The diffusion of international standards on managerial practices

This article presents a comprehensive framework which identifies the relevant factors that can influence the standard adoption process, along with insights for performing a qualitative perspective analysis on the possible market diffusion of a specific standard under development or under review. This article also shows an example of framework application to the ISO 22400 standard, evidencing organizational and managerial implications on the standard adoption process

The diffusion of international standards on managerial practices

This article presents a comprehensive framework which identifies the relevant factors that can influence the standard adoption process, along with insights for performing a qualitative perspective analysis on the possible market diffusion of a specific standard under development or under review. This article also shows an example of framework application to the ISO 22400 standard, evidencing organizational and managerial implications on the standard adoption process

GERMINAÇÃO DE SEMENTES DE CRAMBE SOB INFLUÊNCIA DE DIFERENTES SUBSTRATOS E FOTOPERÍODOS

Com a busca por fontes alternativas e renováveis de energia, a cultura do crambe, antes destinada basicamente à produção de forragem, destaca-se por ser uma fonte promissora de óleo para produção de biodiesel. Todavia, informações fitotecnicas para esta cultura ainda mostram-se escassas no meio científico. O presente trabalho teve por objetivo comparar freqüências germinativas de sementes de crambe sob influência de diferentes substratos e fotoperíodos. Para isso, foram executados quatro tratamentos e seis repetições, contendo cinqüenta sementes cada, em delineamento experimental inteiramente casualizado. O experimento foi conduzido em câmara de germinação modelo BOD, onde foi testada a germinação das sementes ao quarto e sétimo dia, com substratos e fotoperíodos de: T1 germtest/12 horas; T2 substrato orgânico/12 horas; T3 germtest/14 horas e T4 substrato orgânico/14 horas. Os dados obtidos foram submetidos à análise de variância e comparação de médias pelo teste de Tukey a 5% de significância. O substrato germtest apresentou melhor efeito na germinação das sementes ao 4° e 7° dia, também apresentou maior número de plântulas normais. Os fotoperíodos de 12 horas e 14 horas, não diferiram estatisticamente entre si, porém, o maior fotoperíodo demonstrou uma tendência melhor de germinação

Results of a New Passive RF Stabilizing System

The method developed at the Milan AVF Cyclotron for stabilizing the RF accelerating voltage is a passive network where the desired stabilization is achieved by a dummy resistive load connected to the Dee and driven by the RF voltage amplitude. A small amount of the power is extracted from the Dee through a capacitive coupling and feeds the plates of two tubes operating in push-pull mode

Reduced trabecular bone mineral density and cortical thickness accompanied by increased outer bone circumference in metacarpal bone of rheumatoid arthritis patients: a cross-sectional study

Introduction The objective of this study was to assess three-dimensional bone geometry and density at the epiphysis and shaft of the third meta-carpal bone of rheumatoid arthritis (RA) patients in comparison to healthy controls with the novel method of peripheral quantitative computed tomography (pQCT). Methods PQCT scans were performed in 50 female RA patients and 100 healthy female controls at the distal epiphyses and shafts of the third metacarpal bone, the radius and the tibia. Reproducibility was determined by coefficient of varia-tion. Bone densitometric and geometric parameters were compared between the two groups and correlated to disease characteristics. Results Reproducibility of different pQCT parameters was between 0.7% and 2.5%. RA patients had 12% to 19% lower trabecular bone mineral density (BMD) (P ≤ 0.001) at the distal epiphyses of radius, tibia and metacarpal bone. At the shafts of these bones RA patients had 7% to 16% thinner cortices (P ≤ 0.03). Total cross-sectional area (CSA) at the metacarpal bone shaft of pa-tients was larger (between 5% and 7%, P < 0.02), and relative cortical area was reduced by 13%. Erosiveness by Ratingen score correlated negatively with tra-becular and total BMD at the epiphyses and shaft cortical thickness of all measured bones (P < 0.04). Conclusions Reduced trabecular BMD and thinner cortices at peripheral bones, and a greater bone shaft diameter at the metacarpal bone suggest RA spe-cific bone alterations. The proposed pQCT protocol is reliable and allows measuring juxta-articular trabecular BMD and shaft geometry at the metacarpal bone

