2,112 research outputs found
Bench-to-bedside review: Bacterial pneumonia with influenza - pathogenesis and clinical implications
Bench-to-bedside review: Bacterial pneumonia with influenza - pathogenesis and clinical implications
Interleukin-10 negatively regulates local cytokine and chemokine production but does not influence antibacterial host defense during murine pneumococcal meningitis.
To determine the role of endogenous interleukin-10 (IL-10) in local host defense during pneumococcal meningitis, the inflammatory responses of IL-10-gene-deficient and wild-type mice after the induction of meningitis were compared. The absence of IL-10 was associated with higher cytokine and chemokine concentrations and a more pronounced infiltrate, but antibacterial defense or survival was not influenced
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