Propuesta de un centro educativo básico regular de primaria y secundaria basado en el confort térmico en el distrito El Porvenir 2020

La presente tesis titulada “Propuesta de un centro educativo básico regular de primaria y secundaria basado en el confort térmico en el distrito El Porvenir 2020” se desarrolla con el propósito de diseñar un centro educativo, el cual se pretende ubicar en el sector Alto Trujillo ubicado en el distrito El Porvenir, Provincia de Trujillo. Se pretende diseñar el centro educativo básico regular de primaria y secundaria en este sector puesto que los centros educativos que se encuentran establecidos en este lugar no cuentan con una buena infraestructura, perjudicando el nivel académico de los estudiantes, además que la mayoría de estos son solo de nivel primaria. Para poder desarrollar un buen diseño arquitectónico se tuvo que estudiar los requerimientos establecidos por el Ministerio de educación (MINEDU), puesto que es la institución que se encarga de los equipamientos educativos. También se analizó 4 casos arquitectónicos de equipamientos educativos, 2 nacionales y 2 internacionales. Como resultado se obtuvo que, siguiendo todos los criterios arquitectónicos establecidos por MINEDU, además del análisis de casos se desarrolló un óptimo diseño del centro educativo en el sector Alto Trujillo.This thesis entitled "Proposal for a regular elementary and secondary basic educational center based on thermal comfort in the El Porvenir 2020 district" is developed with the purpose of designing an educational center, which is intended to be located in the Alto Trujillo sector located in the El Porvenir district, Trujillo Province. It is intended to design the regular basic primary and secondary education center in this sector since the educational centers that are established in this place do not have a good infrastructure, damaging the academic level of the students, in addition that most of these are only primary level. In order to develop a good architectural design, the requirements established by the Ministry of education (MINEDU) had to be studied, since it is the institution that is in charge of educational equipment. Four architectural cases of educational facilities, 2 national and 2 international, were also analyzed. As a result, it was obtained that following all the architectural criteria established by MINEDU, in addition to the case analysis, an optimal design of the educational center in the Alto Trujillo sector was developed

“Valiente”: Escritura narrativa para un cortometraje sobre la normalización de la violencia de género

Este proyecto consiste en la presentación de la propuesta narrativa y guion para un cortometraje donde se va a mostrar el machismo que ha sido normalizado en la sociedad y que pasa desapercibido. Para su desarrollo, se empezó con una investigación exhaustiva sobre el tema ya que, de esta manera, podemos plasmar mejor la realidad. Se realizó la historia considerando lo que queremos mostrar y transmitir. Empezamos con el storyline para tener la idea general de la historia, continuamos con la sinopsis y el guion. Una vez terminado esto, se procedió a hacer un guion técnico acompañado de un photoboard que sirve como referencia al momento de grabar. En paralelo se trabajó el área de arte donde se colocó en una carpeta el moodboard, las locaciones, el vestuario y la utilería necesaria para la realización del cortometraje. Posteriormente, se hizo un plan de trabajo desglosado por semanas para tener mapeado todas las actividades por realizar. Junto con eso, se elaboró el presupuesto del proyecto para poder hacer el casting con los actores en mente, tener las locaciones y toda la utilería lista para, luego, proceder con el rodaje. Finalizado los días de filmación, pasamos a la edición siguiendo los requerimientos planteados en un inicio

