of reinforced concrete D-Regions affected by corrosion

Important note: The present paper work was sent to Construction and Building Materials on 15 April 2020 (it is currently under review).The repair and rehabilitation of Reinforced Concrete (RC) structures affected by the corrosion of their reinforcement is a complex task. The estimation of the residual structural capacity of corroded RC structures is becoming a crucial factor in the decision-making process of repair or demolition. Many researchers have studied the effects of reinforcement corrosion on the load capacity of RC beams (Bernoulli or B-Regions) but little attention has been paid to disturbed or D-Regions. This piece of work presents a procedure for the assessment of the residual structural capacity of D-Regions in RC members. The bond deterioration between steel and concrete, the reduction of the cross-sectional area of reinforcement, the deterioration of the concrete area of the cross-section and the softening of concrete has been taken into consideration. The accuracy of the method has been tested with experimental results which exist in relevant literature

Can information affect sensory perceptions? Evidence from a survey on Italian organic food consumers

This paper aims to investigate the influence of information on consumers’ preferences and sensory perceptions of organic food using a sample of 301 Italian organic food consumers. Consumers stated their preferences for “core organic” attributes, labels and information on food products and performed blind and informed tests on strawberry yoghurts and cookies. Data were analysed using descriptive analysis, Mann-Whitney U tests and Wilcoxon signed-rank test. Results revealed that consumers appreciate “core organic” attributes, like artisanal production and variability of sensory attributes. Comparing blind and informed tests, results showed that information affects the overall liking of products and consumers’ perception of product-specific sensory attributes. However, the influence of information on sensory perceptions depends on the product category, sensory attributes and the type of information provided

RC structures cyclic behavior simulation with a model integrating plasticity, damage, and bond-slip

Copyright © 2017 John Wiley & Sons, Ltd. The behavior of reinforced concrete structures under severe demands, as strong ground motions, is highly complex; this is mainly due to the complexity of concrete behavior and to the strong interaction between concrete and steel, with several coupled failure modes. On the other hand, given the increasing awareness and concern on the worldwide seismic risk, new developments have arisen in earthquake engineering; nonetheless, some developments are mainly based on simple analytical tools that are widely used, given their moderate computational cost. This research aims to provide a solid basis for validation and calibration of such developments by using computationally efficient continuum mechanics-based tools. Within this context, this paper presents a model for 3D simulation of cyclic behavior of RC structures. The model integrates a bond-slip model developed by one of the authors and the damage variable evolution methodology for concrete damage plastic model developed by some authors. In the integrated model, a new technique is derived for efficient 3D analysis of bond-slip of 2 or more crossing reinforcing bars in beam-column joints, slabs, footings, pile caps, and other similar members. The analysis is performed by implementing the bond-slip model in a user element subroutine of Abaqus and the damage variable evolution methodology in the original concrete damage plastic model in the package. Two laboratory experiments consisting of a column and a frame subjected to cyclic displacements up to failure are simulated with the proposed formulation.Postprint (author's final draft

The angular-momentum flux in the solar wind observed during Solar Orbiter's first orbit

Aims: We present the first measurements of the angular-momentum flux in the solar wind recorded by the Solar Orbiter spacecraft. Our aim is to validate these measurements to support future studies of the Sun’s angular-momentum loss. Methods: We combined 60-min averages of the proton bulk moments and the magnetic field measured by the Solar Wind Analyser (SWA) and the magnetometer (MAG) onboard Solar Orbiter. We calculated the angular-momentum flux per solid-angle element using data from the first orbit of the mission’s cruise phase in 2020. We separated the contributions from protons and from magnetic stresses to the total angular-momentum flux. Results: The angular-momentum flux varies significantly over time. The particle contribution typically dominates over the magneticfield contribution during our measurement interval. The total angular-momentum flux shows the largest variation and is typically anticorrelated with the radial solar-wind speed. We identify a compression region, potentially associated with a co-rotating interaction region or a coronal mass ejection, which leads to a significant localised increase in the angular-momentum flux, albeit without a significant increase in the angular momentum per unit mass. We repeated our analysis using the density estimate from the Radio and Plasma Waves (RPW) instrument. Using this independent method, we find a decrease in the peaks of positive angular-momentum flux, but otherwise, our results remain consistent. Conclusions: Our results largely agree with previous measurements of the solar wind’s angular-momentum flux in terms of amplitude, variability, and dependence on radial solar-wind bulk speed. Our analysis highlights the potential for more detailed future studies of the solar wind’s angular momentum and its other large-scale properties with data from Solar Orbiter. We emphasise the need for studying the radial evolution and latitudinal dependence of the angular-momentum flux in combination with data from Parker Solar Probe and other assets at heliocentric distances of 1 au and beyond

Sequential immunotherapy and targeted therapy for metastatic BRAF V600 mutated melanoma: 4-year survival and biomarkers evaluation from the phase II SECOMBIT trial

No prospective data were available prior to 2021 to inform selection between combination BRAF and MEK inhibition versus dual blockade of programmed cell death protein-1 (PD-1) and cytotoxic T lymphocyte antigen-4 (CTLA-4) as first-line treatment options for BRAFV600-mutant melanoma. SECOMBIT (NCT02631447) was a randomized, three-arm, noncomparative phase II trial in which patients were randomized to one of two sequences with immunotherapy or targeted therapy first, with a third arm in which an 8-week induction course of targeted therapy followed by a planned switch to immunotherapy was the first treatment. BRAF/MEK inhibitors were encorafenib plus binimetinib and checkpoint inhibitors ipilimumab plus nivolumab. Primary outcome of overall survival was previously reported, demonstrating improved survival with immunotherapy administered until progression and followed by BRAF/MEK inhibition. Here we report 4-year survival outcomes, confirming long-term benefit with first-line immunotherapy. We also describe preliminary results of predefined biomarkers analyses that identify a trend toward improved 4-year overall survival and total progression-free survival in patients with loss-of-function mutations affecting JAK or low baseline levels of serum interferon gamma (IFNy). These long-term survival outcomes confirm immunotherapy as the preferred first-line treatment approach for most patients with BRAFV600-mutant metastatic melanoma, and the biomarker analyses are hypothesis-generating for future investigations of predictors of durable benefit with dual checkpoint blockade and targeted therapy