Use of teriparatide in treatment of severe osteoporosis in geriatric practice: a clinical case review

Elderly and senile people are characterized by a high prevalence of osteoporosis, which, in turn, increases the risk of fractures, including the repeated ones. Fractures in osteoporosis are an extremely unfavorable complication of the disease, leading to catastrophic consequences in old age. The prevalence of osteoporotic fractures progressively increases with age. At present, the cumulative frequency of hip fractures in women over 80 is about 30%. The proportion of vertebral fractures in women older than 80 years is up to 40% of all vertebral osteoporotic fractures. Despite the tremendous successes achieved in the diagnosis and treatment of osteoporosis, the disease itself and related fractures remain a serious medical, economic and social problem. Prevention of recurrent fractures in geriatric patients is a system of preventive, rehabilitative and therapeutic measures aimed at reducing the risk of falls, choosing an effective therapy, and reducing the risk of recurring fractures. A serious problem in the treatment of osteoporosis in older people is the inefficiency of the antiresorptive therapy due to an age-related decrease in bone formation. There are frequent cases of a continuing decrease in bone density, the occurrence of repeated fractures during ongoing therapy of osteoporosis. Often the therapy of choice in this case is bone-anabolic therapy with teriparatide, which allows one to achieve good results in the accumulation of bone mineral density. In this article, we will present the clinical case of an elderly patient with severe osteoporosis, in which teriparatide became the drug of choice

EPMA-World Congress 2015: Bonn, Germany. 3-5 September 2015

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The use of technological aids in the processing of bacterially infected sugar beet

In the technology of beet sugar, technological aids play a special role, but the effectiveness of their complex application in the processing of bacterially infected sugar beets requires study. A three-factor laboratory experiment was carried out on the basis of the D-optimal Box-Behnken plan of the second order for three levels of variation of the studied factors the enzyme preparation Dextrasept 2, the antimicrobial agent Betacept and the defoamer Voltes FSS 93. The quality of 15 studied indicators of the state of intermediate products of the processes of obtaining and purification of diffusion juice, syrup was determined according to the generally accepted methods. The obtained regression equations adequately reflected the combined effect of these drugs on the state indicators. The highest variability (24.2-39.0%) was observed for the turbidity of juices and syrup, and the deposition rate; тhe chromaticity, the content of high-molecular compounds, lactic acid, and the height of the foam column were characterized by an average variation (12.7-17.8%). The sucrose content and the overall effect of purification of diffusion juice changed insignificantly (0.4-3.0%). Сontribution of the enzyme preparation to the variation of 6 indicators was more than 45%, 7 – 3942% and 2 – less than 10%. Under the influence of the antimicrobial agent, 6 indicators changed by more than 45%, 5 – 33-43% and 4 – less than 30%