Velocity of Ultrasonic Waves in Solutions of Electrolytes

List of the genes involved in CVDs according to DisGeNET database. For each gene all the related diseases and the putative EV-MiRNAs targeting it are indicated both as list and as number of occurrences. (PDF 1206 kb

Engineered nanomaterials exposure in the production of graphene

<p>The objective of this study was to obtain the multi-metric occupational exposure assessment to graphene family nanomaterials (GFNs) particles of workers engaged in the large-scale production of graphene. The study design consisted of the combination of (i) direct-reading instruments, used to evaluate the total particle number concentrations relative to the background concentration (time series with spatial approach) and the mean size-dependent characteristics of particles (mean diameter and surface-area concentration) and (ii) filter-based air sampling for the determination of size-resolved particle mass concentrations. The data obtained from direct reading measurement were then used to estimate the 8-h time weighted average (8-h TWA) exposure to GFNs particles for workers involved in different working tasks. Workers were generally exposed to 8-h TWA GFNs particle levels lower than the proposed reference value (40,000 particle/cm³). Furthermore, despite high short-term exposure conditions were present during specific operations of the production process, the possibility of significant exposure peaks is not likely to be expected. The estimated 8-h TWA concentration showed differences between the unexposed (<100 particle/cm³; <0.05 µg/m³) and exposed subjects (mean concentration ranging from 909 to 6438 particle/cm³ and from 0.38 to 3.86 µg/m³). The research outcomes can be of particular interest because the exposure of workers in real working conditions was assessed with a multi-metric approach; in this regard, the study suggests that workers who are directly involved in some specific working task (material sampling for quality control) have higher potential for occupational exposure than operators who are in charge of routine production work.</p> <p>© 2016 American Association for Aerosol Research</p

Subgroup selection process for Phase 2 participants of the HEBE project.

Subgroup selection process for Phase 2 participants of the HEBE project.</p

Sample collection and processing workflow for participants enrolled in the personalized medical protocol.

Sample collection and processing workflow for participants enrolled in the personalized medical protocol.</p

Additional file 1: Table S1. of Mitochondrial oxidative DNA damage and exposure to particulate air pollution in mother-newborn pairs

Mitochondrial and nuclear primer sequence information based upon Assembly GRCh37/hg19 of the UCSC genome browser for mtDNA content measurement. Table S2. Estimated change of mitochondrial 8-OHdG in maternal blood associated with PM10 and PM2.5 exposure during pregnancy while excluding women who continued smoking during pregnancy (n = 193). Table S3. Estimated change of mitochondrial 8-OHdG in cord blood associated with PM10 and PM2.5 exposure during pregnancy while excluding women who continued smoking during pregnancy (n = 246). Table S4. PM exposure, 8-OHdG levels and pregnancy outcomes. (DOCX 24 kb

Conceptual framework for the HEBE research.

The concepts established in Line of Research (LR) 1 (“proof of concept”) serve as the foundation for investigating nine additional LRs. These LRs focus on distinct aspects of inflamm-aging and explore the impact of physical exercise on various sub-cohorts. The planned lines of research are as follows: LR2: Obesity and Comorbidity Development; LR3: Cancer and Inflamm-Aging; LR4: Endocrine Factors in Fragility; LR5: Cardiovascular Disease in Inflamm-Aging; LR6: Inflamm-Aging and Human Fertility; LR7: Psychological Stress and Inflamm-Aging; LR8: Respiratory Diseases and Inflamm-Aging; LR9: Neuroinflammation, Aging, and Frailty; LR10: Autoimmune Diseases and Inflamm-Aging. Each line of research extends from the foundational LR1, collectively contributing to a comprehensive understanding of inflamm-aging and its diverse implications.</p

Characteristics of the study participants and exposure levels (n = 90).

<p>Characteristics of the study participants and exposure levels (n = 90).</p

Titanium and Zirconium Levels Are Associated with Changes in MicroRNAs Expression: Results from a Human Cross-Sectional Study on Obese Population

<div><p>Objectives</p><p>In this study on 90 individuals we aimed at evaluating the microRNAs (miRNAs) expression profile associated with personal levels of Titanium (Ti) and Zirconium (Zr) traced in hair samples. Ti and Zr materials are broadly used for dental implants but the biological reactions triggered by a long term presence of these materials in the oral cavity still need to be assessed. MiRNAs are mechanisms that need to be investigated as they play a fundamental role in the control of gene expression following external stimuli and contribute to a wide range of pathophysiological processes.</p><p>Methods</p><p>Using the TaqMan^® Low-Density Array, we assessed the expression levels of 377 human miRNAs in peripheral blood of 90 subjects. Hair samples were analyzed for Ti and Zr content using Inductively Coupled Plasma-Mass Spectrometry. We performed multivariable regression analysis to investigate the effects of Ti and Zr exposure on miRNA expression levels. We used the Ingenuity Pathway Analysis (IPA) software to explore the functional role of the investigated miRNAs and the related target genes.</p><p>Results</p><p>Seven miRNAs (miR-99b, miR-142-5p, miR-152, miR-193a-5p, miR-323-3p, miR-335, miR-494) resulted specifically associated with Zr levels. The functional target analysis showed that miRNAs are involved in mechanisms such as inflammation, skeletal and connective tissue disorders.</p><p>Conclusions</p><p>Our data suggest that Zr is more bioactive than Ti and show that miRNAs are relevant molecular mechanisms sensitive to Zr exposure.</p></div

Disease and biological function associated with target genes selected with IPA for 7 miRNAs.

<p>Disease and biological function associated with target genes selected with IPA for 7 miRNAs.</p

Cellular location of targets shared by miR-152, miR-335 and miR-494.

<p>Cellular location of targets shared by miR-152, miR-335 and miR-494.</p