18 research outputs found
EUROfusion-theory and advanced simulation coordination (E-TASC): programme and the role of high performance computing
The paper is a written summary of an overview oral presentation given at the 1st Spanish Fusion HPC Workshop that took place on the 27th November 2020 as an online event. Given that over the next few years ITER will move to its operation phase and the European-DEMO design will be significantly advanced, the EUROfusion consortium has initiated a coordination effort in theory and advanced simulation to address some of the challenges of the fusion research in Horizon EUROPE (2021-2027), i.e. the next EU Framework Programme for Research and Technological Development. This initiative has been called E-TASC that stands for EUROfusion-Theory and Advanced Simulation Coordination. The general and guiding principles of E-TASC are summarized in the paper. In addition, an overview of the scientific results obtained in a pilot phase (2019-2020) of E-TASC are provided while highlighting the importance of the required progress in computational methods and HPC techniques. In the initial phase, five pilot theory and simulation tasks were initiated: 1. Towards a validated predictive capability of the L-H transition and pedestal physics; 2. Electron runaway in tokamak disruptions in the presence of massive material injection; 3. Fast code for the calculation of neoclassical toroidal viscosity in stellarators and tokamaks; 4. Development of a neutral gas kinetics modular code; 5. European edge and boundary code for reactor-relevant devices. In this paper we report on recent progress made by each of these projects.</p
Multicenter evaluation of the nitrate reductase assay for drug resistance detection of Mycobacterium tuberculosis
The performance of the nitrate reductase assay was evaluated in a multicenter laboratory study to detect resistance of Mycobacterium tuberculosis to the first-line anti-tuberculosis drugs rifampicin, isoniazid, ethambutol and streptomycin using a set of coded isolates. Compared with the gold standard proportion method on Löwenstein-Jensen medium, the assay was highly accurate in detecting resistance to rifampicin, isoniazid and ethambutol with an accuracy of 98%, 96.6% and 97.9%, respectively. For streptomycin, discrepant results were obtained with an overall accuracy of 85.3%. The assay proved easy to be implemented in countries with limited laboratory facilities
Healthcare resource utilisation due to chronic urticaria in Europe, South America, and Central America: findings from visit 1 of the worldwide aware study
Charite, Dept Dermatol & Allergy, Allergie Ctr Charite ECARF, Berlin, GermanyHosp Gen Plaza Salud, Santo Domingo, Dominican RepNovartis Pharma AG, Basel, SwitzerlandUniv Fed São Paulo, Sau Paulo, BrazilUniv Santo Amaro, Sau Paulo, BrazilCtr Hosp Univ Poitiers, Serv Dermatol, Poitiers, FranceRTI Hlth Solut, Res Triangle Pk, NC USAVall dHebron Hosp, Internal Med, Barcelona, SpainUniv Manchester, Salford Royal NHS Fdn Trust, Salford, Lancs, EnglandRTI Hlth Solut, Manchester, Lancs, EnglandCareggi Univ Hosp, SOD Immunoallergy, Florence, ItalyHosp Arnau Vilanova, Dept Dermatol, Valencia, SpainUniv Fed São Paulo, Sau Paulo, BrazilWeb of Scienc
Chronic inducible urticaria (CIndU) in Europe, Central America, and South America: findings from visit 1 of the worldwide aware study
Charite, Allergie Ctr Charite ECARF, Dept Dermatol & Allergy, Berlin, GermanyHosp Gen Plaza Salud, Santo Domingo, Dominican RepNovartis Pharma AG, Basel, SwitzerlandUniv Fed São Paulo, Sau Paulo, BrazilUniv Santo Amaro, Sau Paulo, BrazilCtr Hosp Univ Poitiers, Serv Dermatol, Poitiers, FranceRTI Hlth Solut, Res Triangle Pk, NC USAVall Dhebron Hosp, Internal Med, Barcelona, SpainUniv Manchester, Salford Royal NHS Fdn Trust, Salford, Lancs, EnglandRTI Hlth Solut, Manchester, Lancs, EnglandSOD Immunoallergy Careggi Univ Hosp, Florence, ItalyHosp Arnau Vilanova, Dermatol Dept, Valencia, SpainUniv Fed São Paulo, Sau Paulo, BrazilWeb of Scienc