Symbolic numerical magnitude processing is as important to arithmetic as phonological awareness is to reading

In this article, we tested, using a 1-year longitudinal design, whether symbolic numerical magnitude processing or children’s numerical representation of Arabic digits, is as important to arithmetic as phonological awareness is to reading. Children completed measures of symbolic comparison, phonological awareness, arithmetic, reading at the start of third grade and the latter two were retested at the start of fourth grade. Cross-sectional and longitudinal correlations indicated that symbolic comparison was a powerful domain-specific predictor of arithmetic and that phonological awareness was a unique predictor of reading. Crucially, the strength of these independent associations was not significantly different. This indicates that symbolic numerical magnitude processing is as important to arithmetic development as phonological awareness is to reading and suggests that symbolic numerical magnitude processing is a good candidate for screening children at risk for developing mathematical difficulties

Cross-domain associations of key cognitive correlates of early reading and early arithmetic in 5-year-olds

Disabilities in reading and arithmetic often co-occur, but (dis)abilities in reading and arithmetic have mostly been studied in isolation from each other. This study explicitly focused on the co-development of early reading and early arithmetic before primary education. The Multiple Deficit Model was used as theoretical framework (Pennington, 2006). According to this model, the overlap between early reading and early arithmetic is due to a constellation of shared and unique cognitive correlates. Therefore, we investigated whether key cognitive correlates of one academic ability also correlate with the other. Participants were 188 five-year-old kindergartners who had not yet been formally instructed in reading and arithmetic. Phonological awareness was selected as reading-specific cognitive correlate and (non)symbolic numerical magnitude processing and numeral recognition were considered as arithmetic-specific cognitive correlates. We administered a productive letter knowledge task as a proxy of early reading. Early arithmetic was assessed with simple problems such as 2 + 3 =? . Regression analyses and Bayesian hypothesis testing revealed significant correlations between early reading and early arithmetic before children start primary education. Phonological awareness predicted not only early reading but also, early arithmetic, even when controlling for early reading and arithmetic-specific cognitive correlates. Likewise, numeral recognition predicted not only early arithmetic, but also early reading, even when controlling for early arithmetic and phonological awareness. Phonological awareness and numeral recognition can be considered shared cognitive correlates of both academic domains. In contrast, non-symbolic and symbolic numerical magnitude processing skills were specifically correlated to early arithmetic, and not to early reading, indicating that they are unique to only one academic domain. In line with the Multiple Deficit Model, our data suggest that early reading and early arithmetic have a shared as well as unique underlying cognitive basis. Further unravelling what these academic abilities have in common can be of high value for detecting children at risk already before their transition to formal primary education

The Role of Cerebral Hypoperfusion in Multiple Sclerosis (ROCHIMS) Trial in Multiple Sclerosis:Insights From Negative Results

Background:Accumulating evidence indicates that mitochondrial energy failure is involved in the progressive axonal degeneration in multiple sclerosis (MS). In patients with MS, it has been shown that both levels of N-acetylaspartate (NAA), which is a marker of axonal mitochondrial energy, and cerebral blood flow (CBF) are reduced in cerebral normal appearing white matter (NAWM). The latter is likely due to the vasoconstrictive action of endothelin-1 (ET-1) produced by reactive astrocytes, which is triggered by local proinflammatory cytokines. A preliminary study in patients with MS showed that CBF could be restored to normal values after a single dose of 62.5 mg of the ET-1 antagonist bosentan. Objective:To investigate whether restoring CBF in patients with relapsing remitting MS (RRMS) increases levels of NAA in cerebral NAWM and improves clinical symptoms. Methods:27 RRMS patients were included in a 4 weeks proof-of-concept, randomized, double-blind placebo-controlled trial (ROCHIMS) to investigate whether bosentan 62.5 mg twice daily could increase the NAA/creatine (NAA/Cr) ratio in NAWM of the centrum semiovale. Magnetic resonance imaging (MRI) assessing CBF and NAA/Cr, and clinical evaluations were performed at baseline and at end of study. Separately from the clinical trial, 10 healthy controls underwent the same baseline multimodal brain MRI protocol as the MS patients. Results:Eleven patients in the bosentan arm and thirteen patients in the placebo arm completed the study. Bosentan did not increase CBF. However, we found that CBF in the patients was not different from that of the healthy controls. There were no effects on NAA levels and clinical symptoms. Conclusions:Our study showed that CBF in RRMS patients is not always decreased and that bosentan has no effect when CBF values are within the normal range. We hypothesize that in our patients there was no significant astrocytic production of ET-1 because they had a mild disease course, with minimal local inflammatory activity. Future studies with bosentan in MS should focus on patients with elevated ET-1 levels in cerebrospinal fluid or blood

Numbers and language : what's new in the past 25 years?

