The relationship between top management team – outside board conflict and outside board service involvement in high-tech start-ups

Corporate governance research has extensively studied the relationship between outside board characteristics and outside board involvement. We add to this literature by investigating the extent to which interactions between outside board members and the top management team (TMT) affect the functioning of the outside board. Building on conflict theory, our study shows how conflict between TMT and outside board is an important antecedent for outside board service involvement. Specifically, drawing from a hand-collected dataset of 70 high-tech start-ups in Belgium, we find that TMT – outside board task conflict is both directly and indirectly, i.e. through TMT – outside board relationship conflict, related to outside board service involvement

Platicizer effect on network structure and hydrolytic degradation

The hydrolytic degradation of fully cured polyester-urethane networks polymerized in the presence of several weight ratios of triacetin was monitored by the residual concentration in elastically active chains obtained from modulus and equilibrium solvent swelling measurements. The presence of triacetin does not change the water uptake but induces a lower rate of degradation. Comparisons were performed with networks in which triacetin was removed before ageing, and with networks in which polyester-urethane was first polymerized and then impregnated by triacetin. Data suggest that the presence of triacetin during polymerization induces the presence of elastically inactive chains such as dangling chains, loops… the hydrolysis of which does not change the elastic properties of the network. This explanation was checked from relaxation measurements by n.m.r and d.m.a, and by the analysis of the soluble fraction generated by hydrolysis

Remodeling of Retinal Fatty Acids in an Animal Model of Diabetes: A Decrease in Long-Chain Polyunsaturated Fatty Acids Is Associated With a Decrease in Fatty Acid Elongases Elovl2 and Elovl4

OBJECTIVE: The results of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications cohort study revealed a strong association between dyslipidemia and the development of diabetic retinopathy. However, there are no experimental data on retinal fatty acid metabolism in diabetes. This study determined retinal-specific fatty acid metabolism in control and diabetic animals. RESEARCH DESIGN AND METHODS: Tissue gene and protein expression profiles were determined by quantitative RT-PCR and Western blot in control and streptozotocin-induced diabetic rats at 3-6 weeks of diabetes. Fatty acid profiles were assessed by reverse-phase high-performance liquid chromatography, and phospholipid analysis was performed by nano-electrospray ionization tandem mass spectrometry. RESULTS: We found a dramatic difference between retinal and liver elongase and desaturase profiles with high elongase and low desaturase gene expression in the retina compared with liver. Elovl4, an elongase expressed in the retina but not in the liver, showed the greatest expression level among retinal elongases, followed by Elovl2, Elovl1, and Elovl6. Importantly, early-stage diabetes induced a marked decrease in retinal expression levels of Elovl4, Elovl2, and Elovl6. Diabetes-induced downregulation of retinal elongases translated into a significant decrease in total retinal docosahexaenoic acid, as well as decreased incorporation of very-long-chain polyunsaturated fatty acids (PUFAs), particularly 32:6n3, into retinal phosphatidylcholine. This decrease in n3 PUFAs was coupled with inflammatory status in diabetic retina, reflected by an increase in gene expression of proinflammatory markers interleukin-6, vascular endothelial growth factor, and intercellular adhesion molecule-1. CONCLUSIONS: This is the first comprehensive study demonstrating diabetes-induced changes in retinal fatty acid metabolism. Normalization of retinal fatty acid levels by dietary means or/and modulating expression of elongases could represent a potential therapeutic target for diabetes-induced retinal inflammation

The rise and change of the competence strategy: reflections on twenty-five years of skills policies in the EU

The principal aim of this article is to provide a historical overview of 25 years of competence policy in the European Union, highlighting connections between past and current initiatives and outlining possible scenarios for the decade to come. The article presents the social investment turn in social policy as the critical political background against which the emergence of a competence strategy in European Union education policy should be analysed and understood. The competence strategy, it is argued, finds its roots in a renewed attention at the European Union level for harmonising educational outputs and labour market demands. While trying to produce a schematic history of the emergence and change of the competence strategy, the article does not seek to offer strict definitions of competence itself; instead, it conveys the nebulous and context-dependent nature of the concept

Electronics Development for the Cherenkov Telescope Array

Gamma-ray astronomy promises to elucidate the highest-energy particle accelerators in the Universe, and could play a key role in identifying the nature of dark matter. The Cherenkov Telescope Array (CTA), currently in the research and development stage, will study and capture gamma-rays with an order of magnitude grater sensitivity than the instruments already in place. Each telescope in the array will be equipped with dozens of camera modules each containing four TeV Array Readout with GSa/s sampling and Event Trigger (TARGET) chips. TARGET 4 has many internal settings, several of which were tested and analyzed to achieve an optimal operating range