1,511 research outputs found
Bond Repurchases: A Teaching Case
Companies can buy back and retire their own bonds before maturity, resulting in a possible gain or loss on the extinguishment of debt. What would happen if a company repurchased its own bonds before maturity but did not retire them, potentially holding them for resale later before the bonds mature? This case gives students an opportunity to explore how the repurchase of bonds held for resale should be accounted for, including the repurchase transaction, the disposition of any gain or loss, and the possible transaction to resell the bonds later
The burden of proof: the current state of atrial fibrillation prevention and treatment trials
Atrial fibrillation (AF) is an age-related arrhythmia of enormous socioeconomic significance. In recent years, our understanding of the basic mechanisms that initiate and perpetuate AF has evolved rapidly, catheter ablation of AF has progressed from concept to reality, and recent studies suggest lifestyle modification may help prevent AF recurrence. Emerging developments in genetics, imaging, and informatics also present new opportunities for personalized care. However, considerable challenges remain. These include a paucity of studies examining AF prevention, modest efficacy of existing antiarrhythmic therapies, diverse ablation technologies and practice, and limited evidence to guide management of high-risk patients with multiple comorbidities. Studies examining the long-term effects of AF catheter ablation on morbidity and mortality outcomes are not yet completed. In many ways, further progress in the field is heavily contingent on the feasibility, capacity, and efficiency of clinical trials to incorporate the rapidly evolving knowledge base and to provide substantive evidence for novel AF therapeutic strategies. This review outlines the current state of AF prevention and treatment trials, including the foreseeable challenges, as discussed by a unique forum of clinical trialists, scientists, and regulatory representatives in a session endorsed by the Heart Rhythm Society at the 12th Global CardioVascular Clinical Trialists Forum in Washington, DC, December 3–5, 2015
Contrasting carbonate depositional systems for Pliocene cool-water limestones cropping out in central Hawke's Bay, New Zealand
Pliocene limestone formations in central Hawke's Bay (eastern North Island, New Zealand) accumulated on and near the margins of a narrow forearc basin seaway within the convergent Australia/Pacific plate boundary zone. The active tectonic setting and varied paleogeographic features of the limestone units investigated, in association with probable glacioeustatic sea-level fluctuations, resulted in complex stratigraphic architectures and contrasting types of carbonate accumulation on either side of the seaway. Here, we recognise recurring patterns of sedimentary facies, and sequences and systems tracts bounded by key physical surfaces within the limestone sheets. The facies types range from Bioclastic (B) to Siliciclastic (S) end-members via Mixed (M) carbonate-siliciclastic deposits. Skeletal components are typical cool-water associations dominated by epifaunal calcitic bivalves, bryozoans, and especially barnacles. Siliciclastic contents vary from one formation to another, and highlight siliciclastic-rich limestone units in the western ranges versus siliciclastic-poor limestone units in the eastern coastal hills. Heterogeneities in facies types, stratal patterns, and also in diagenetic pathways between eastern and western limestone units are considered to originate in the coeval occurrence in different parts of the forearc basin of two main morphodynamic carbonate systems over time
Epicyclic oscillations of non-slender fluid tori around Kerr black holes
Considering epicyclic oscillations of pressure-supported perfect fluid tori
orbiting Kerr black holes we examine non-geodesic (pressure) effects on the
epicyclic modes properties. Using a perturbation method we derive fully general
relativistic formulas for eigenfunctions and eigenfrequencies of the radial and
vertical epicyclic modes of a slightly non-slender, constant specific angular
momentum torus up to second-order accuracy with respect to the torus thickness.
