Influence of pedaling technique on metabolic efficiency in elite cyclists

Our objective was to investigate the influence of pedaling technique on gross efficiency (GE) at various exercise intensities in twelve elite cyclists (V̇O 2max=75.7 ± 6.2 mL•kg -1•min -1). Each cyclist completed a V̇O 2max assessment, skinfold measurements, and an incremental test to determine their lactate threshold (LT) and onset of blood lactate accumulation (OBLA) values. The GE was determined during a three-phase incremental exercise test (below LT, at LT, and at OBLA). We did not find a significant relationship between pedaling technique and GE just below the LT. However, at the LT, there was a significant correlation between GE and mean torque and evenness of torque distribution (r=0.65 and r=0.66, respectively; p < 0.05). At OBLA, as the cadence frequency increased, the GE declined (r=-0.81, p < 0.05). These results suggest that exercise intensity plays an important role in the relationship between pedaling technique and GE

V39: an unusual object in the field of IC 1613

The variable star V39 in the field of IC 1613 is discussed in the light of the available photometric and new spectroscopic data. It has strong emission Balmer lines, and the observed characteristics could be explained by a W Vir pulsating star with a period of 14.341 d, located at more than 115 kpc, that is in the very outer halo of our Galaxy. It should have an apparent companion, a long period (1118d) red variable, belonging to IC 1613. The main uncertainty in this interpretation is an emission feature at 668.4 nm, which we tentatively identified as a He I line.Comment: 5 pages; accepted for publication in Astronomy & Astrophysic

On the stability of fissured slopes subject to seismic action

A set of analytical solutions achieved by the upper bound theorem of limit analysis and the pseudo-static approach is presented for the assessment of the stability of homogeneous c, ϕ slopes manifesting vertical cracks and subject to seismic action. Rotational failure mechanisms are considered for slopes with cracks of either known or unknown depth and location. A validation exercise was carried out based on numerical limit analyses and displacement-based finite-element analyses with strength reduction technique. Charts providing the stability factor for fissured slopes subject to both horizontal and vertical accelerations for any combination of c, ϕ and slope inclination are provided. The effect of the direction of the vertical acceleration on slope stability is specifically analysed. Yield seismic coefficients are also provided. When the presence of cracks within the slope can be ascertained with reasonable confidence, maps showing the zones within the slope where they have no destabilising effect are provided. Finally, Newmark's method was employed to assess the effect of cracks on earthquake induced displacements. To this end, displacement coefficients are provided in chart form as a function of the slope characteristics. Two examples of slopes subjected to known earthquakes are illustrated

A KRAB/KAP1-miRNA Cascade Regulates Erythropoiesis Through Stage-Specific Control of Mitophagy

During hematopoiesis, lineage- and stage-specific transcription factors work in concert with chromatin modifiers to direct the differentiation of all blood cells. We explored the role of KRAB-containing zinc finger proteins (KRAB-ZFPs) and their cofactor KAP1 in this process. In mice, hematopoietic-restricted deletion of Kap1 resulted in severe hypoproliferative anemia. Kap1-deleted erythroblasts failed to induce mitophagy-associated genes and retained mitochondria. This was due to persistent expression of microRNAs (miRNAs) targeting mitophagy transcripts, itself secondary to a lack of repression by stage-specific KRAB-ZFPs. The KRAB/KAP1-miRNA regulatory cascade is evolutionarily conserved, as it also controls mitophagy during human erythropoiesis. Thus, a multilayered transcription regulatory system is present, in which protein- and RNA-based repressors are superimposed in combinatorial fashion to govern the timely triggering of an important differentiation event

African Swine Fever at the Wildlife-Livestock Interface: Challenges for Management and Outbreak Response within Invasive Wild Pigs in the United States

African swine fever (ASF) causes significant morbidity and mortality in both domestic and wild suids (Sus scrofa), and disease outbreaks convey profound economic costs to impacted industries due to death loss, the cost of culling exposed/infected animals as the primary disease control measure, and trade restrictions. The co-occurrence of domestic and wild suids significantly complicates ASF management given the potential for wild populations to serve as persistent sources for spillover. We describe the unique threat of African swine fever virus (ASFV) introduction to the United States from epidemiological and ecological perspectives with a specific focus on disease management at the wild-domestic swine interface. The introduction of ASF into domestic herds would require a response focused on containment, culling, and contact tracing. However, detection of ASF among invasive wild pigs would require a far more complex and intensive response given the challenges of detection, containment, and ultimately elimination among wild populations. We describe the state of the science available to inform preparations for an ASF response among invasive wild pigs, describe knowledge gaps and the associated studies needed to fill those gaps, and call for an integrated approach for preparedness that incorporates the best available science and acknowledges sociological attributes and the policy context needed for an integrated disease response

The multiperiodicity of the γ\gamma Doradus stars HD 224945 and HD 224638 as detected from a multisite campaign

We discuss new photometric data collected on the gamma Dor variables HD 224945 and HD 224638. Multiperiodicity was detected in both stars, thanks to the clear spectral window of a multisite campaign that involved five observatories. HD 224945 shows the shortest period among the gamma Dor stars, i.e., 0.3330 d. The pulsation behaviour is very different: HD 224945 displays a set of frequencies spread over an interval much wider than that of HD 224638. We clearly found evidence for amplitude variations in the excited modes by comparing data from different years. HD 224945 and HD 224638 are among the best examples of $\gamma$ Dor stars that show multimode pulsations, which make them very interesting from an asteroseismological point of view.Comment: 8 pages (in A&A style), 3 eps figures. Accepted for A&A Main Journa

Unexpected features of branched flow through high-mobility two-dimensional electron gases

GaAs-based two-dimensional electron gases (2DEGs) show a wealth of remarkable electronic states, and serve as the basis for fast transistors, research on electrons in nanostructures, and prototypes of quantum-computing schemes. All these uses depend on the extremely low levels of disorder in GaAs 2DEGs, with low-temperature mean free paths ranging from microns to hundreds of microns. Here we study how disorder affects the spatial structure of electron transport by imaging electron flow in three different GaAs/AlGaAs 2DEGs, whose mobilities range over an order of magnitude. As expected, electrons flow along narrow branches that we find remain straight over a distance roughly proportional to the mean free path. We also observe two unanticipated phenomena in high-mobility samples. In our highest-mobility sample we observe an almost complete absence of sharp impurity or defect scattering, indicated by the complete suppression of quantum coherent interference fringes. Also, branched flow through the chaotic potential of a high-mobility sample remains stable to significant changes to the initial conditions of injected electrons.Comment: 22 pages, 4 figures, 1 tabl

Universality of the Lyapunov regime for the Loschmidt echo

The Loschmidt echo (LE) is a magnitude that measures the sensitivity of quantum dynamics to perturbations in the Hamiltonian. For a certain regime of the parameters, the LE decays exponentially with a rate given by the Lyapunov exponent of the underlying classically chaotic system. We develop a semiclassical theory, supported by numerical results in a Lorentz gas model, which allows us to establish and characterize the universality of this Lyapunov regime. In particular, the universality is evidenced by the semiclassical limit of the Fermi wavelength going to zero, the behavior for times longer than Ehrenfest time, the insensitivity with respect to the form of the perturbation and the behavior of individual (non-averaged) initial conditions. Finally, by elaborating a semiclassical approximation to the Wigner function, we are able to distinguish between classical and quantum origin for the different terms of the LE. This approach renders an understanding for the persistence of the Lyapunov regime after the Ehrenfest time, as well as a reinterpretation of our results in terms of the quantum--classical transition.Comment: 33 pages, 17 figures, uses Revtex