Study of the scientific potential of a three 40 cm Telescopes Interferometer at Dome C

Recent site testing (see: http://www-luan.unice.fr/Concordiastro/indexantartic.html) has shown that Dome C in Antarctica might have a high potential for stellar interferometry if some solutions related to the surface atmospheric layer are found. A demonstrator interferometer could be envisioned in order to fully qualify the site and prepare the future development of a large array. We analyse the performances of a prototype interferometer for Dome C made with 3 telescopes of 40 cm diameter. It assumes classical Michelson recombination. The most recent atmospheric and environmental conditions measured at Dome C are considered (see K. Agabi "First whole atmosphere night-time seeing measurements at Dome C, Antarctica"). We also study the possible science reachable with such a demonstrator. Especially we evaluate that even such small aperture interferometer could allow the detection and low resolution spectroscopy of the most favourable pegaside planets.Comment: 6 pages, 5 figures, conferences SPIE, 0rlando, 200

Comparaison des qualités sensorielles de la viande et de la carcasse d’agneaux élevés au pâturage en production biologique ou conventionnelle à deux niveaux de disponibilités en herbe

Nous avons comparé les qualités sensorielles des carcasses et des viandes d’agneaux engraissés au pâturage en élevage biologique ou conventionnel (O vs. C) à deux niveaux de disponibilités en herbe (Haut H vs. Bas L). Le profil de croissance a été maintenu similaire entre les deux systèmes de production. L’expérimentation a été conduite pendant deux années avec 12 agneaux mâles castrés de race Limousine dans chaque groupe OH, OL, CH et CL chaque année. Les traitements O et C différaient par le niveau de fertilisation azotée minérale épandu sur les parcelles. Les parcelles expérimentales étaient des repousses après fauche et elles étaient conduites en pâturage tournant pour conduire à un âge moyen des agneaux à l’abattage de 5 et 6 mois dans les lots H et L respectivement. Les côtelettes O ont été moins appréciées que les côtelettes C. L’indice de rouge du muscle longissimus thoracis et lumborum après 2h d’exposition à l’air a été plus élevé chez les agneaux L que chez les agneaux H, indiquant les effets possibles d’une intensification de l’élevage biologique à travers une augmentation du chargement

AMBER/VLTI high spectral resolution observations of the Brγ\gamma emitting region in HD 98922. A compact disc wind launched from the inner disc region

We analyse the main physical parameters and the circumstellar environment of the young Herbig Be star HD 98922. We present AMBER/VLTI high spectral resolution (R =12000) interferometric observations across the Br$\gamma$ line, accompanied by UVES high-resolution spectroscopy and SINFONI-AO assisted near-infrared integral field spectroscopic data. To interpret our observations, we develop a magneto-centrifugally driven disc-wind model. Our analysis of the UVES spectrum shows that HD 98922 is a young (~5x10^5 yr) Herbig Be star (SpT=B9V), located at a distance of 440(+60-50) pc, with a mass accretion rate of ~9+/-3x10^(-7) M_sun yr^(-1). SINFONI K-band AO-assisted imaging shows a spatially resolved circumstellar disc-like region (~140 AU in diameter) with asymmetric brightness distribution. Our AMBER/VLTI UT observations indicate that the Br$\gamma$ emitting region (radius ~0.31+/-0.04 AU) is smaller than the continuum emitting region (inner dust radius ~0.7+/-0.2 AU), showing significant non-zero V-shaped differential phases (i.e. non S-shaped, as expected for a rotating disc). The value of the continuum-corrected pure Br$\gamma$ line visibility at the longest baseline (89 m) is ~0.8+/-0.1, i.e. the Br$\gamma$ emitting region is partially resolved. Our modelling suggests that the observed Br$\gamma$ line-emitting region mainly originates from a disc wind with a half opening angle of 30deg, and with a mass-loss rate of ~2x10(-7) M_sun yr^(-1). The observed V-shaped differential phases are reliably reproduced by combining a simple asymmetric continuum disc model with our Br$\gamma$ disc-wind model. The Br$\gamma$ emission of HD 98922 can be modelled with a disc wind that is able to approximately reproduce all interferometric observations if we assume that the intensity distribution of the dust continuum disc is asymmetric.Comment: Accepted for publication on Astronomy \& Astrophysics. High resolution figures published on the main journal (see Astronomy & Astrophysics: Forthcoming) or at www.researchgate.net/profile/Alessio_Caratti_o_Garatti/publication

Hypoxia promotes chemoresistance in acute lymphoblastic leukemia cell lines by modulating death signaling pathways

International audienceBackground: Several studies show that bone marrow (BM) microenvironment and hypoxia condition can promote the survival of leukemic cells and induce resistance to anti-leukemic drugs. However, the molecular mechanism for chemoresistance by hypoxia is not fully understood.Methods: In the present study, we investigated the effect of hypoxia on resistance to two therapies, methotrexate (MTX) and prednisolone (PRD), in two cell models for acute lymphoblastic leukemia (ALL). To look for an implication of hypoxia in chemoresistance, cell viability, total cell density and cell proliferation were analyzed. Survival and death signaling pathways were also screened by "reverse phase protein array" (RPPA) and western blotting experiments conducted on selected proteins to confirm the results.Results: We found that hypoxia promotes chemoresistance in both ALL cell lines. The induction of drug-resistance by hypoxia was not associated with an increase in total cell density nor an increase in cell proliferation. Using RPPA, we show that chemoresistance induced by hypoxia was mediated through an alteration of cell death signaling pathways. This protective effect of hypoxia seems to occur via a decrease in pro-apoptotic proteins and an increase in anti-apoptotic proteins. The results were confirmed by immunoblotting. Indeed, hypoxia is able to modulate the expression of anti-apoptotic proteins independently of chemotherapy while a pro-apoptotic signal induced by a chemotherapy is not modulated by hypoxia.Conclusions: Hypoxia is a factor in leukemia cell resistance and for two conventional chemotherapies modulates cell death signaling pathways without affecting total cell density or cell proliferation

What Role for Angiogenesis in Childhood Acute Lymphoblastic Leukaemia?