The behaviour of the axisymmetric and lowest-order () non-axisymmetric
epicyclic modes is investigated. For an arbitrary black hole spin we find that,
in comparison with the (axisymmetric) epicyclic frequencies of free test
particles, non-slender tori receive negative pressure corrections and exhibit
thus lower frequencies. Our findings are in qualitative agreement with the
results of a recent pseudo-Newtonian study of analogous problem defined within
the Paczy{\'n}ski-Wiita potential. Implications of our results on the
high-frequency QPO models dealing with epicyclic oscillations are addressed.Comment: 24 pages, 8 figure
The Ursinus Weekly, November 12, 1970
Alan Novak resigns as USGA President • Pettit inaugurated President at Founders\u27 Day convocation • Ambassador Daniel Nyaho addresses Forum audience • False alarms • Editorial: In correspondence • Student Committee statement • Election committee counts ballots • Craft appointed legal chairman • Wanted: Fearless leader • Administration answers: Dean Ruth Harris • Draftees killed at higher rates than enlisted men in U.S. Army • Bill Hafer schedules Mock U.N. Conference • U.C. Bears trip Dickinson; Adrian marches onward • Harriers win twice; Next target: MACs • Bakermen score 1st victory over Haverford since WW2https://digitalcommons.ursinus.edu/weekly/1132/thumbnail.jp
Searching for periodic sources with LIGO. II: Hierarchical searches
The detection of quasi-periodic sources of gravitational waves requires the
accumulation of signal-to-noise over long observation times. If not removed,
Earth-motion induced Doppler modulations, and intrinsic variations of the
gravitational-wave frequency make the signals impossible to detect. These
effects can be corrected (removed) using a parameterized model for the
frequency evolution. We compute the number of independent corrections
required for incoherent search strategies which use stacked
power spectra---a demodulated time series is divided into segments of
length , each segment is FFTed, the power is computed, and the
spectra are summed up. We estimate that the sensitivity of an all-sky search
that uses incoherent stacks is a factor of 2--4 better than would be achieved
using coherent Fourier transforms; incoherent methods are computationally
efficient at exploring large parameter spaces. A two-stage hierarchical search
which yields another 20--60% improvement in sensitivity in all-sky searches for
old (>= 1000 yr) slow (= 40 yr) fast (<=
1000 Hz) pulsars. Assuming 10^{12} flops of effective computing power for data
analysis, enhanced LIGO interferometers should be sensitive to: (i) Galactic
core pulsars with gravitational ellipticities of \epsilon\agt5\times 10^{-6}
at 200 Hz, (ii) Gravitational waves emitted by the unstable r-modes of newborn
neutron stars out to distances of ~8 Mpc, and (iii) neutron stars in LMXB's
with x-ray fluxes which exceed . Moreover,
gravitational waves from the neutron star in Sco X-1 should be detectable is
the interferometer is operated in a signal-recycled, narrow-band configuration.Comment: 22 Pages, 13 Figure
Juxtaposition of Chemical and Mutation-Induced Developmental Defects in Zebrafish Reveal a Copper-Chelating Activity for Kalihinol F
SummaryA major hurdle in using complex systems for drug screening is the difficulty of defining the mechanistic targets of small molecules. The zebrafish provides an excellent model system for juxtaposing developmental phenotypes with mechanism discovery using organism genetics. We carried out a phenotype-based screen of uncharacterized small molecules in zebrafish that produced a variety of chemically induced phenotypes with potential genetic parallels. Specifically, kalihinol F caused an undulated notochord, defects in pigment formation, hematopoiesis, and neural development. These phenotypes were strikingly similar to the zebrafish mutant, calamity, an established model of copper deficiency. Further studies into the mechanism of action of kalihinol F revealed a copper-chelating activity. Our data support this mechanism of action for kalihinol F and the utility of zebrafish as an effective system for identifying therapeutic and target pathways
The s-process weak component: uncertainties due to convective overshooting
Using a new s-nucleosynthesis code, coupled with the stellar evolution code
Star2003, we performed simulations to study the impact of the convection
treatment on the s-process during core He-burning of a 25 Msun star (ZAMS mass)
with an initial metallicity of Z=0.02. Particular attention was devoted to the
impact of the extent of overshooting on the s-process efficiency. The results
show enhancements of about a factor 2-3 in s-process efficiency (measured as
the average overproduction factor of the 6 s-only nuclear species with
) with overshooting parameter values in the range
0.01-0.035, compared to results obtained with the same model but without