Water and sediment toxicity in a river affected by former mining residues

A bacia do Rio Ribeira de Iguape foi palco de intensa atividade de mineração de chumbo e, como resultado, estima-se que o \ud rio Ribeira de Iguape tenha recebido a descarga de aproximadamente 5,5 t/mês de materiais ricos em As, Ba, Cd, Pb, Cu, Cr e \ud Zn. No presente trabalho, foi analisada a toxicidade de sedimentos e águas coletados ao longo do rio com o intuito de avaliar \ud a qualidade ambiental, tendo sido realizadas 3 campanhas de coleta, entre 2009 e 2010. Os testes de toxicidade aguda foram \ud conduzidos com o cladócero Daphnia similis, utilizando as amostras brutas de água e a exposição aos sedimentos pela interface \ud sedimento-água. Os resultados indicaram, em geral, ausência de toxicidade, tanto para sedimentos quanto para águas, com \ud efeitos tóxicos agudos registrados apenas episodicamente (toxicidade marginal). Tais resultados são coerentes com as baixas \ud concentrações de metais em águas e sedimentos indicadas na literatura, porém diferem do monitoramento feito pela agência \ud ambiental estadual, que tem registrado toxicidade crônica. Essa toxicidade aguda eventual indica, ainda, que embora a qualidade do Rio Ribeira de Iguape esteja sendo recuperada, as condições ainda não estão totalmente controladas.The Ribeira de Iguape River basin received intense mining activities for lead exploiting and, as a result, the river received the \ud discharges of estimated amounts of 5.5 tons/month of material rich in As, Ba, Cd, Pb, Cu, Cr and Zn. In this article, the toxic-ity of waters and sediments collected in Ribeira de Iguape River was assessed aiming to estimate environmental quality. Three \ud sampling campaigns were conducted, from 2009 to 2010. Toxicity tests with the cladoceran Daphnia similiswere done for water \ud samples and for sediments, in this case using sediment-water interface exposure. Results showed in general absence of toxicity \ud for sediments and waters, and only eventually were acute effects registered (marginal toxicity). Results are consistent with the \ud conditions indicated by the literature, of low concentrations of metals in waters and sediments; however they differ from the \ud monitoring made by the state environmental agency, which registered chronic toxicity. The occurrence of eventual acute toxicity \ud indicates that although Ribeira de Iguape River quality is being restored, conditions still are not totally under control.FAPESPFundação de Amparo a Pesquisa do Esta-do de São Paulo (FAPESP) - Processos n. 2008/54607-5 e n. 2009/52762-

Citrus wastewater as a source of value‐added products: Quali‐quantitative analysis and in vitro screening on breast cancer cell lines

Citrus wastewater from industries is a source of bioactive compounds whose recovery could be a useful approach to convert processing waste into potential resources to be exploited in food, pharmaceutical, and chemical companies. Citrus wastewater, obtained from the industrial processing of Citrus sinensis, was freezedried and qualitative/quantitative evaluated using HPLC/MS Q‐TOF analysis. Antiproliferative activity was investigated on MDA‐MB‐231 (triple‐negative breast cancer cell line), MCF‐7 (breast cancer cell line), and its multidrug‐resistant variant MCF‐7R. Fraction 8 emerged for its cytotoxicity toward MCF‐7R cells. Its main component, the polymethoxylated flavone nobiletin (80%), is likely involved in increasing the number of G1‐phase MCF‐7R cells without inducing cell death. Notably, fraction 8 sensitizes MCF7‐R cells to the antiproliferative effects of doxorubicin, thus contributing to overcoming MCF7‐R multidrug resistance. Our studies highlighted the possibility of applying a sustainable strategy for citrus wastewater recycling to recover functional compounds as useful adjuvants for the prevention and treatment of malignancies