The role of angiogenesis in acute leukaemia has been discussed since the cloning of the gene of vascular endothelial growth factor (VEGF) from the acute myelogenous leukemia cell line (HL60) and, thereafter, when the first studies reported increased bone marrow vascularity and elevation of angiogenic cytokines in acute lymphoblastic leukaemia (ALL). VEGF and basic fibroblast growth factor (bFGF) are the major proangiogenic cytokines that have been studied, and evaluation of their prognostic impact in childhood ALL has been reported in several studies, though with controversial results. The antiangiogenic response, contributing to the angiogenic balance, has scarcely been reported. The origin of the factors, their prognostic value, and their relevance as good markers of what really happens in the bone marrow are discussed in this paper. The place of antiangiogenic drugs in ALL has to be defined in the global treatment strategy

Estimating the phase in ground-based interferometry: performance comparison between single-mode and multimode schemes

In this paper we compare the performance of multi and single-mode interferometry for the estimation of the phase of the complex visibility. We provide a theoretical description of the interferometric signal which enables to derive the phase error in presence of detector, photon and atmospheric noises, for both multi and single-mode cases. We show that, despite the loss of flux occurring when injecting the light in the single-mode component (i.e. single-mode fibers, integrated optics), the spatial filtering properties of such single-mode devices often enable higher performance than multimode concepts. In the high flux regime speckle noise dominated, single-mode interferometry is always more efficient, and its performance is significantly better when the correction provided by adaptive optics becomes poor, by a factor of 2 and more when the Strehl ratio is lower than 10%. In low light level cases (detector noise regime), multimode interferometry reaches better performance, yet the gain never exceeds 20%, which corresponds to the percentage of photon loss due to the injection in the guides. Besides, we demonstrate that single-mode interferometry is also more robust to the turbulence in both cases of fringe tracking and phase referencing, at the exception of narrow field of views (<1 arcsec).Comment: 9 pages (+ 11 online material appendices) -- 8 Figures. Accepted in A&

Interés de las biopsias de útero como método diagnóstico de la infertilidad de origen inexplicado en la perra

Las lesiones uterinas están consideradas como una de las causas principales de la infertilidad canina. Sin embargo, hasta el momento, escasas publicaciones han evaluado su verdadero impacto en la perra. En este estudio se describen los resultados histológicos de 20 perras con infertilidad de origen indeterminado a las que se les practicó una biopsia uterina por laparotomía durante el periodo de diestro, en el 75% de los casos. Se definieron 3 grupos: perras cuya gestación nunca fue confirmada (GNC), perras con interrupción de la gestación (IG) y perras con subfertilidad. En total, el 89.5% de las biopsias fueron anormales. Las patologías más frecuentemente diagnosticadas fueron la endometritis (31.5%), la HGQ (Hiperplasia Glándulo-Quística) (31.5%) y la FDG (fibrosis asociada a la degeneración de las glándulas endometriales), (21%), que pudieron encontrarse aisladas o asociadas a otras anomalías. En ninguno de los casos se aisló un agente infeccioso. Mientras que la HGQ y la FDG probablemente jueguen un papel importante en la infertilidad, las endometritis podrían ser, en ciertos casos la causa primaria, y en otros, la consecuencia de la interrupción precoz de la gestación

Revealing the inner circumstellar disk of the T Tauri star S Coronae Australis N using the VLTI

Copyright © ESO, 2012Aims. We investigate the structure of the circumstellar disk of the T Tauri star S CrA N and test whether the observations agree with the standard picture proposed for Herbig Ae stars. Methods. Our observations were carried out with the VLTI/AMBER instrument in the H and K bands with the low spectral resolution mode. For the interpretation of our near-infrared AMBER and archival mid-infrared MIDI visibilities, we employed both geometric and temperature-gradient models. Results. To characterize the disk size, we first fitted geometric models consisting of a stellar point source, a ring-shaped disk, and a halo structure to the visibilities. In the H and K bands, we measured ring-fit radii of 0.73  ± 0.03 mas (corresponding to 0.095   ±   0.018 AU for a distance of 130 pc) and 0.85   ±   0.07 mas (0.111   ±   0.026 AU), respectively. This K-band radius is approximately two times larger than the dust sublimation radius of ≈0.05 AU expected for a dust sublimation temperature of 1500 K and gray dust opacities, but approximately agrees with the prediction of models including backwarming (namely a radius of ≈0.12 AU). The derived temperature-gradient models suggest that the disk is approximately face-on consisting of two disk components with a gap between star and disk. The inner disk component has a temperature close to the dust sublimation temperature and a quite narrow intensity distribution with a radial extension from 0.11 AU to 0.14 AU. Conclusions. Both our geometric and temperature-gradient models suggest that the T Tauri star S CrA N is surrounded by a circumstellar disk that is truncated at an inner radius of ≈ 0.11 AU. The narrow extension of the inner temperature-gradient disk component implies that there is a hot inner rim.International Max Planck Research School (IMPRS) for Astronomy and Astrophysics at the Universities of Bonn and Cologn