Synthesis and Antibacterial Activity of Hydrazones of Isonicotinic and Salicylic Acids Based on Acetyl Derivatives of Coumarin and Benzo[g][1,3,5]Oxadiazocine

In recent decades, the efforts of many researchers in the sphere of organic chemistry, physics and pharmacol-ogy have been focused on the search for new agents with pronounced antibacterial and especially antifungal activity. This is due to the widespread increase in the resistance of many bacterial strains and fungi to antibi-otics and antifungal drugs available in medical practice. In this regard, the number of works related to the synthesis of new potential antibiotics from the most diverse class of organic derivatives, which either include known pharmacophore groups or represent a new structural class of compounds with unknown and unex-plored activity, is increasing in the scientific literature. In this work, new previously undescribed hydrazones derivatives were obtained on the basis of physiologically active isonicotinic and salicylic acid hydroxides and laboratory-available acetyl-substituted heterocycles, namely 3-acetyl-2H-chromen-2-one 3,2-acetyl-3H-benzo[f]chromen-3-one 4 and 2,6-methanobenzo[g][1,3,5]oxadiazocine 5. The obtained hydrazones structure is explicitly proved by IR and 1H, 13C NMR spectroscopy data. The synthesized six new hydrazones under-went biological screening for antibacterial and antifungal activity on strains of microorganisms, namely gram-positive bacterium Staphylococcus aureus 209P, gram-negative bacterium Pectobacterium carotovorum VKM-B1247, and yeast-like fungus Candida albicans ATCC 10231. Screening revealed three compounds with antimicrobial activity and one promising compound — (E)-2-hydroxy-N’-(1-(2-oxochroman-3-yl)ethylidene)benzohydrazide 9, which also exhibits antifungal activity along with antimicrobial activity

Performance of a fine-sampling electromagnetic calorimeter prototype in the energy range from 1 to 19 GeV

The fine-sampling electromagnetic calorimeter prototype has been experimentally tested using the 1-19 GeV/c tagged beams of negatively charged particles at the U70 accelerator at IHEP, Protvino. The energy resolution measured by electrons is Delta{E}/E=2.8%/\sqrt{E} + 1.3%. The position resolution for electrons is Delta{x}=3.1 + 15.4/sqrt{E} mm in the center of the cell. The lateral non-uniformity of the prototype energy response to electrons and MIPs has turned out to be negligible. Obtained experimental results are in a good agreement with Monte-Carlo simulations.Comment: Article is prepared for pdflatex using the class elsart. 13 pages, 9 figures in 11 PDF file

Age dynamics of higher mental functions among the employees of law enforcement agencies

The article presents the results of the research on the age dynamics of higher mental functions among the employees of law enforcement agencies. There was an assumption that the decrease in concentration of attention, visual and somatosensory gnosis and visual memory dominate in the structure of age-related changes in higher mental functions among employees of law enforcement agencies. The sample of the study was 68 soldiers aged from 19 to 41 years (mean age of the group 27 ± 4.78). The methodological complex included methods aimed to evaluate the function of gnosis (Recognition of the figures of Poppelreiter, Had's sampling, Copying of the drawing with a rotation of 180°, Posture transfer, Feeling of Ferster, Reproduction of rhythms), attention (Schulte's Tables, Bourdon's Correction Test) and memory (Memorization of two-valued numbers, the memorization of two semantic series, the test "5 figures"). It was revealed that, irrespective of age, the functional disorder of basal-frontal, "deep" structures and temporal divisions of the brain predominates in the entire sample. The structure of age-related changes is dominated by a decline in visual-spatial functions, changes in visual and somatosensory gnosis, as well as visual memory

Pathopsychological predictors of contraindications to driving for persons with mental disorders

The present article contains the research data of pathopsychological predictors of contraindications to driving for persons with mental disorders. The data of 60 outpatient charts of patients-drivers and driver candidates who underwent a psychiatric examination in order to reveal the presence or absence of contraindications to driving was analyzed and resulted in a psychiatric diagnosis setting for the first time. The analysis was conducted with considering the following parameters: the commission decision on the presence or absence of contraindications to driving; age; mental illness diagnosis; results of pathopsychological research and data on driving experience. It was revealed that the 'criticality violation' parameter was the universal pathopsychological predictor of contraindications amongst the drivers and driver candidates surveyed. At the same time, nosospecific abnormalities of mental processes have been identified that in overall affect on the making of a medical decision on the presence of contraindications to driving. Attention disorders (its instability) were significantly more frequent, whilst the patients with organic mental disorder also had criticality violations, and the patients with personality disorder were characterized by instability of emotional reactions. Additional record of pathopsychological features can significantly improve the accuracy of the ability to safe driving assessment for drivers and driver candidates, and more effectively predict the risk of an accident

