The application software for the instrument control unit of the NISP instrument of the Euclid mission: final status and lessons learned after delivery of the flight version

In this paper we describe the final status of the application software (ASW) of the instrument control unit (ICU) of NISP, the Near-Infrared Spectro-Photometer of the Euclid mission, as the version for Flight has been tested and delivered to the industry for the next integration phases. This software is based on a real-time operating system (RTEMS) and will interface with all the subunits of NISP, as well as the command and data management unit (CDMU) of the spacecraft for telecommand and housekeeping management. We will describe in particular the final tests and the main obstacles which had to be faced in order to implement an efficient and reliable interface with all the NISP subsystems

Early experiences with a porcine hepatocyte-based bioartificial liver in acute hepatic failure patients

Orthotopic liver transplantation (OLT) is the only effective therapeutic modality in severe acute hepatic failure (AHF). The scarcity of organs for transplantation leads to an urgent necessity for temporary liver support treatments in AHF patients. A hepatocyte-based bioartificial liver (BAL) is under investigation with the main purpose to serve as bridging treatment until a liver becomes available for OLT or to promote spontaneous liver regeneration. We developed a novel radial-flow bioreactor (RFB) for three-dimensional, high-density hepatocyte culture and an integrated pumping apparatus in which, after plasmapheresis, the patient's plasma is recirculated through the hepatocyte-filled RFB. Two hundred thirty grams of freshly isolated porcine hepatocytes were loaded into the RFB for clinical liver support treatment. The BAL system was used 8 times in supporting 7 AHF patients in grade III-IV coma, all waiting for an urgent OLT Three patients with no history of previous liver diseases were affected by fulminant hepatic failure (FHF) due to hepatitis B virus, 3 by primary non-function (PNF) of the transplanted liver, and one by AHF due to previous abdominal trauma and liver surgery. Six out of 7 patients underwent OLT following BAL treatment(s), which lasted 6-24 hours. All patients tolerated the procedures well, as shown by an improvement in the level of encephalopathy, a decrease in serum ammonia, transaminases and an amelioration of the prothrombin time, with full neurological recovery after OLT Our initial clinical experience confirms the safety of this BAL configuration and suggests its clinical efficacy as a temporary liver support system in AHF patients

The application software of the instrument control unit of Euclid-NISP: ready for qualification tests

In this paper we describe the application software (ASW) of the instrument control unit (ICU) of NISP, the Near-Infrared Spectro-Photometer of the Euclid mission. This software is based on a real-time operating system (RTEMS) and will interface with all the subunits of NISP, as well as the command and data management unit (CDMU) of the spacecraft for telecommand and housekeeping management

Oncoplastic and reconstructive surgery in SENONETWORK Italian breast centers: lights and shadows

: • Despite the significance of oncoplastic procedure, an italian database is lacking. • Senonetwork established a multidisciplinary survey to assess their safety and efficacy. • Reconstructive outcomes were positive across low and high-volume centers. • After mastectomy, implant-based techniques are common. DTI reconstruction is advantageuos. • This contributes to the global understanding of effective strategies against breast cancer