13 research outputs found
Understanding and governing learning in sustainability transitions: A review
Many transitions scholars underscore the importance of learning in sustainability transitions, but the associated learning processes have hardly been conceptualised. The diverse, well-established research fields related to learning are broadly ignored or loosely applied. In this paper, we systematically explore four interesting learning traditions in terms of their value for gaining an in-depth understanding of learning in sustainability transitions and their relevance for fostering learning, by connecting them to key features of transitions. The selected learning traditions from different disciplinary backgrounds provide valuable insights. None of them sufficiently addresses the complexity of transitions. They include, however, a diversity of relevant learning contexts. We conclude that they have value for investigating new areas such as learning in socio-technological regimes and in later phases of a transition, while enlightening forms of learning that have not yet been fully recognised in transition studies, such as superficial learning, unlearning, and learning to resist change
Inclusion in responsible innovation: revisiting the desirability of opening up
We investigate opening up, a crucial aim of responsible innovation, in the situation of companies initiating sector-wide change in order to take societal responsibility. Two case studies in agriculture were conducted, using a framing perspective that enlightens how issues are (re-)defined and acquire meaning in conversations. For both industry-led innovation initiatives, this showed when and how the initiatives’ issue frames opened up and closed down. The results suggest that the inclusion of a
Activation of the human immune system by chemotherapeutic or targeted agents combined with the oncolytic parvovirus H-1
Genomic investigations of unexplained acute hepatitis in children
Since its first identification in Scotland, over 1,000 cases of unexplained paediatric hepatitis in children have been reported worldwide, including 278 cases in the UK1. Here we report an investigation of 38 cases, 66 age-matched immunocompetent controls and 21 immunocompromised comparator participants, using a combination of genomic, transcriptomic, proteomic and immunohistochemical methods. We detected high levels of adeno-associated virus 2 (AAV2) DNA in the liver, blood, plasma or stool from 27 of 28 cases. We found low levels of adenovirus (HAdV) and human herpesvirus 6B (HHV-6B) in 23 of 31 and 16 of 23, respectively, of the cases tested. By contrast, AAV2 was infrequently detected and at low titre in the blood or the liver from control children with HAdV, even when profoundly immunosuppressed. AAV2, HAdV and HHV-6 phylogeny excluded the emergence of novel strains in cases. Histological analyses of explanted livers showed enrichment for T cells and B lineage cells. Proteomic comparison of liver tissue from cases and healthy controls identified increased expression of HLA class 2, immunoglobulin variable regions and complement proteins. HAdV and AAV2 proteins were not detected in the livers. Instead, we identified AAV2 DNA complexes reflecting both HAdV-mediated and HHV-6B-mediated replication. We hypothesize that high levels of abnormal AAV2 replication products aided by HAdV and, in severe cases, HHV-6B may have triggered immune-mediated hepatic disease in genetically and immunologically predisposed children
Communicating tensions among incumbents about system innovation in the Dutch dairy sector
This article investigates the ways in which innovating incumbents address and deal with tensions in their daily conversations in a case of an dairy initiative aiming for sector transformation. Analysis of meetings shows that innovating incumbents employ three strategies to address and deal with tensions such as concerns about the initiative's impact: voicing concerns, questioning as starting point and questioning as response. In these ways, they address tensions at the boundaries between representative and initiative and between representative and constituency. The assigned staff members of initiatives
Historische en hedendaagse systeem-innovaties in de glastuinbouw en varkenshouderij:Een innovatie-sociologische analyse : eindrapport voor het Transforum project: 'Historical and future transitions in agriculture and food
Exploring ways to reconcile accountability and learning in the evaluation of niche experiments
Co-evolution of smart energy products and services:a novel approach towards smart grids
\u3cp\u3eIn this paper we present our project on interdisciplinary evaluations of existing smart grid environments regarding (1) the technical performance of smart energy products and services, (2) end users perceptions, (3) stakeholder processes and (4) market aspects. Our evaluations are based on data and information originating from real life pilots and demonstration projects in the field of smart grids in residential areas in the Netherlands and in Austria. The so-called CESEPS project is executed in the European ERA-Net Smart Grids Plus program. CESEPS stands for Co-Evolution of Smart Energy Product and Services. Its main objective is to support the development of smart energy products and services for local smart grids that better respond to the demands and concerns of all stakeholders in terms of performance, cost, reliability, safety and robustness, sustainability and energy-efficiency, and end users' comfort. Besides comparative data analyses and user surveys, this three year project comprises simulation activities to model existing and innovative smart grid energy products to evaluate their feasibility, given the aspects above mentioned. In this paper our approach will be explained and illustrated by several examples of ongoing subtopics of research and knowledge dissemination among stakeholders in the smart grid sector.\u3c/p\u3