Heptacoordinate Coii complex: a new architecture for photochemical hydrogen production

The first heptacoordinate cobalt catalyst for light-driven hydrogen production in water has been synthesized and characterized. Photochemical experiments using [Ru(bpy)₃]²⁺ as photosensitizer gave a turnover number (TON) of 16300 mol H₂ (mol  cat.)⁻¹ achieved in 2 hours of irradiation with visible (475 nm) light. This promising result provides a path forward in the development of new structures to improve the efficiency of the catalysis

Preventing implant-associated infections by silver coating

Implant-associated infections (IAI) are a dreaded complication mainly caused by biofilm-forming staphylococci. Implant surfaces preventing microbial colonization would be desirable. We examined the preventive effect of a silver-coated titanium aluminium niobium (TiAlNb) alloy. The surface elicited a strong, inoculum-dependent activity against Staphylococcus (S.) epidermidis and S. aureus in an agar inhibition assay. Gamma sterilization and alcohol disinfection did not alter the effect. In a tissue cage mouse model, silver coating of TiAlNb cages prevented peri-operative infections in an inoculum-dependent manner, and led to a 100 % prevention rate after challenge with 2 x 106 CFU S. epidermidis/cage. In S. aureus infections, silver coating had only limited effect. Similarly, daptomycin or vancomycin prophylaxis alone did not prevent S. aureus infections. However, silver coating combined with daptomycin or vancomycin prophylaxis thwarted methicillin-resistant S. aureus infections in 100 % or 33%, respectively. Moreover, silver release from the surface was independent of infection and occurred rapidly after implantation. On day 2, a peak of 82 μg Ag/ml was reached in the cage fluid corresponding to almost 6 times the minimal inhibitory concentration of the staphylococci. Cytotoxicity towards leukocytes in the cage was low and temporary. Surrounding tissue did not reveal histological signs of silver toxicity. In vitro, no emergence of silver resistance was observed in several clinical strains of staphylococci upon serial subinhibitory silver exposure. In conclusion, our data demonstrate that silver-coated TiAlNb is potent for preventing IAI and thus can be considered for clinical application

Lobster eye optics for nano-satellite x-ray monitor

The Lobster eye design for a grazing incidence X-ray optics provides wide field of view of the order of many degrees, for this reason it would be a convenient approach for the construction of space X-ray monitors. In this paper, we compare previously reported measurements of prototype lobster eye X-ray optics called P-25 with computer simulations and discuss differences between the theoretical end experimentally obtained results. Usability of this prototype lobster eye and manufacturing technology for the nano-satellite mission is assessed. The specific scientific goals are proposed

Fetal Tracheal Occlusion Increases Lung Basal Cells via Increased Yap Signaling

Basal cell; Fetal tracheal occlusion; MechanotransductionCélula basal; Oclusión traqueal fetal; MecanotransducciónCèl·lula basal; Oclusió traqueal fetal; MecanotransduccióFetal endoscopic tracheal occlusion (FETO) is an emerging surgical therapy for congenital diaphragmatic hernia (CDH). Ovine and rabbit data suggested altered lung epithelial cell populations after tracheal occlusion (TO) with transcriptomic signatures implicating basal cells. To test this hypothesis, we deconvolved mRNA sequencing (mRNA-seq) data and used quantitative image analysis in fetal rabbit lung TO, which had increased basal cells and reduced ciliated cells after TO. In a fetal mouse TO model, flow cytometry showed increased basal cells, and immunohistochemistry demonstrated basal cell extension to subpleural airways. Nuclear Yap, a known regulator of basal cell fate, was increased in TO lung, and Yap ablation on the lung epithelium abrogated TO-mediated basal cell expansion. mRNA-seq of TO lung showed increased activity of downstream Yap genes. Human lung specimens with congenital and fetal tracheal occlusion had clusters of subpleural basal cells that were not present in the control. TO increases lung epithelial cell nuclear Yap, leading to basal cell expansion.Funding was obtained from NIH/NHLBI R01HL141229 (to BV)