The relationship of individual psychological and individual-typological characteristics in individuals with personality disorders, committed socially dangerous acts

The relationship between individual psychological and individually-typological characteristics of patients with personality disorders who committed socially dangerous acts were studied, taking into account the severity of the organic factor and the degree of their social dangerousness. 121 males were surveyed, 70 of them were diagnosed with "organic personality disorder" and 33 - personality disorder. The types of personality disorders were diagnosed. The individual variables, the ratio of processes of system activation of behavior and its inhibition, protective styles, especially coping behaviours that constitute aggression, styles of self-regulation were analyzed. It was revealed that low settings of the system activation behavior found in the group of persons with a high degree of social dangerousness, determines the formation of individual psychological treats related to the rigidity behavior, the instability of the motives, impulsivity, negative emotionality, disinhibition. During comparison of samples of individuals with medium and high degree of social dangerousness it has been discovered that self-centeredness, as a component of self-control, high levels of affective components of aggression – anger and immature defense mechanisms significantly distinguish individuals with a high degree of public danger

Peculiarities of self-regulation of extreme profile specialists

Individually-psychological characteristics were studied and profiles of the styles of self-regulation of the employees engaged in hazardous were determined. The mainly group consisted of 30 men aged 21 to 60 years, who are specialists of dangerous professions. The comparison group included 30 men from 22 to 60 years, whose professional activity was not associated with risk. The following methods were used: questionnaire "Style of self-regulation of behavior" by V. I. Morosanova; questionnaire of self-control (H. Grasmik, 1993, adaptation Bulygina V. G., Abdrazakova A. M., 2009); the questionnaire BIS/BAS, used to study the sensitivity to punishment and reward; the questionnaire formal-dynamic properties of individuality by V. M. Rusalov; the aggression questionnaire by A. Buss and M. Perry (adaptation Enikolopov S. N., Cybulski N. P., 2007); the scale of anxiety Charles D. Spielberger (State-Trait Anxiety Inventory – STAI); personal questionnaire of the G. and S. Eysenck – EPQ. It was found that specialists hazardous professions are distinguished by: a higher level of development of the regulatory flexibility and individual system of conscious self-regulation activity; higher levels of extroversion, communication activity, the total adaptability; a lower level of reactive anxiety, trait anxiety and general emotional. Moreover, impulsiveness, egocentrism, lack of restraint and physical activity in the structure of self-monitoring specialists of dangerous professions associated with high levels of affective component of aggression and incoherence of parts of the process of self-regulation. There were allocated a 3 profile of self-regulation in specialists of dangerous professions: a) a high level of self-regulation – coupled with a high intellectual and physical development, the highest level of adaptability and general activity; b) medium – rapid response to emerging changes in the situation, the successful production alternatives, greater flexibility in the process of communicating with less intellectual and physical activity; c) low – the most developed stage of self-regulation is assessment of results with low rates of formal-dynamic properties of individuality and adaptability at the same time

Psychological and psycho-vegetative technologies of diagnostics and correction the behavior of professionals working in extreme conditions (state of problem and prospective studies)

The article is devoted to promising areas of research regulatory processes (self-control) оf the professionals working in special and extreme conditions of professional activity. The actuality of creation a comprehensive compact of the selection methods, adaptation the technologies to professional tasks, methods of psychological assistance of the specialists of hazardous occupations was shown. It was done an overview of foreign studies of the features of psychological regulation and self-control in stressful situations, neurophysiological correlates of self-control and aggressive behavior. The results of trainings of the development of the capacity for self-control, increasing resistance to the negative effects of mental exhaustion, were described. There were expounded the results of domestic investigations of the association between the self-regulation of behavior and profile of reactivity among mentally healthy and ill persons. The necessity of the development of psychodiagnostic and psychological programs for specialists in the professions of risk, aimed to improve the efficiency of regulatory processes for the adaptation to the conditions of professional activity