Современные аспекты патогенеза и лечения эндокринного бесплодия

Приведены литературные данные о патогенезе, причинах, клинических формах, диагностике и лечении эндокринного бесплодия. Описаны причины возникновения и развития синдрома поликистозных яичников и схемы стимуляции овуляции.Наведено літературні дані про патогенез, причини, клінічні форми, діагностику й лікування ендокринного безпліддя. Описано причини виникнення й розвитку синдрому полікістозних яєчників і схеми стимуляції овуляції.The literature data about the pathogenesis, causes, clinical forms, diagnosis, and treatment for endocrine infertility are reported. The causes and development of polycystic ovary syndrome as well as the schemes of ovulation stimulation are described

Pancreatic fibrosis correlates with exocrine pancreatic insufficiency after pancreatoduodenectomy

Background: Obstruction of the pancreatic duct can lead to pancreatic fibrosis. We investigated the correlation between the extent of pancreatic fibrosis and the postoperative exocrine and endocrine pancreatic function. Methods: Fifty-five patients who were treated for pancreatic and periampullary carcinoma and 19 patients with chronic pancreatitis were evaluated. Exocrine pancreatic function was evaluated by fecal elastase-1 test, while endocrine pancreatic function was assessed by plasma glucose level. The extent of fibrosis, duct dilation and endocrine tissue loss was examined histopathologically. Results: A strong correlation was found between pancreatic fibrosis and elastase-1 level less than 100 μg/g (p < 0.0001), reflecting severe exocrine pancreatic insufficiency. A strong correlation was found between pancreatic fibrosis and endocrine tissue loss (p < 0.0001). Neither pancreatic fibrosis nor endocrine tissue loss were correlated with the development of postoperative diabetes mellitus. Duct dilation alone was neither correlated with exocrine nor with endocrine function loss. Conclusion: The majority of patients develop severe exocrine pancreatic insufficiency after pancreatoduodenectomy. The extent of exocrine pancreatic insufficiency is strongly correlated with preoperative fibrosis. The loss of endocrine tissue does not correlate with postoperative diabetes mellitus. Preoperative dilation of the pancreatic duct per se does not predict exocrine or endocrine pancreatic insufficiency postoperatively. Copyrigh

Viscosity and fission time scale of^{156}Dy

In the fusion-fission reaction Ar-40+Cd-116-->Dy-156-->fission, performed at beam energies E(b) = 216 MeV and 238 MeV, gamma rays were measured in coincidence with fission fragments. The gamma-ray spectra are interpreted using a modified version of the statistical-model code CASCADE. From a comparison of the experimental and calculated spectra it is deduced that the nuclear viscosity is in the range 0.01 <gamma <4. The extracted fission time scale is of the order of 10(-19) s

Uphill and downhill walking in unilateral lower limb amputees

Objective: To study adjustment strategies in unilateral amputees in uphill and downhill walking. Design: observational cohort study. Subjects: Seven transfemoral, 12 transtibial unilateral amputees and 10 able-bodied subjects. Methods: In a motion analysis laboratory the subjects walked over a level surface and an uphill and downhill slope. Gait velocity and lower limb joint angles were measured. Results: In uphill walking hip and knee flexion at initial contact and hip flexion in swing were increased in the prosthetic limb of transtibial amputees. In downhill walking transtibial amputees showed more knee flexion on the prosthetic side in late stance and swing. Transfemoral amputees were not able to increase prosthetic knee flexion in uphill and downhill walking. An important adjustment strategy in both amputee Groups was a smaller hip extension in late stance in uphill and downhill walking, probably related with a shorter step length. In addition, amputees increased knee flexion in early stance in the non-affected limb in uphill walking to compensate for the shorter prosthetic limb length. In downhill walking fewer adjustments were necessary, since the shorter prosthetic limb already resulted in lowering of the body. Conclusion: Uphill and downhill walking can be trained in rehabilitation, which may improve safety and confidence of amputees. Prosthetic design should focus on better control of prosthetic knee flexion abilities without reducing stability. (c) 2007 Elsevier B.V. All fights reserved

African Studies Abstracts Online: number 51, 2015

ASA Online provides a quarterly overview of journal articles and edited works on Africa in the field of the social sciences and the humanities available in the ASC library. Issue 51 (2015). African Studies Centre, Leiden.ASC – Publicaties niet-programma gebonde