Numerous studies in psychology, cognitive neuroscience and psycholinguistics have used pictures of objects as stimulus materials. Currently, authors engaged in cross-linguistic work or wishing to run parallel studies at multiple sites where different languages are spoken must rely on rather small sets of black-and-white or colored line drawings. These sets are increasingly experienced as being too limited. Therefore, we constructed a new set of 750 colored pictures of concrete concepts. This set, MultiPic, constitutes a new valuable tool for cognitive scientists investigating language, visual perception, memory and/or attention in monolingual or multilingual populations. Importantly, the MultiPic databank has been normed in six different European languages (British English, Spanish, French, Dutch, Italian and German). All stimuli and norms are freely available at http://www.bcbl.eu/databases/multipi

Pengaruh Brand Trust dan Brand Equity terhadap Loyalitas Konsumen pada Produk Kosmetik Wardah (Survey Konsumen pada PT. Paragon Technology And Innovation Cabang Pekanbaru)

The purpose of this study was to determine the influence of brand trust ( X1 ) and brand equity ( X2 ) customer loyalty ( Y ) in cosmetic products Wardah ( consumer survey on PT . Paragon technology and innovation branches pekanbaru ) . The method in this research is quantitatively using SPSS 21 program , where samples were used that consumers using cosmetic products Wardah by respondents as many as 100 people sampling technique is accidental sampling using the formula slovin . The results showed that the test results simultaneously obtained from the F count was 34.888 while the value of F table 3.090 . This means that F count> F table and significant value 0,000 < alpha of 0.05 . This means that brand trust and brand equity simultaneously significant effect on consumer loyalty to cosmetic products Wardah

Low performance on mathematical tasks in preschoolers : the importance of domain-general and domain-specific abilities

Background: Different domain‐specific and domain‐general cognitive precursors play a key role in the development of mathematical abilities. The contribution of these domains to mathematical ability changes during development. Primary school‐aged children who show mathematical difficulties form a heterogeneous group, but it is not clear whether this also holds for preschool low achievers (LAs) and how domain‐specific and domain‐general abilities contribute to mathematical difficulties at a young age. The aim of this study was to explore the cognitive characteristics of a sample of preschool LAs and identify sub‐types of LAs. Methods: 81 children were identified as LAs from 283 preschoolers aged 3 to 5 years old and were assessed on a number of domain‐general and domain‐specific tasks. Results: Cluster analysis revealed four subgroups of LAs in mathematics: (1) a weak processing sub‐type; (2) a general mathematical LAs sub‐type; (3) a mixed abilities sub‐type; and (4) a visuo‐spatial deficit sub‐type. Whilst two of the groups showed specific domain‐general difficulties, none showed only domain‐specific difficulties. Conclusions: Current findings suggest that preschool LAs constitute a heterogeneous group and stress the importance of domain‐general factors for the development of mathematical abilities during the preschool years

Indexing the approximate number system

This is the author’s version of a work that was accepted for publication in Acta Psychologica. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published at: http://dx.doi.org/10.1016/j.actpsy.2013.11.009Much recent research attention has focused on understanding individual differences in the Approximate Number System, a cognitive system believed to underlie human mathematical competence. To date researchers have used four main indices of ANS acuity, and have typically assumed that they measure similar properties. Here we report a study which questions this assumption. We demonstrate that the Numerical Ratio Effect has poor testretest reliability and that it does not relate to either Weber fractions or accuracy on nonsymbolic comparison tasks. Furthermore, we show that Weber fractions follow a strongly skewed distribution and that they have lower test-retest reliability than a simple accuracy measure. We conclude by arguing that in future researchers interested in indexing individual differences in ANS acuity should use accuracy figures, not Weber fractions or Numerical Ratio Effects

A Mechanistic Study of the Association Between Symbolic Approximate Arithmetic Performance and Basic Number Magnitude Processing Based on Task Difficulty

Two types of number magnitude processing – semantic and spatial – are significantly correlated with children’s arithmetic performance. However, it remains unclear whether these abilities are independent predictors of symbolic approximate arithmetic performance. The current study addressed this question by assessing 86 kindergartners (mean age of 5 years and 7 months) on semantic number processing (number comparison task), spatial number processing (number line estimation task), and symbolic approximate arithmetic performance with different levels of difficulty. The results showed that performance on both tasks of number magnitude processing was significantly correlated with symbolic approximate arithmetic performance, but the strength of these correlations was moderated by the difficulty level of the arithmetic task. The simple symbolic approximate arithmetic task was equally related to both tasks. In contrast, for more difficult symbolic approximate arithmetic tasks, the contribution of number comparison ability was smaller than that of the number line estimation ability. These results indicate that the strength of contribution of the different types of numerical processing depends on the difficulty of the symbolic approximate arithmetic task