overshooting. The impact of these results on the p-process model based on type
II supernovae is discussed.Comment: 7 pages, 4 figures, accepted for publication in Astronomy &
Astrophysic
Anatomy and origin of authochthonous late Pleistocene forced regression deposits, east Coromandel inner shelf, New Zealand: implications for the development and definition of the regressive systems tract
High-resolution seismic reflection data from the east Coromandel coast, New Zealand, provide details of the sequence stratigraphy beneath an autochthonous, wave dominated inner shelf margin during the late Quaternary (0-140 ka). Since c. 1 Ma, the shelf has experienced limited subsidence and fluvial sediment input, producing a depositional regime characterised by extensive reworking of coastal and shelf sediments during glacio-eustatic sea-level fluctuations. It appears that only one complete fifth-order (c. 100 000 yr) depositional sequence is preserved beneath the inner shelf, the late Pleistocene Waihi Sequence, suggesting any earlier Quaternary sequences were mainly cannibalised into successively younger sequences. The predominantly Holocene-age Whangamata Sequence is also evident in seismic data and modern coastal deposits, and represents an incomplete depositional sequence in its early stages of formation. A prominent aspect of the sequence stratigraphy off parts of the east Coromandel coast is the presence of forced regressive deposits (FRDs) within the regressive systems tract (RST) of the late Pleistocene Waihi Sequence. The FRDs are interpreted to represent regressive barrier-shoreface sands that were sourced from erosion and onshore reworking of underlying Pleistocene sediments during the period of slow falling sea level from isotope stages 5 to 2 (c. 112-18 ka). The RST is volumetrically the most significant depositional component of the Waihi Sequence; the regressive deposits form a 15-20 m thick, sharp-based, tabular seismic unit that downsteps and progrades continuously across the inner shelf. The sequence boundary for the Waihi Sequence is placed at the most prominent, regionally correlative, and chronostratigraphically significant surface, namely an erosional unconformity characterised in many areas by large incised valleys that was generated above the RST. This unconformity is interpreted as a surface of maximum subaerial erosion generated during the last glacial lowstand (c. 18 ka). Although the base of the RST is associated with a prominent regressive surface of erosion, this is not used as the sequence boundary as it is highly diachronous and difficult to identify and correlate where FRDs are not developed. The previous highstand deposits are limited to subaerial barrier deposits preserved behind several modern Holocene barriers along the coast, while the transgressive systems tract is preserved locally as incised-valley fill deposits beneath the regressive surface of erosion at the base of the RST. Many documented late Pleistocene RSTs have been actively sourced from fluvial systems feeding the shelf and building basinward-thickening, often stacked wedges of FRDs, for which the name allochthonous FRDs is suggested. The Waihi Sequence RST is unusual in that it appears to have been sourced predominantly from reworking of underlying shelf sediments, and thus represents an autochthonous FRD. Autochthonous FRDs are also present on the Forster-Tuncurry shelf in southeast Australia, and may be a common feature in other shelf settings with low subsidence and low sediment supply rates, provided shelf gradients are not too steep, and an underlying source of unconsolidated shelf sediments is available to source FRDs. The preservation potential of such autochthonous FRDs in ancient deposits is probably low given that they are likely to be cannibalised during subsequent sea-level falls
Effective field theory analysis of the self-interacting chameleon
We analyse the phenomenology of a self-interacting scalar field in the
context of the chameleon scenario originally proposed by Khoury and Weltman. In
the absence of self-interactions, this type of scalar field can mediate long
range interactions and simultaneously evade constraints from violation of the
weak equivalence principle. By applying to such a scalar field the effective
field theory method proposed for Einstein gravity by Goldberger and Rothstein,
we give a thorough perturbative evaluation of the importance of non-derivative
self-interactions in determining the strength of the chameleon mediated force
in the case of orbital motion. The self-interactions are potentially dangerous
as they can change the long range behaviour of the field. Nevertheless, we show
that they do not lead to any dramatic phenomenological consequence with respect
to the linear case and solar system constraints are fulfilled.Comment: 15 pages, 2 figures. Final version accepted for publication on
General Relativity and Gravitatio
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