A ANÁLISE EPIDEMIOLOGICA DA DOENÇA HEPÁTICA ALCOÓLICA NO BRASIL ENTRE OS ANOS DE 2017 E 2022

Among the health problems resulting from the chronic use of alcohol, Alcoholic Liver Disease (ALD) appears as a consequence of the biochemical attacks caused by ethanol. This condition manifests itself through a spectrum of liver sequelae, which include steatosis, progressive fibrosis, alcoholic hepatitis and cirrhosis. This study aims to describe the prevalence of hospitalizations for alcoholic liver disease in Brazil, from 2018 to 2022. This is a descriptive, ecological and quantitative study that addresses hospital admissions for alcoholic liver disease from 2018 to 2022, based on secondary data from the Information Technology Department of the Unified Health System, following the variables: hospitalizations, deaths, sex, age group, average length of stay and hospital costs. 75,932 hospitalizations for ALD were recorded in Brazil, with a higher prevalence in the Southeast (43.07%). In every year, the number of hospitalizations among men is significantly higher than among women, with an average of 10,579 cases. The age group from 50 to 59 years old presented prevalence, corresponding to 31.31%. The Northeast had higher average length of stay and death, with a total of 9.3 days and 23.26%, respectively. It is crucial to implement strategies that improve early screening of patients with ALD, preventing disease progression and reducing morbidity and mortality.  Dentre os problemas de saúde decorrentes do uso crônico do álcool, a Doença Hepática Alcoólica (DHA) surge como uma consequência das agressões bioquímicas causadas pelo etanol. Essa condição se manifesta por meio de um espectro de sequelas no fígado, que incluem esteatose, fibrose progressiva, hepatite alcoólica e cirrose. Este estudo tem como objetivo descrever a prevalência de internações por doença hepática alcoólica no Brasil, no período de 2018 a 2022. Trata-se de um estudo descritivo, ecológico e quantitativo que aborda internações hospitalares por doença hepática alcoólica no intervalo de 2018 a 2022, a partir de dados secundários do Departamento de Informática do Sistema Único de Saúde, seguindo as variáveis: internações, óbitos, sexo, faixa etária, média de permanência e custos hospitalares. Foram registradas 75.932 internações por DHA no Brasil, com maior prevalência no Sudeste (43,07%). Em todos os anos, o número de internações entre homens é significativamente maior do que entre mulheres, com média de 10.579 casos. A faixa etária de 50 a 59 anos apresentou prevalência, correspondendo a 31,31%. O Nordeste apresentou médias de permanência e óbito mais elevadas, com total de 9,3 dias e 23,26%, respectivamente. É crucial implementar estratégias que aprimorem o rastreamento precoce de pacientes com DHA, prevenindo a progressão da doença e reduzindo a morbimortalidade

International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways.

Primary biliary cirrhosis (PBC) is a classical autoimmune liver disease for which effective immunomodulatory therapy is lacking. Here we perform meta-analyses of discovery data sets from genome-wide association studies of European subjects (n=2,764 cases and 10,475 controls) followed by validation genotyping in an independent cohort (n=3,716 cases and 4,261 controls). We discover and validate six previously unknown risk loci for PBC (Pcombined<5 × 10(-8)) and used pathway analysis to identify JAK-STAT/IL12/IL27 signalling and cytokine-cytokine pathways, for which relevant therapies exist

Azimuthal anisotropy of charged jet production in root s(NN)=2.76 TeV Pb-Pb collisions

We present measurements of the azimuthal dependence of charged jet production in central and semi-central root s(NN) = 2.76 TeV Pb-Pb collisions with respect to the second harmonic event plane, quantified as nu(ch)(2) (jet). Jet finding is performed employing the anti-k(T) algorithm with a resolution parameter R = 0.2 using charged tracks from the ALICE tracking system. The contribution of the azimuthal anisotropy of the underlying event is taken into account event-by-event. The remaining (statistical) region-to-region fluctuations are removed on an ensemble basis by unfolding the jet spectra for different event plane orientations independently. Significant non-zero nu(ch)(2) (jet) is observed in semi-central collisions (30-50% centrality) for 20 <p(T)(ch) (jet) <90 GeV/c. The azimuthal dependence of the charged jet production is similar to the dependence observed for jets comprising both charged and neutral fragments, and compatible with measurements of the nu(2) of single charged particles at high p(T). Good agreement between the data and predictions from JEWEL, an event generator simulating parton shower evolution in the presence of a dense QCD medium, is found in semi-central collisions. (C) 2015 CERN for the benefit of the ALICE Collaboration. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).Peer reviewe

Forward-central two-particle correlations in p-Pb collisions at root s(NN)=5.02 TeV

Two-particle angular correlations between trigger particles in the forward pseudorapidity range (2.5 2GeV/c. (C) 2015 CERN for the benefit of the ALICE Collaboration. Published by Elsevier B. V.Peer reviewe