THYROID METABOLISM IN CHILDREN AND ADULTS USING VERY SMALL (NANOCURIE) DOSES OF IODINEsup125sup 125 AND IODINEsup13sup 13sup1sup 1

A new technique for measuring the radioiodine content of the human thyroid in vivo with nanocurie amounts of I/sup 131/ and I/sup 125/ is described. The technique gives a measure of the thickness of neck tissue over the thyroid; values of 0.4 and 2.0 cm have been found in the subjects studied thus far. Results on 6 normal adults show uptake at 7 days after oral ingestion varies between 15 and 29%, with biological half times between 27 days and infinity. Results on 8 normal children (ages 4 to 10 yr) show little or no difference from adults as far as the data extend (15 days post oral ingestion). Uptakes vary between 9.5 and 27%, and biological half times are long compared to the 8-day physical haif life. (auth

The National Laboratory Gene Library Project

The two National Laboratories at Livermore and Los Alamos have played a prominent role in the development and application of flow cytometry and sorting to chromosome classification and purification. Both laboratories began to receive numerous requests for specific human chromosomal types purified by flow sorting for gene library construction, but these requests were difficult to satisfy due to time and personnel constraints. The Department of Energy, through its Office of Health and Environmental Research, has a long-standing interest in the human genome in general and in the mutagenic and carcinogenic effects of energy-related environmental pollutants in particular. Hence, it was decided in 1983 to use the flow construct chromosome-specific gene libraries to be made available to the genetic research community. The National Laboratory Gene Library Project was envisioned as a practical way to deal with requests for sorted chromosomes, and also as a way to promote increased understanding of the human genome and the effects of mutagens and carcinogens on it. The strategy for the project was developed with the help of an advisory committee as well as suggestions and advice from many other geneticists. 4 refs., 2 tabs